Difference between revisions of "Urinary bladder metastasis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Clear cell renal cell carcinoma metastasis to bladder -- intermed mag.jpg | |||
| Width = | |||
| Caption = Clear cell renal cell carcinoma metastasis to urinary bladder. [[H&E stain]]. | |||
| Synonyms = metastasis to urinary bladder | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[urothelial carcinoma]] with unusual features, [[primary adenocarcinoma of the urinary bladder]], direct extension of non-bladder primary tumour in bladder (e.g. [[prostate cancer|prostate]], rectum, [[urachal carcinoma]]) | |||
| Stains = | |||
| IHC = [[GATA3]] -ve/+ve (commonly +ve in breast), beta-catenin +ve/-ve (nuclear staining - suggests colorectal primary), prostate markers (e.g. PSA, PSAP, NKX3.1) +ve/-ve (+ve suggests prostate primary), PAX8 +ve/-ve (+ve suggests gyne tract or RCC) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[urinary bladder]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-history of cancer | |||
| Signs = | |||
| Symptoms = hematuria (typical) | |||
| Prevalence = rare as primary presentation (case reports) | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = bladder tumour | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = primary bladder cancer | |||
| Tx = dependent on primary site | |||
}} | |||
'''Urinary bladder metastasis''', also '''metastasis to the bladder''', is [[cancer]] that has spread to the [[urinary bladder]] from another primary site and is discontinuous with the primary tumour. | '''Urinary bladder metastasis''', also '''metastasis to the bladder''', is [[cancer]] that has spread to the [[urinary bladder]] from another primary site and is discontinuous with the primary tumour. | ||
| Line 4: | Line 36: | ||
*Rare - mostly case reports. | *Rare - mostly case reports. | ||
**[[Renal cell carcinoma]] ~ series of 11 cases.<ref name=pmid25140895>{{Cite journal | last1 = Zhang | first1 = M. | last2 = Wah | first2 = C. | last3 = Epstein | first3 = JI. | title = Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases. | journal = Am J Surg Pathol | volume = 38 | issue = 11 | pages = 1516-21 | month = Nov | year = 2014 | doi = 10.1097/PAS.0000000000000257 | PMID = 25140895 }}</ref> | **[[Renal cell carcinoma]] ~ series of 11 cases.<ref name=pmid25140895>{{Cite journal | last1 = Zhang | first1 = M. | last2 = Wah | first2 = C. | last3 = Epstein | first3 = JI. | title = Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases. | journal = Am J Surg Pathol | volume = 38 | issue = 11 | pages = 1516-21 | month = Nov | year = 2014 | doi = 10.1097/PAS.0000000000000257 | PMID = 25140895 }}</ref> | ||
**Breast primary - small series<ref name=pmid26437333>{{Cite journal | last1 = Avargues | first1 = A. | last2 = Luján | first2 = S. | last3 = Palomar | first3 = L. | last4 = Rogel | first4 = R. | last5 = Broseta | first5 = E. | last6 = Boronat | first6 = F. | title = [Metastatic urinary bladder involvement in breast cancer]. | journal = Arch Esp Urol | volume = 68 | issue = 8 | pages = 676-8 | month = Oct | year = 2015 | doi = | PMID = 26437333 }}</ref> and case reports.<ref name=pmid27047651>{{Cite journal | last1 = Al Ibraheemi | first1 = AA. | title = Case report of metastatic invasive breast lobular carcinoma to the urinary bladder. | journal = Int J Hematol Oncol Stem Cell Res | volume = 10 | issue = 1 | pages = 51-5 | month = Jan | year = 2016 | doi = | PMID = 27047651 }}</ref><ref name=pmid24088591>{{Cite journal | last1 = Wong | first1 = MH. | last2 = Yiu | first2 = MK. | last3 = Ho | first3 = KL. | title = Metastatic carcinoma of breast in the urinary bladder. | journal = Hong Kong Med J | volume = 19 | issue = 5 | pages = 455-7 | month = Oct | year = 2013 | doi = | PMID = 24088591 }}</ref> | |||
A 2007 review of the literature found:<ref name=pmid17324324>{{Cite journal | last1 = Velcheti | first1 = V. | last2 = Govindan | first2 = R. | title = Metastatic cancer involving bladder: a review. | journal = Can J Urol | volume = 14 | issue = 1 | pages = 3443-8 | month = Feb | year = 2007 | doi = | PMID = 17324324 }}</ref> | A 2007 review of the literature found:<ref name=pmid17324324>{{Cite journal | last1 = Velcheti | first1 = V. | last2 = Govindan | first2 = R. | title = Metastatic cancer involving bladder: a review. | journal = Can J Urol | volume = 14 | issue = 1 | pages = 3443-8 | month = Feb | year = 2007 | doi = | PMID = 17324324 }}</ref> | ||
*264 reported cases from 1953 to June 2005. | *264 reported cases from 1953 to June 2005 - most from GU tract and the colorectum. | ||
**Distant site includes [[breast cancer|breast]], stomach and melanoma. | |||
==Microscopic== | ==Microscopic== | ||
Latest revision as of 03:59, 17 January 2017
| Urinary bladder metastasis | |
|---|---|
| Diagnosis in short | |
 Clear cell renal cell carcinoma metastasis to urinary bladder. H&E stain. | |
|
| |
| Synonyms | metastasis to urinary bladder |
| LM DDx | urothelial carcinoma with unusual features, primary adenocarcinoma of the urinary bladder, direct extension of non-bladder primary tumour in bladder (e.g. prostate, rectum, urachal carcinoma) |
| IHC | GATA3 -ve/+ve (commonly +ve in breast), beta-catenin +ve/-ve (nuclear staining - suggests colorectal primary), prostate markers (e.g. PSA, PSAP, NKX3.1) +ve/-ve (+ve suggests prostate primary), PAX8 +ve/-ve (+ve suggests gyne tract or RCC) |
| Site | urinary bladder |
|
| |
| Clinical history | +/-history of cancer |
| Symptoms | hematuria (typical) |
| Prevalence | rare as primary presentation (case reports) |
| Endoscopy | bladder tumour |
| Prognosis | poor |
| Clin. DDx | primary bladder cancer |
| Treatment | dependent on primary site |
Urinary bladder metastasis, also metastasis to the bladder, is cancer that has spread to the urinary bladder from another primary site and is discontinuous with the primary tumour.
General
- Rare - mostly case reports.
- Renal cell carcinoma ~ series of 11 cases.[1]
- Breast primary - small series[2] and case reports.[3][4]
A 2007 review of the literature found:[5]
- 264 reported cases from 1953 to June 2005 - most from GU tract and the colorectum.
- Distant site includes breast, stomach and melanoma.
Microscopic
Features:
- Dependent on the primary site.
DDx:
- Urothelial carcinoma with unusual features.
- Primary adenocarcinoma of the urinary bladder.
- Urachal carcinoma.
- Direct extension of primary tumour from other primary site, e.g. prostate, rectum.
Images
CCRCC in bladder - very low mag. (WC)
CCRCC in bladder - low mag. (WC)
CCRCC in bladder - intermed. mag. (WC)
CCRCC in bladder - high mag. (WC)
See also
References
- ↑ Zhang, M.; Wah, C.; Epstein, JI. (Nov 2014). "Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases.". Am J Surg Pathol 38 (11): 1516-21. doi:10.1097/PAS.0000000000000257. PMID 25140895.
- ↑ Avargues, A.; Luján, S.; Palomar, L.; Rogel, R.; Broseta, E.; Boronat, F. (Oct 2015). "[Metastatic urinary bladder involvement in breast cancer].". Arch Esp Urol 68 (8): 676-8. PMID 26437333.
- ↑ Al Ibraheemi, AA. (Jan 2016). "Case report of metastatic invasive breast lobular carcinoma to the urinary bladder.". Int J Hematol Oncol Stem Cell Res 10 (1): 51-5. PMID 27047651.
- ↑ Wong, MH.; Yiu, MK.; Ho, KL. (Oct 2013). "Metastatic carcinoma of breast in the urinary bladder.". Hong Kong Med J 19 (5): 455-7. PMID 24088591.
- ↑ Velcheti, V.; Govindan, R. (Feb 2007). "Metastatic cancer involving bladder: a review.". Can J Urol 14 (1): 3443-8. PMID 17324324.