Small vessel leukocytoclastic vasculitis: Difference between revisions
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| Caption = Leukocytoclastic vasculitis. [[H&E stain]]. | | Caption = Leukocytoclastic vasculitis. [[H&E stain]]. | ||
| Synonyms = leukocytoclastic vasculitis | | Synonyms = leukocytoclastic vasculitis, hypersensitivity vasculitis | ||
| Micro = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition) | | Micro = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition) | ||
| Subtypes = | | Subtypes = | ||
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| Tx = remove underlying cause; colchicine and/or dapsone; immunosuppression | | Tx = remove underlying cause; colchicine and/or dapsone; immunosuppression | ||
}} | }} | ||
'''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]]. | '''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV''') and '''hypersensitivity vasculitis''',<ref name=pmid26176572>{{Cite journal | last1 = Einhorn | first1 = J. | last2 = Levis | first2 = JT. | title = Dermatologic Diagnosis: Leukocytoclastic Vasculitis. | journal = Perm J | volume = 19 | issue = 3 | pages = 77-8 | month = | year = 2015 | doi = 10.7812/TPP/15-001 | PMID = 26176572 }}</ref> is an inflammatory process of the small [[blood vessel]]. | ||
==General== | ==General== | ||
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*#Neutrophils. | *#Neutrophils. | ||
*#*Fragmentation of [[neutrophil]]s (leukocytoclasia). | *#*Fragmentation of [[neutrophil]]s (leukocytoclasia). | ||
*#Vessel damage: fibrin deposition (bright pink acellular stuff). | *#Vessel damage: fibrin deposition (bright pink acellular stuff) or "nuclear dust" (punctate hyperchromatic material). | ||
DDx: | DDx: | ||
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==Stains== | ==Stains== | ||
*[[PAS stain|PAS]] - look for fungus. | *[[PAS stain|PAS]] - look for fungus. | ||
==Sign out== | |||
<pre> | |||
Skin, Left Outer Thigh, Punch Biopsy: | |||
- Hypersensitivity vasculitis (leukocytoclastic vasculitis). | |||
</pre> | |||
===Alternate=== | |||
<pre> | |||
Skin, Right Leg, Punch Biopsy: | |||
- Leukocytoclastic vasculitis. | |||
</pre> | |||
===Micro=== | |||
The sections show red blood cells extravasation and nuclear dust. Scattered neutrophils are within the wall of small blood vessels. | |||
==See also== | ==See also== | ||