Difference between revisions of "Traumatic ulcerative granuloma with stromal eosinophilia"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Traumatic ulcerative granuloma with stromal eosinophils - alt -- extremely low mag.jpg | |||
| Width = | |||
| Caption = TUGSE. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = stromal [[eosinophil]]s and lymphocytes, ulceration. | |||
| Subtypes = | |||
| LMDDx = [[diffuse large B-cell lymphoma]], [[lobular capillary hemangioma]] (pyogenic granuloma), [[granulation tissue]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[head and neck pathology|head and neck]] - usually tongue | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Traumatic ulcerative granuloma with stromal eosinophilia''', abbreviated '''TUGSE''', is a benign lesion of the oral mucosa.<ref name=pmid16938660>{{Cite journal | last1 = Hirshberg | first1 = A. | last2 = Amariglio | first2 = N. | last3 = Akrish | first3 = S. | last4 = Yahalom | first4 = R. | last5 = Rosenbaum | first5 = H. | last6 = Okon | first6 = E. | last7 = Kaplan | first7 = I. | title = Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa. | journal = Am J Clin Pathol | volume = 126 | issue = 4 | pages = 522-9 | month = Oct | year = 2006 | doi = 10.1309/AFHA406GBT0N2Y64 | PMID = 16938660 }}</ref> | '''Traumatic ulcerative granuloma with stromal eosinophilia''', abbreviated '''TUGSE''', is a benign lesion of the oral mucosa.<ref name=pmid16938660>{{Cite journal | last1 = Hirshberg | first1 = A. | last2 = Amariglio | first2 = N. | last3 = Akrish | first3 = S. | last4 = Yahalom | first4 = R. | last5 = Rosenbaum | first5 = H. | last6 = Okon | first6 = E. | last7 = Kaplan | first7 = I. | title = Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa. | journal = Am J Clin Pathol | volume = 126 | issue = 4 | pages = 522-9 | month = Oct | year = 2006 | doi = 10.1309/AFHA406GBT0N2Y64 | PMID = 16938660 }}</ref> | ||
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*Benign. | *Benign. | ||
*Obscure lesion that is not widely known.<ref name=pmid26538890>{{Cite journal | last1 = Sarangarajan | first1 = R. | last2 = Vaishnavi Vedam | first2 = VK. | last3 = Sivadas | first3 = G. | last4 = Sarangarajan | first4 = A. | last5 = Meera | first5 = S. | title = Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited. | journal = J Pharm Bioallied Sci | volume = 7 | issue = Suppl 2 | pages = S420-3 | month = Aug | year = 2015 | doi = 10.4103/0975-7406.163474 | PMID = 26538890 }}</ref> | *Obscure lesion that is not widely known.<ref name=pmid26538890>{{Cite journal | last1 = Sarangarajan | first1 = R. | last2 = Vaishnavi Vedam | first2 = VK. | last3 = Sivadas | first3 = G. | last4 = Sarangarajan | first4 = A. | last5 = Meera | first5 = S. | title = Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited. | journal = J Pharm Bioallied Sci | volume = 7 | issue = Suppl 2 | pages = S420-3 | month = Aug | year = 2015 | doi = 10.4103/0975-7406.163474 | PMID = 26538890 }}</ref> | ||
==Gross== | |||
*Usually tongue ~ 2/3 of cases.<ref name=pmid24269143>{{Cite journal | last1 = Shen | first1 = WR. | last2 = Chang | first2 = JY. | last3 = Wu | first3 = YC. | last4 = Cheng | first4 = SJ. | last5 = Chen | first5 = HM. | last6 = Wang | first6 = YP. | title = Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases. | journal = J Formos Med Assoc | volume = 114 | issue = 9 | pages = 881-5 | month = Sep | year = 2015 | doi = 10.1016/j.jfma.2013.09.012 | PMID = 24269143 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid26538890/> | Features:<ref name=pmid26538890/> | ||
