Difference between revisions of "Branchial cleft cyst"

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#redirect [[Head and neck pathology#Branchial cleft cyst]]
'''Branchial cleft cyst''', also '''branchial cleft remnant''', is a benign congenital lesion of the [[head and neck pathology|head and neck]].
 
==General==
*Benign congenital thingy in the lateral neck.<ref>URL: [http://www.childrenshospital.org/az/Site663/mainpageS663P0.html http://www.childrenshospital.org/az/Site663/mainpageS663P0.html]. Accessed on: 15 March 2011.</ref>
*Most common cystic neck lesion in young adults.<ref name=pmid19593684>{{Cite journal  | last1 = Pietarinen-Runtti | first1 = P. | last2 = Apajalahti | first2 = S. | last3 = Robinson | first3 = S. | last4 = Passador-Santos | first4 = F. | last5 = Leivo | first5 = I. | last6 = Mäkitie | first6 = AA. | title = Cystic neck lesions: clinical, radiological and differential diagnostic considerations. | journal = Acta Otolaryngol | volume = 130 | issue = 2 | pages = 300-4 | month = Feb | year = 2010 | doi = 10.3109/00016480903127450 | PMID = 19593684 }}</ref>
*Treatment: excision.
 
==Gross==
*Lateral neck mass.
 
Image - clinical:
*[http://medical-dictionary.thefreedictionary.com/_/viewer.aspx?path=mosby&name=500051-fx23.jpg Branchial cleft cyst (thefreedictionary.com)].
 
==Microscopic==
Features:
*Cystic space lined by squamous epithelium - usually.
**+/-Inflammation.
*Connective tissue:
**+/-Adipose tissue.
**+/-Cartilage.
**+/-Bone.
**+/-Muscle.
 
DDx:
*Cystic [[squamous cell carcinoma]] - may be deceptively benign appearing.<ref name=pmid19593684>{{Cite journal  | last1 = Pietarinen-Runtti | first1 = P. | last2 = Apajalahti | first2 = S. | last3 = Robinson | first3 = S. | last4 = Passador-Santos | first4 = F. | last5 = Leivo | first5 = I. | last6 = Mäkitie | first6 = AA. | title = Cystic neck lesions: clinical, radiological and differential diagnostic considerations. | journal = Acta Otolaryngol | volume = 130 | issue = 2 | pages = 300-4 | month = Feb | year = 2010 | doi = 10.3109/00016480903127450 | PMID = 19593684 }}</ref>
*[[Papillary thyroid carcinoma]] (PTC) arising in a brachial cleft cyst<ref name=pmid20187788>{{Cite journal  | last1 = Park | first1 = J. | last2 = Kwon | first2 = SY. | last3 = Kim | first3 = NH. | last4 = Baik | first4 = SH. | last5 = Choi | first5 = DS. | title = Papillary thyroid carcinoma arising in a branchial cleft cyst. | journal = Thyroid | volume = 20 | issue = 3 | pages = 347-9 | month = Mar | year = 2010 | doi = 10.1089/thy.2009.0124 | PMID = 20187788 }}</ref> - uncommon, looks like PTC in the thyroid.
*[[Epidermal inclusion cyst]].
 
===Images===
*[http://www.flickr.com/photos/jian-hua_qiao_md/8599213842/in/photostream/ BCC (flickr.com/Qiao)].
*[http://www.flickr.com/photos/jian-hua_qiao_md/8599214250/in/photostream/ BCC (flickr.com/Qiao)].
 
==IHC==
*p16 -ve.
**May be done to exclude a [[HPV-associated head and neck squamous cell carcinoma]].
*Ki-67 low.
 
==Sign out==
<pre>
Right Neck Mass, Fine Needle Aspiration (FNA):
- Benign squamous cells and debris admixed in a background of inflammatory cells.
- Moderately cellular specimen.
 
Comment:
The differential diagnosis includes branchial cleft cyst and epidermal inclusion
cyst. Clinical correlation is required.
</pre>
 
==See also==
*[[Head and neck pathology]].
 
==References==
{{Reflist|2}}
 
[[Category:Head and neck pathology]]
[[Category:Diagnosis]]

Latest revision as of 14:44, 16 October 2015

Branchial cleft cyst, also branchial cleft remnant, is a benign congenital lesion of the head and neck.

General

  • Benign congenital thingy in the lateral neck.[1]
  • Most common cystic neck lesion in young adults.[2]
  • Treatment: excision.

Gross

  • Lateral neck mass.

Image - clinical:

Microscopic

Features:

  • Cystic space lined by squamous epithelium - usually.
    • +/-Inflammation.
  • Connective tissue:
    • +/-Adipose tissue.
    • +/-Cartilage.
    • +/-Bone.
    • +/-Muscle.

DDx:

Images

IHC

Sign out

Right Neck Mass, Fine Needle Aspiration (FNA):
- Benign squamous cells and debris admixed in a background of inflammatory cells. 
- Moderately cellular specimen.

Comment:
The differential diagnosis includes branchial cleft cyst and epidermal inclusion
cyst. Clinical correlation is required.

See also

References

  1. URL: http://www.childrenshospital.org/az/Site663/mainpageS663P0.html. Accessed on: 15 March 2011.
  2. 2.0 2.1 Pietarinen-Runtti, P.; Apajalahti, S.; Robinson, S.; Passador-Santos, F.; Leivo, I.; Mäkitie, AA. (Feb 2010). "Cystic neck lesions: clinical, radiological and differential diagnostic considerations.". Acta Otolaryngol 130 (2): 300-4. doi:10.3109/00016480903127450. PMID 19593684.
  3. Park, J.; Kwon, SY.; Kim, NH.; Baik, SH.; Choi, DS. (Mar 2010). "Papillary thyroid carcinoma arising in a branchial cleft cyst.". Thyroid 20 (3): 347-9. doi:10.1089/thy.2009.0124. PMID 20187788.