Tumour deposit: Difference between revisions
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It is also known as '''discoutinuous extramural extension''' and '''peritumoural deposit'''. | It is also known as '''discoutinuous extramural extension''' and '''peritumoural deposit'''. | ||
Conceptually, tumour deposits are like the ''[[in-transit metastases]]'' of [[malignant melanoma]]<ref name=pmid19136930>{{Cite journal | last1 = Puppa | first1 = G. | last2 = Ueno | first2 = H. | last3 = Kayahara | first3 = M. | last4 = Capelli | first4 = P. | last5 = Canzonieri | first5 = V. | last6 = Colombari | first6 = R. | last7 = Maisonneuve | first7 = P. | last8 = Pelosi | first8 = G. | title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. | journal = Mod Pathol | volume = 22 | issue = 3 | pages = 410-5 | month = Mar | year = 2009 | doi = 10.1038/modpathol.2008.198 | PMID = 19136930 }}</ref> and [[dermatopathology]]. | Conceptually, tumour deposits are like the ''[[in-transit metastases]]'' of [[malignant melanoma]]<ref name=pmid19136930>{{Cite journal | last1 = Puppa | first1 = G. | last2 = Ueno | first2 = H. | last3 = Kayahara | first3 = M. | last4 = Capelli | first4 = P. | last5 = Canzonieri | first5 = V. | last6 = Colombari | first6 = R. | last7 = Maisonneuve | first7 = P. | last8 = Pelosi | first8 = G. | title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. | journal = Mod Pathol | volume = 22 | issue = 3 | pages = 410-5 | month = Mar | year = 2009 | doi = 10.1038/modpathol.2008.198 | PMID = 19136930 }}</ref> and [[dermatopathology]]; however, it is important to note that on a practical level the specific (morphologic/clinical) definitions of ''tumour deposit'' and ''in-transit metastasis'' are different. | ||
==General== | ==General== | ||
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==Definition== | ==Definition== | ||
Definition - TNM/AJCC 7th edition:<ref name=pmid21555695/> | Definition - TNM/AJCC 8th edition for colorectal cancer: | ||
"Tumor deposits are defined as discrete tumor nodules within the lymph drainage area of the primary carcinoma without identifiable lymph node tissue or identifiable vascular or neural structure. The shape, contour, and size of the deposit are not considered in these designations." | |||
Definition - TNM/AJCC 7th edition for colorectal cancer:<ref name=pmid21555695/> | |||
*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour. | *Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour. | ||
**No standardized distance (from tumour) criteria are defined.<ref name=pmid24112678>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Hashiguchi | first2 = Y. | last3 = Shimazaki | first3 = H. | last4 = Shinto | first4 = E. | last5 = Kajiwara | first5 = Y. | last6 = Nakanishi | first6 = K. | last7 = Kato | first7 = K. | last8 = Maekawa | first8 = K. | last9 = Nakamura | first9 = T. | title = Peritumoral deposits as an adverse prognostic indicator of colorectal cancer. | journal = Am J Surg | volume = | issue = | pages = | month = Oct | year = 2013 | doi = 10.1016/j.amjsurg.2013.04.009 | PMID = 24112678 }}</ref> | **No standardized distance (from tumour) criteria are defined.<ref name=pmid24112678>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Hashiguchi | first2 = Y. | last3 = Shimazaki | first3 = H. | last4 = Shinto | first4 = E. | last5 = Kajiwara | first5 = Y. | last6 = Nakanishi | first6 = K. | last7 = Kato | first7 = K. | last8 = Maekawa | first8 = K. | last9 = Nakamura | first9 = T. | title = Peritumoral deposits as an adverse prognostic indicator of colorectal cancer. | journal = Am J Surg | volume = | issue = | pages = | month = Oct | year = 2013 | doi = 10.1016/j.amjsurg.2013.04.009 | PMID = 24112678 }}</ref> | ||
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Notes: | Notes: | ||
*The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth | *The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth, seventh editions.<ref name=pmid21555695/> | ||
*Lesions that are ''not'' in the drainage bed of tumour are [[Colorectal_cancer_staging#Metastasis_stage|metastatic disease]], pM1b. | *Lesions that are ''not'' in the drainage bed of the tumour are [[Colorectal_cancer_staging#Metastasis_stage|metastatic disease]], pM1b. | ||
===Ueno criteria=== | ===Ueno criteria=== | ||
Ueno ''et al.'' propose that a tumour deposit is either:<ref name=pmid24112678/> | Ueno ''et al.'' propose that a tumour deposit is either:<ref name=pmid24112678/> | ||