Follicular dendritic cell sarcoma: Difference between revisions

Jump to navigation Jump to search
← Older edit
Michael (talk | contribs)
49,298 edits
No edit summary
Michael (talk | contribs)
49,298 edits
Teeak
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Follicular dendritic cell sarcoma - alt -- very high mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = [[Micrograph]] showing a follicular dendritic cell sarcoma. The (benign) interspersed lymphocytes are a characteristic finding. [[H&E stain]].
| Synonyms  =
| Synonyms  = follicular dendritic cell tumour, follicular dendritic cell neoplasm
| Micro      = oval or spindle-shaped cellular & nuclear morphology, variable architecture (sheets, fascicles, whorles, storiform pattern), nuclei with small nucleoli and clear or dispersed chromatin, multinucleated cells, interspersed small lymphocytes, +/-necrosis, +/-marked nuclear atypia, +/-abundant mitoses.
| Micro      = oval or spindle-shaped cellular & nuclear morphology, variable architecture (sheets, fascicles, whorles, storiform pattern), nuclei with small nucleoli and clear or dispersed chromatin, multinucleated cells, interspersed small lymphocytes, +/-necrosis, +/-marked nuclear atypia, +/-abundant mitoses.
| Subtypes  =
| Subtypes  =
| LMDDx      = [[histiocytic sarcoma]], [[thymoma]], other [[spindle cell lesions]]
| LMDDx      = [[histiocytic sarcoma]], [[thymoma]], other [[spindle cell lesions]]
| Stains    =
| Stains    =
| IHC        = CD21 +ve, CD35 +ve, Ki-M4p +ve, Ki-FDRC1p +ve, vimentin +ve
| IHC        = CD21 +ve, CD23 +ve, CD35 +ve, Ki-M4p +ve, Ki-FDRC1p +ve, vimentin +ve
| EM        =
| EM        =
| Molecular  =
| Molecular  =
Line 33: Line 33:
'''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour.
'''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour.


It is also known as '''follicular dendritic cell tumour''' (abbreviated '''FDCT''').<ref name=pmid17515347>{{Cite journal  | last1 = Leipsic | first1 = JA. | last2 = McAdams | first2 = HP. | last3 = Sporn | first3 = TA. | title = Follicular dendritic cell sarcoma of the mediastinum. | journal = AJR Am J Roentgenol | volume = 188 | issue = 6 | pages = W554-6 | month = Jun | year = 2007 | doi = 10.2214/AJR.04.1530 | PMID = 17515347 }}</ref>
It is also known as '''follicular dendritic cell tumour''' (abbreviated '''FDCT'''),<ref name=pmid17515347>{{Cite journal  | last1 = Leipsic | first1 = JA. | last2 = McAdams | first2 = HP. | last3 = Sporn | first3 = TA. | title = Follicular dendritic cell sarcoma of the mediastinum. | journal = AJR Am J Roentgenol | volume = 188 | issue = 6 | pages = W554-6 | month = Jun | year = 2007 | doi = 10.2214/AJR.04.1530 | PMID = 17515347 }}</ref> and '''follicular dendritic cell neoplasm'''.<ref name=pmid19391666>{{Cite journal  | last1 = Denning | first1 = KL. | last2 = Olson | first2 = PR. | last3 = Maley | first3 = RH. | last4 = Flati | first4 = VR. | last5 = Myers | first5 = JL. | last6 = Silverman | first6 = JF. | title = Primary pulmonary follicular dendritic cell neoplasm: a case report and review of the literature. | journal = Arch Pathol Lab Med | volume = 133 | issue = 4 | pages = 643-7 | month = Apr | year = 2009 | doi = 10.1043/1543-2165-133.4.643 | PMID = 19391666 }}</ref>
 
Other possible names are: ''dendritic reticulum cell sarcoma'', (???) ''follicular dendritic cell neoplasm''. (???)


==General==
==General==
Line 41: Line 39:
*Behave like a low-grade sarcoma.<ref name=pmid9606805>{{Cite journal  | last1 = Perez-Ordoñez | first1 = B. | last2 = Rosai | first2 = J. | title = Follicular dendritic cell tumor: review of the entity. | journal = Semin Diagn Pathol | volume = 15 | issue = 2 | pages = 144-54 | month = May | year = 1998 | doi =  | PMID = 9606805 }}</ref>
*Behave like a low-grade sarcoma.<ref name=pmid9606805>{{Cite journal  | last1 = Perez-Ordoñez | first1 = B. | last2 = Rosai | first2 = J. | title = Follicular dendritic cell tumor: review of the entity. | journal = Semin Diagn Pathol | volume = 15 | issue = 2 | pages = 144-54 | month = May | year = 1998 | doi =  | PMID = 9606805 }}</ref>
*Reported association with [[Castleman disease]] (hyaline-vascular type).<ref name=pmid9606805/>
*Reported association with [[Castleman disease]] (hyaline-vascular type).<ref name=pmid9606805/>
WHO 2001 classification of dendritic cell neoplasms:<ref name=pmid17636477>{{Cite journal  | last1 = Kairouz | first1 = S. | last2 = Hashash | first2 = J. | last3 = Kabbara | first3 = W. | last4 = McHayleh | first4 = W. | last5 = Tabbara | first5 = IA. | title = Dendritic cell neoplasms: an overview. | journal = Am J Hematol | volume = 82 | issue = 10 | pages = 924-8 | month = Oct | year = 2007 | doi = 10.1002/ajh.20857 | PMID = 17636477 }}</ref>
*[[Langerhans cell histiocytosis]].
*Langerhans cell sarcoma.
*Interdigitating dendritic cell sarcoma/tumour.
*Follicular dendritic cell sarcoma/tumour.
*Dendritic cell sarcoma, not specified otherwise.
==Gross==
Features:
*Often a head and neck lesion.{{fact}}


