Difference between revisions of "Talk:Celiac sprue"
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===Final diagnosis=== | ===Final diagnosis=== | ||
A. Duodenum, biopsy - duodenum with moderate focal crypt hyperplasia and mild focal villous atrophy in keeping with celiac disease with: <br> | A. Duodenum, biopsy - duodenum with moderate focal crypt hyperplasia and mild focal villous atrophy in keeping with celiac disease with: <br> | ||
: i) modified | : i) modified Marsh grade 1. <br> | ||
B. Gastric antrum, biopsy - no pathologic diagnosis. <br> | B. Gastric antrum, biopsy - no pathologic diagnosis. <br> | ||
C. Gastric body, biopsy - no pathologic diagnosis. <br> | C. Gastric body, biopsy - no pathologic diagnosis. <br> | ||
D. Esophagus; biopsy - no pathologic diagnosis. <br> | D. Esophagus; biopsy - no pathologic diagnosis. <br> | ||
== Mild increase of IELs == | |||
<pre> | |||
SMALL BOWEL, BIOPSY: | |||
- SMALL BOWEL MUCOSA WITH MILDLY INCREASED INTRAEPITHELIAL LYMPHOCYTES | |||
(~30 LYMPHOCYTES/100 ENTEROCYTES) WITHOUT SIGNIFICANT CHANGES OF THE | |||
VILLOUS ARCHITECTURE, SEE COMMENT. | |||
- NEGATIVE FOR ACTIVE INFLAMMATION. | |||
- NEGATIVE FOR DYSPLASIA. | |||
COMMENT: | |||
The number of intraepithelial lymphocytes (IELs) in celiac disease is typically higher than | |||
40 per 100 enterocytes. A mild increase of IELs is a nonspecific finding. Serology for | |||
celiac disease could be considered, if not done. Clinical correlation is suggested. | |||
</pre> | |||
Latest revision as of 20:12, 25 February 2014
- See also: Talk:Esophagus.
Celiac sprue
Microscopic description
A. The sections shows small bowel mucosa with Brunner's glands and a moderate number of intraepithelial lymphocytes (~30-40 lymphocytes/100 enterocytes). There is focal mild blunting of the villi and moderate crypt hyperplasia. The intraepithelial lymphocytes are more prominent at the tips of the villi. The lamina propria contains a moderate number of plasma cells and lymphocytes, and rare eosinophils. There is no dysplasia.
B. The sections show normal antral-type gastric mucsoa.
C. The sections show normal body-type gastric mucosa.
D. The sections show normal esophageal-type mucosa.
Final diagnosis
A. Duodenum, biopsy - duodenum with moderate focal crypt hyperplasia and mild focal villous atrophy in keeping with celiac disease with:
- i) modified Marsh grade 1.
B. Gastric antrum, biopsy - no pathologic diagnosis.
C. Gastric body, biopsy - no pathologic diagnosis.
D. Esophagus; biopsy - no pathologic diagnosis.
Mild increase of IELs
SMALL BOWEL, BIOPSY: - SMALL BOWEL MUCOSA WITH MILDLY INCREASED INTRAEPITHELIAL LYMPHOCYTES (~30 LYMPHOCYTES/100 ENTEROCYTES) WITHOUT SIGNIFICANT CHANGES OF THE VILLOUS ARCHITECTURE, SEE COMMENT. - NEGATIVE FOR ACTIVE INFLAMMATION. - NEGATIVE FOR DYSPLASIA. COMMENT: The number of intraepithelial lymphocytes (IELs) in celiac disease is typically higher than 40 per 100 enterocytes. A mild increase of IELs is a nonspecific finding. Serology for celiac disease could be considered, if not done. Clinical correlation is suggested.