Adenoid cystic carcinoma: Difference between revisions
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| Micro = [[cribriform architecture]] (other patterns: solid, cords, (bilayered) tubules), cystic spaces filled with basophilic material, scant cytoplasm in most cells, nucleus - small, hyaline stroma | | Micro = [[cribriform architecture]] (other patterns: solid, cords, (bilayered) tubules), cystic spaces filled with basophilic material, scant cytoplasm in most cells, nucleus - small, hyaline stroma | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[pleomorphic adenoma]], [[epithelial-myoepithelial carcinoma]] | | LMDDx = [[pleomorphic adenoma]], [[epithelial-myoepithelial carcinoma]], [[intraductal carcinoma of the salivary gland|intraductal carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[salivary gland]], [[breast]], [[lung]], [[skin]], others | | Site = [[salivary gland]], [[breast]], [[lung]], [[skin]], [[trachea]], others | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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*[[Pleomorphic adenoma]], esp. if encapsulated. | *[[Pleomorphic adenoma]], esp. if encapsulated. | ||
*[[Epithelial-myoepithelial carcinoma]] - esp. for AdCC tubular variant. | *[[Epithelial-myoepithelial carcinoma]] - esp. for AdCC tubular variant. | ||
*[[Human papillomavirus-related multiphenotypic sinonasal carcinoma]] (previously known as [[human papillomavirus-related carcinoma with adenoid cystic-like features]]). | |||
*[[Intraductal carcinoma of the salivary gland]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Adenoid cystic carcinoma - low mag.jpg | AdCC - low mag. (WC/Nephron) | Image:Adenoid cystic carcinoma - low mag.jpg | AdCC - low mag. (WC/Nephron) | ||
Image:Adenoid_cystic_carcinoma_-_intermed_mag.jpg | AdCC - intermed. mag. (WC/Nephron) | Image:Adenoid_cystic_carcinoma_-_intermed_mag.jpg | AdCC - intermed. mag. (WC/Nephron) | ||
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Image:Adenoid cystic carcinoma - very high mag.jpg | AdCC - very high mag. (WC/Nephron) | Image:Adenoid cystic carcinoma - very high mag.jpg | AdCC - very high mag. (WC/Nephron) | ||
Image:Adenoid_cystic_carcinoma_-a-_very_high_mag.jpg | AdCC - very high mag. (WC/Nephron) | Image:Adenoid_cystic_carcinoma_-a-_very_high_mag.jpg | AdCC - very high mag. (WC/Nephron) | ||
File:Breast_AdenoidCysticCarcinoma_SolidType_14BR***.jpg | AdCC of breast - solid type (WC/Sarahkayb) | |||
</gallery> | |||
<gallery> | |||
Image: Adenoid cystic carcinoma of the trachea -- low mag.jpg | AdCC [[trachea]] - low mag. | |||
Image: Adenoid cystic carcinoma of the trachea -- intermed mag.jpg | AdCC trachea - intermed. mag. | |||
Image: Adenoid cystic carcinoma of the trachea -- high mag.jpg | AdCC trachea - high mag. | |||
Image: Adenoid cystic carcinoma of the trachea -- very high mag.jpg | AdCC trachea - very high mag. | |||
Image: Adenoid cystic carcinoma of the trachea - alt -- very high mag.jpg | AdCC trachea - very high mag. | |||
</gallery> | </gallery> | ||
===Grading=== | ===Grading=== | ||
Based on solid component: | Based on solid component: | ||
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**Seen in ~50% of cases. | **Seen in ~50% of cases. | ||
**Worse prognosis if present, esp. if fusion assoc. with transcription. | **Worse prognosis if present, esp. if fusion assoc. with transcription. | ||
==Sign out== | |||
===Micro=== | |||
The sections show a tumour with a cribriform architecture. The cystic spaces have basophilic material. The tumour cells are carrot-like and have scant/modest cytoplasm. | |||
==See also== | ==See also== | ||