==Microscopic==
==Microscopic==
Line 58: Line 67:
*[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal  | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue =  | pages = 7 | month =  | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref>
*[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal  | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue =  | pages = 7 | month =  | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref>
*[[Thymoma]].
*[[Thymoma]].
*[[Spindle cell lesions]].
*[[Spindle cell lesions]] such as [[sarcomatoid carcinoma]].
*[[Meningioma]].{{fact}}


===Images===
===Images===
==Related images==
<gallery>
Image: Follicular dendritic cell sarcoma -- very low mag.jpg | FDCS - very low mag. (WC)
Image: Follicular dendritic cell sarcoma -- low mag.jpg | FDCS - low mag. (WC)
Image: Follicular dendritic cell sarcoma - alt -- low mag.jpg | FDCS - low mag. (WC)
Image: Follicular dendritic cell sarcoma -- intermed mag.jpg | FDCS - intermed. mag. (WC)
Image: Follicular dendritic cell sarcoma -- high mag.jpg | FDCS - high mag. (WC)
Image: Follicular dendritic cell sarcoma -- very high mag.jpg | FDCS - very high mag. (WC)
Image: Follicular dendritic cell sarcoma - alt -- very high mag.jpg | FDCS - very high mag. (WC)
</gallery>
====www====
*[http://www.ajronline.org/doi/full/10.2214/AJR.04.1530 FDCS (ajronline.org)].<ref name=pmid17515347/>
*[http://www.ajronline.org/doi/full/10.2214/AJR.04.1530 FDCS (ajronline.org)].<ref name=pmid17515347/>
*[http://www.webpathology.com/image.asp?case=391&n=1 DRCS (webpathology.com)].
*[http://www.npplweb.com/manuscripts/2MXAJX4VWD/0/imgfolder/WJSMRO_2_1_Fig2.jpg FDCS (npplweb.com)].<ref>URL: [http://www.npplweb.com/wjsmro/fulltext/2/1 http://www.npplweb.com/wjsmro/fulltext/2/1]. Accessed on: September 13, 2014.</ref>
*[http://www.npplweb.com/manuscripts/2MXAJX4VWD/0/imgfolder/WJSMRO_2_1_Fig2.jpg FDCS (npplweb.com)].<ref>URL: [http://www.npplweb.com/wjsmro/fulltext/2/1 http://www.npplweb.com/wjsmro/fulltext/2/1]. Accessed on: September 13, 2014.</ref>
*[http://path.upmc.edu/cases/case55/dx.html FDCT - several crappy images (upmc.edu)].
*[http://path.upmc.edu/cases/case55/dx.html FDCT - several crappy images (upmc.edu)].
Line 78: Line 99:
*Muscle-specific actin +ve/-ve.
*Muscle-specific actin +ve/-ve.
*EMA +ve/-ve.
*EMA +ve/-ve.
Additional stains:<ref name=pmid21055030>{{Cite journal  | last1 = Yin | first1 = WH. | last2 = Yu | first2 = GY. | last3 = Ma | first3 = Y. | last4 = Rao | first4 = HL. | last5 = Lin | first5 = SX. | last6 = Shao | first6 = CK. | last7 = Liang | first7 = Q. | last8 = Guo | first8 = N. | last9 = Chen | first9 = GQ. | title = [Follicular dendritic cell sarcoma: a clinicopathologic analysis of ten cases]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 39 | issue = 8 | pages = 522-7 | month = Aug | year = 2010 | doi =  | PMID = 21055030 }}</ref>
*CD23 +ve.
*D2-40 +ve.
Note:
*The interspersed lymphocytes are B cells.<ref name=pmid21835430>{{Cite journal  | last1 = Lorenzi | first1 = L. | last2 = Lonardi | first2 = S. | last3 = Petrilli | first3 = G. | last4 = Tanda | first4 = F. | last5 = Bella | first5 = M. | last6 = Laurino | first6 = L. | last7 = Rossi | first7 = G. | last8 = Facchetti | first8 = F. | title = Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders. | journal = Hum Pathol | volume = 43 | issue = 2 | pages = 209-15 | month = Feb | year = 2012 | doi = 10.1016/j.humpath.2011.02.029 | PMID = 21835430 }}</ref>
===Images===
<gallery>
Image: Follicular dendritic cell sarcoma - CD23 -- high mag.jpg | FDCS - CD23 - high mag. (WC)
Image: Follicular dendritic cell sarcoma - CD23 -- very high mag.jpg | FDCS - CD23 - very high mag. (WC)
Image: Follicular dendritic cell sarcoma - CD21 -- high mag.jpg | FDCS - CD21 - high mag. (WC)
Image: Follicular dendritic cell sarcoma - CD21 -- very high mag.jpg | FDCS - CD21 - very high mag. (WC)
</gallery>


==See also==
==See also==
Retrieved from "https://librepathology.org/wiki/Follicular_dendritic_cell_sarcoma"