Clear cell carcinoma of the uterine cervix: Difference between revisions
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| Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg | | Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg | ||
| Width = | | Width = | ||
| Caption = Clear cell carcinoma of the gynecologic tract. [[H&E stain]]. | | Caption = Clear cell carcinoma of the gynecologic tract with focal clear cells. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid) | | Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[clear cell carcinoma of the vagina]], [[clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]] | ||
| Stains = | | Stains = PAS +ve, PASD -ve | ||
| IHC = | | IHC = CK7 +ve, ER -ve, PR -ve, CA-125 +ve, CEA -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = +/-diethylstilbestrol (DES) exposure | | Clinicalhx = +/-diethylstilbestrol (DES) exposure, "young" (median age ~38 years old) | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||