Urothelial carcinoma of the urethra: Difference between revisions

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'''Urothelial carcinoma of the urethra''' is uncommon. It may be primary, i.e. arises in the [[urethra]], or secondary (spreads from the bladder or upper genitourinary tract).
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Urothelial carcinoma in prostate - 2 -- high mag.jpg
| Width      =
| Caption    = Urothelial carcinoma and benign prostatic tissue in keeping with urethral urothelial carcinoma. [[H&E stain]]. (WC/Nephron)
| Synonyms  =
| Micro      =
| Subtypes  =
| LMDDx      = [[prostatic carcinoma]] - especially poorly differentiated and [[urothelial carcinoma-like prostatic carcinoma]]
| Stains    = [[GATA3]] +ve, [[p63]] +ve, CK5/6 +ve, [[PSA]] -ve, [[PSAP]] -ve
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  = [[cystoprostatectomy grossing]], [[TURP grossing]]
| Staging    =
| Site      = [[urethra]] - also see [[prostate]] ([[prostate cancer]])
| Assdx      =
| Syndromes  =
| Clinicalhx = +/-radiation therapy, [[bladder cancer]]
| Signs      = +/-[[hematuria]]
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = benign urethral stricture
| Tx        = [[cystoprostatectomy]]/cystectomy or endoscopic resection
}}
'''Urothelial carcinoma of the urethra''' is an uncommon epithelial [[malignancy]] of the [[urethra]]. It may be primary, i.e. arises in the urethra, or secondary (spreads from the bladder or upper genitourinary tract).


'''Prostatic urothelial carcinoma''' and '''urothelial carcinoma of the prostate gland''' redirect here.  
'''Prostatic urothelial carcinoma''' and '''urothelial carcinoma of the prostate gland''' redirect here.  
''[[Distal urethral cancers of the penis]]'' are dealt with separately.


==General==
==General==
*May arise secondary to radiation for [[prostate cancer]].<ref name=pmid933273>{{Cite journal  | last1 = Novicki | first1 = DE. | last2 = Gehring | first2 = GG. | title = Urethral carcinoma after radiation therapy for mixed prostatic carcinoma. | journal = J Urol | volume = 116 | issue = 1 | pages = 122-3 | month = Jul | year = 1976 | doi =  | PMID = 933273 }}</ref>
*May arise secondary to radiotherapy for [[prostate cancer]].<ref name=pmid933273>{{Cite journal  | last1 = Novicki | first1 = DE. | last2 = Gehring | first2 = GG. | title = Urethral carcinoma after radiation therapy for mixed prostatic carcinoma. | journal = J Urol | volume = 116 | issue = 1 | pages = 122-3 | month = Jul | year = 1976 | doi =  | PMID = 933273 }}</ref><ref name=pmid1433634>{{Cite journal  | last1 = Winters | first1 = JC. | last2 = Fuselier | first2 = HA. | title = Invasive bladder cancer following 125iodine implants. | journal = J Urol | volume = 148 | issue = 6 | pages = 1898-900 | month = Dec | year = 1992 | doi =  | PMID = 1433634 }}</ref>
*Spreads from the [[urinary bladder]] usually - common.<ref name=pmid22520044>{{Cite journal  | last1 = Huguet | first1 = J. | title = [Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice]. | journal = Actas Urol Esp | volume = 36 | issue = 9 | pages = 545-53 | month = Oct | year = 2012 | doi = 10.1016/j.acuro.2012.02.005 | PMID = 22520044 }}</ref>
*Spreads from the [[urinary bladder]] usually - common.<ref name=pmid22520044>{{Cite journal  | last1 = Huguet | first1 = J. | title = [Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice]. | journal = Actas Urol Esp | volume = 36 | issue = 9 | pages = 545-53 | month = Oct | year = 2012 | doi = 10.1016/j.acuro.2012.02.005 | PMID = 22520044 }}</ref>
*Identified by endoscopic loop biopsy<ref name=pmid17338657>{{Cite journal  | last1 = Liedberg | first1 = F. | last2 = Chebil | first2 = G. | last3 = Månsson | first3 = W. | title = Urothelial carcinoma in the prostatic urethra and prostate: current controversies. | journal = Expert Rev Anticancer Ther | volume = 7 | issue = 3 | pages = 383-90 | month = Mar | year = 2007 | doi = 10.1586/14737140.7.3.383 | PMID = 17338657 }}</ref> or [[TURP]].
*Identified by endoscopic loop biopsy<ref name=pmid17338657>{{Cite journal  | last1 = Liedberg | first1 = F. | last2 = Chebil | first2 = G. | last3 = Månsson | first3 = W. | title = Urothelial carcinoma in the prostatic urethra and prostate: current controversies. | journal = Expert Rev Anticancer Ther | volume = 7 | issue = 3 | pages = 383-90 | month = Mar | year = 2007 | doi = 10.1586/14737140.7.3.383 | PMID = 17338657 }}</ref> or [[TURP]].
Retrieved from "https://librepathology.org/wiki/Urothelial_carcinoma_of_the_urethra"