Difference between revisions of "DOG1"
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==Positive== | ==Positive== | ||
*[[Gastrointestinal stromal tumour]] ~ 94% of cases.<ref name=pmid19606013 >{{Cite journal | last1 = Miettinen | first1 = M. | last2 = Wang | first2 = ZF. | last3 = Lasota | first3 = J. | title = DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 9 | pages = 1401-8 | month = Sep | year = 2009 | doi = 10.1097/PAS.0b013e3181a90e1a | PMID = 19606013 }}</ref> | *[[Gastrointestinal stromal tumour]] ~ 94% of cases.<ref name=pmid19606013 >{{Cite journal | last1 = Miettinen | first1 = M. | last2 = Wang | first2 = ZF. | last3 = Lasota | first3 = J. | title = DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 9 | pages = 1401-8 | month = Sep | year = 2009 | doi = 10.1097/PAS.0b013e3181a90e1a | PMID = 19606013 }}</ref> | ||
*[[Chromophobe renal cell carcinoma]] | *[[Chromophobe renal cell carcinoma]] ~ 86% of cases.<ref name=pmid26678977>{{Cite journal | last1 = Swalchick | first1 = W. | last2 = Shamekh | first2 = R. | last3 = Bui | first3 = MM. | title = Is DOG1 Immunoreactivity Specific to Gastrointestinal Stromal Tumor? | journal = Cancer Control | volume = 22 | issue = 4 | pages = 498-504 | month = Oct | year = 2015 | doi = | PMID = 26678977 }}</ref> | ||
*[[Renal oncocytoma]]. | *[[Renal oncocytoma]] ~100% of cases.<ref name=pmid26678977/> | ||
===Occasional positive=== | ===Occasional positive=== | ||
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Note: | Note: | ||
*There are different clones for DOG1 and | *There are different commercially available clones for DOG1 (''DOG1.1'' and ''K9''). The [[sensitivity]] and [[specificity]] are not the same.<ref name=pmid20571340>{{Cite journal | last1 = Lopes | first1 = LF. | last2 = West | first2 = RB. | last3 = Bacchi | first3 = LM. | last4 = van de Rijn | first4 = M. | last5 = Bacchi | first5 = CE. | title = DOG1 for the diagnosis of gastrointestinal stromal tumor (GIST): Comparison between 2 different antibodies. | journal = Appl Immunohistochem Mol Morphol | volume = 18 | issue = 4 | pages = 333-7 | month = Jul | year = 2010 | doi = 10.1097/PAI.0b013e3181d27ec8 | PMID = 20571340 }}</ref> | ||
==See also== | ==See also== | ||
*[[Immunohistochemistry]]. | *[[Immunohistochemistry]]. | ||
Latest revision as of 20:48, 26 February 2020
DOG1 is a common immunostain classically used to diagnosis gastrointestinal stromal tumour.
Positive
- Gastrointestinal stromal tumour ~ 94% of cases.[1]
- Chromophobe renal cell carcinoma ~ 86% of cases.[2]
- Renal oncocytoma ~100% of cases.[2]
Occasional positive
- Retroperitoneal leiomyoma.[1]
- Peritoneal leiomyomatosis.[1]
- Synovial sarcoma.[1]
Note:
- There are different commercially available clones for DOG1 (DOG1.1 and K9). The sensitivity and specificity are not the same.[3]
See also
References
- ↑ 1.0 1.1 1.2 1.3 Miettinen, M.; Wang, ZF.; Lasota, J. (Sep 2009). "DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases.". Am J Surg Pathol 33 (9): 1401-8. doi:10.1097/PAS.0b013e3181a90e1a. PMID 19606013.
- ↑ 2.0 2.1 Swalchick, W.; Shamekh, R.; Bui, MM. (Oct 2015). "Is DOG1 Immunoreactivity Specific to Gastrointestinal Stromal Tumor?". Cancer Control 22 (4): 498-504. PMID 26678977.
- ↑ Lopes, LF.; West, RB.; Bacchi, LM.; van de Rijn, M.; Bacchi, CE. (Jul 2010). "DOG1 for the diagnosis of gastrointestinal stromal tumor (GIST): Comparison between 2 different antibodies.". Appl Immunohistochem Mol Morphol 18 (4): 333-7. doi:10.1097/PAI.0b013e3181d27ec8. PMID 20571340.