Germ cell neoplasia in situ: Difference between revisions
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| Caption = GCNIS (left of image). [[H&E stain]]. | | Caption = GCNIS (left of image). [[H&E stain]]. | ||
| Synonyms = | | Synonyms = intratubular germ cell neoplasia (old term) | ||
| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule | | Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule | ||
| Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular | | Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular non-seminoma) | ||
| LMDDx = [[seminoma]], [[embryonal carcinoma]], Sertoli cell-only syndrome | | LMDDx = [[seminoma]], [[embryonal carcinoma]], Sertoli cell-only syndrome, [[mixed germ cell tumour]] | ||
| Stains = | | Stains = | ||
| IHC = OCT4, PLAP +ve, D2-40 +ve | | IHC = OCT4, PLAP +ve, D2-40 +ve | ||
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*[[Seminoma]] - especially intratubular predominant growth pattern. | *[[Seminoma]] - especially intratubular predominant growth pattern. | ||
*[[Embryonal carcinoma]]. | *[[Embryonal carcinoma]]. | ||
*[[Mixed germ cell tumour]]. | |||
===Images=== | ===Images=== | ||