Difference between revisions of "Lymphocytic gastritis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Lymphocytic gastritis -- high mag.jpg | |||
| Width = | |||
| Caption = Lymphocytic gastritis. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = intraepithelial lymphocytes (>25 lymphocytes/100 epithelial cells) | |||
| Subtypes = primary (idiopathic), secondary | |||
| LMDDx = [[Helicobacter gastritis]], [[Crohn's disease]], [[lymphoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[stomach]] | |||
| Assdx = [[celiac disease]] (common), [[HIV]] | |||
| Syndromes = | |||
| Clinicalhx = dependent on underlying cause | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = dependent underlying cause | |||
}} | |||
'''Lymphocytic gastritis''', abbreviated '''LG''', is a rare form of [[gastritis]], typically associated with [[celiac disease]] or [[Helicobacter pylori]] infection. | '''Lymphocytic gastritis''', abbreviated '''LG''', is a rare form of [[gastritis]], typically associated with [[celiac disease]] or [[Helicobacter pylori]] infection. | ||
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#[[Celiac disease]] - most common (39 of 82 cases in one series<ref name=pmid9989841>{{Cite journal | last1 = Wu | first1 = TT. | last2 = Hamilton | first2 = SR. | title = Lymphocytic gastritis: association with etiology and topology. | journal = Am J Surg Pathol | volume = 23 | issue = 2 | pages = 153-8 | month = Feb | year = 1999 | doi = | PMID = 9989841 }}</ref>). | #[[Celiac disease]] - most common (39 of 82 cases in one series<ref name=pmid9989841>{{Cite journal | last1 = Wu | first1 = TT. | last2 = Hamilton | first2 = SR. | title = Lymphocytic gastritis: association with etiology and topology. | journal = Am J Surg Pathol | volume = 23 | issue = 2 | pages = 153-8 | month = Feb | year = 1999 | doi = | PMID = 9989841 }}</ref>). | ||
#[[Helicobacter gastritis]] - common (30 of 82 cases in one series<ref name=pmid9989841/>). | #[[Helicobacter gastritis]] - common (30 of 82 cases in one series<ref name=pmid9989841/>). | ||
#Idiopathic. | #Idiopathic. | ||
#HIV/AIDS. | #[[HIV]]/AIDS. | ||
#Crohn's disease. | #[[Crohn's disease]]. | ||
#Lymphoma. | #[[Lymphoma]]. | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref> | Features:<ref name=pmid9659261>{{Cite journal | last1 = Feeley | first1 = KM. | last2 = Heneghan | first2 = MA. | last3 = Stevens | first3 = FM. | last4 = McCarthy | first4 = CF. | title = Lymphocytic gastritis and coeliac disease: evidence of a positive association. | journal = J Clin Pathol | volume = 51 | issue = 3 | pages = 207-10 | month = Mar | year = 1998 | doi = | PMID = 9659261 }}</ref> | ||
*25 lymphocytes / 100 epithelial cells. | *25 lymphocytes / 100 epithelial cells. | ||
DDx: | DDx: | ||
*[[Helicobacter gastritis]] - Helicobacter-like organisms present. | *[[Helicobacter gastritis]] - Helicobacter-like organisms present. | ||
*[[Lymphoma]] - esp. [[MALT lymphoma]]. | |||
===Images=== | |||
<gallery> | |||
Image: Lymphocytic gastritis -- low mag.jpg | LG - low mag. (WC) | |||
Image: Lymphocytic gastritis -- intermed mag.jpg | LG - intermed. mag. (WC) | |||
Image: Lymphocytic gastritis - alt -- intermed mag.jpg | LG - intermed. mag. (WC) | |||
Image: Lymphocytic gastritis -- high mag.jpg | LG - high mag. (WC) | |||
Image: Lymphocytic gastritis - alt -- high mag.jpg | LG - high mag. (WC) | |||
Image: Lymphocytic gastritis - alt 2 -- high mag.jpg | LG - high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*Lymphocytes CD8 predominant; can be used to help exclude MALT lymphoma. | |||
==See also== | ==See also== | ||
*[[Gastritis]]. | *[[Gastritis]]. | ||
*[[Lymphocytic colitis]]. | |||
*[[Celiac disease]]. | |||
==References== | ==References== | ||
Latest revision as of 16:04, 10 July 2016
| Lymphocytic gastritis | |
|---|---|
| Diagnosis in short | |
 Lymphocytic gastritis. H&E stain. (WC/Nephron) | |
|
| |
| LM | intraepithelial lymphocytes (>25 lymphocytes/100 epithelial cells) |
| Subtypes | primary (idiopathic), secondary |
| LM DDx | Helicobacter gastritis, Crohn's disease, lymphoma |
| Site | stomach |
|
| |
| Associated Dx | celiac disease (common), HIV |
| Clinical history | dependent on underlying cause |
| Prevalence | rare |
| Prognosis | benign |
| Treatment | dependent underlying cause |
Lymphocytic gastritis, abbreviated LG, is a rare form of gastritis, typically associated with celiac disease or Helicobacter pylori infection.
General
The DDx is limited:
- Celiac disease - most common (39 of 82 cases in one series[1]).
- Helicobacter gastritis - common (30 of 82 cases in one series[1]).
- Idiopathic.
- HIV/AIDS.
- Crohn's disease.
- Lymphoma.
Microscopic
Features:[2]
- 25 lymphocytes / 100 epithelial cells.
DDx:
- Helicobacter gastritis - Helicobacter-like organisms present.
- Lymphoma - esp. MALT lymphoma.
Images
LG - low mag. (WC)
LG - intermed. mag. (WC)
LG - intermed. mag. (WC)
LG - high mag. (WC)
LG - high mag. (WC)
LG - high mag. (WC)
IHC
- Lymphocytes CD8 predominant; can be used to help exclude MALT lymphoma.
See also
References
- ↑ 1.0 1.1 Wu, TT.; Hamilton, SR. (Feb 1999). "Lymphocytic gastritis: association with etiology and topology.". Am J Surg Pathol 23 (2): 153-8. PMID 9989841.
- ↑ Feeley, KM.; Heneghan, MA.; Stevens, FM.; McCarthy, CF. (Mar 1998). "Lymphocytic gastritis and coeliac disease: evidence of a positive association.". J Clin Pathol 51 (3): 207-10. PMID 9659261.