*Stromal eosinophils and lymphocytes. | *Stromal eosinophils and lymphocytes. | ||
* | *Ulceration. | ||
DDx: | DDx: | ||
*[[Diffuse large B-cell lymphoma]]. | *[[Diffuse large B-cell lymphoma]]. | ||
*[[Lobular capillary hemangioma]]. | *[[Lobular capillary hemangioma]]. | ||
*[[Granulation tissue]]. | |||
===Images=== | |||
<gallery> | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils -- extremely low mag.jpg |TUGSE - extremely low mag. (WC) | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils -- very low mag.jpg |TUGSE - very low mag. (WC) | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils -- low mag.jpg |TUGSE - low mag. (WC) | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils -- intermed mag.jpg |TUGSE - intermed. mag. (WC) | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils - alt -- intermed mag.jpg |TUGSE - intermed. mag. (WC) | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils -- high mag.jpg |TUGSE - high mag. (WC) | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils - alt -- high mag.jpg |TUGSE - high mag. (WC) | |||
Image: Traumatic ulcerative granuloma with stromal eosinophils -- very high mag.jpg |TUGSE - very high mag. (WC) | |||
</gallery> | |||
==Sign out== | |||
<pre> | |||
Lesion, Right Tongue, Excisional Biopsy: | |||
- Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE), see comment. | |||
- NEGATIVE for malignancy. | |||
Comment: | |||
TUGSE is an uncommon benign lesion of the oral mucosa. | |||
</pre> | |||
==See also== | ==See also== | ||
Latest revision as of 04:40, 5 January 2017
| Traumatic ulcerative granuloma with stromal eosinophilia | |
|---|---|
| Diagnosis in short | |
 TUGSE. H&E stain. (WC/Nephron) | |
|
| |
| LM | stromal eosinophils and lymphocytes, ulceration. |
| LM DDx | diffuse large B-cell lymphoma, lobular capillary hemangioma (pyogenic granuloma), granulation tissue |
| Site | head and neck - usually tongue |
|
| |
| Prevalence | uncommon |
| Prognosis | benign |
Traumatic ulcerative granuloma with stromal eosinophilia, abbreviated TUGSE, is a benign lesion of the oral mucosa.[1]
It is also known as traumatic ulcerative granuloma with stromal eosinphils, eosinophilic ulcer of tongue and traumatic eosinophilic granuloma.
General
- Benign.
- Obscure lesion that is not widely known.[2]
Gross
- Usually tongue ~ 2/3 of cases.[3]
Microscopic
Features:[2]
- Stromal eosinophils and lymphocytes.
- Ulceration.
DDx:
Images
TUGSE - extremely low mag. (WC)
TUGSE - very low mag. (WC)
TUGSE - low mag. (WC)
TUGSE - intermed. mag. (WC)
TUGSE - intermed. mag. (WC)
TUGSE - high mag. (WC)
TUGSE - high mag. (WC)
TUGSE - very high mag. (WC)
Sign out
Lesion, Right Tongue, Excisional Biopsy:
- Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE), see comment.
- NEGATIVE for malignancy.
Comment:
TUGSE is an uncommon benign lesion of the oral mucosa.
See also
References
- ↑ Hirshberg, A.; Amariglio, N.; Akrish, S.; Yahalom, R.; Rosenbaum, H.; Okon, E.; Kaplan, I. (Oct 2006). "Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa.". Am J Clin Pathol 126 (4): 522-9. doi:10.1309/AFHA406GBT0N2Y64. PMID 16938660.
- ↑ 2.0 2.1 Sarangarajan, R.; Vaishnavi Vedam, VK.; Sivadas, G.; Sarangarajan, A.; Meera, S. (Aug 2015). "Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited.". J Pharm Bioallied Sci 7 (Suppl 2): S420-3. doi:10.4103/0975-7406.163474. PMID 26538890.
- ↑ Shen, WR.; Chang, JY.; Wu, YC.; Cheng, SJ.; Chen, HM.; Wang, YP. (Sep 2015). "Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases.". J Formos Med Assoc 114 (9): 881-5. doi:10.1016/j.jfma.2013.09.012. PMID 24269143.