Peritumoural lymphocytic response: Difference between revisions
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[[Image:Peritumour lymphocytic response - low mag.jpg|thumb|right|Peritumoural lymphocytic response. [[H&E stain]].]] | [[Image:Peritumour lymphocytic response - very low mag.jpg|thumb|right|Peritumoural lymphocytic response. [[H&E stain]].]] | ||
'''Peritumoural lymphocytic response''' is an uncommon finding in [[colorectal carcinoma]] that is associated with a better prognosis | '''Peritumoural lymphocytic response''' is an uncommon finding in [[colorectal carcinoma]] that is associated with a better prognosis and [[Microsatellite instability in colorectal cancer|microsatellite instability]].<ref name=pmid7821914/> | ||
It is also known as '''Crohn's like reaction''',<ref name=pmid19825961>{{Cite journal | last1 = Ogino | first1 = S. | last2 = Nosho | first2 = K. | last3 = Irahara | first3 = N. | last4 = Meyerhardt | first4 = JA. | last5 = Baba | first5 = Y. | last6 = Shima | first6 = K. | last7 = Glickman | first7 = JN. | last8 = Ferrone | first8 = CR. | last9 = Mino-Kenudson | first9 = M. | title = Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. | journal = Clin Cancer Res | volume = 15 | issue = 20 | pages = 6412-20 | month = Oct | year = 2009 | doi = 10.1158/1078-0432.CCR-09-1438 | PMID = 19825961 }}</ref> '''Crohn's-like lymphoid reaction''' and '''Crohn-like response'''.<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2012/Colon_12protocol_3200.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2012/Colon_12protocol_3200.pdf]. Accessed on: 14 September 2012.</ref> | It is also known as '''Crohn's like reaction''',<ref name=pmid19825961>{{Cite journal | last1 = Ogino | first1 = S. | last2 = Nosho | first2 = K. | last3 = Irahara | first3 = N. | last4 = Meyerhardt | first4 = JA. | last5 = Baba | first5 = Y. | last6 = Shima | first6 = K. | last7 = Glickman | first7 = JN. | last8 = Ferrone | first8 = CR. | last9 = Mino-Kenudson | first9 = M. | title = Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. | journal = Clin Cancer Res | volume = 15 | issue = 20 | pages = 6412-20 | month = Oct | year = 2009 | doi = 10.1158/1078-0432.CCR-09-1438 | PMID = 19825961 }}</ref> '''Crohn's-like lymphoid reaction''' and '''Crohn-like response'''.<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2012/Colon_12protocol_3200.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2012/Colon_12protocol_3200.pdf]. Accessed on: 14 September 2012.</ref> | ||
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Note: | Note: | ||
*Should '''not''' be confused with [[intratumoural lymphocytic response]]. | *Should '''not''' be confused with [[Intratumoural lymphocytic response in colorectal carcinoma|intratumoural lymphocytic response]]. | ||
**The intratumoural lymphocytic response is associated with MSI-H cancers. | **The intratumoural lymphocytic response is associated with MSI-H cancers. | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Peritumour lymphocytic response - very low mag.jpg | PLR - very low mag. (WC) | |||
Image:Peritumour lymphocytic response - low mag.jpg | PLR - low mag. (WC) | Image:Peritumour lymphocytic response - low mag.jpg | PLR - low mag. (WC) | ||
Image:Peritumour lymphocytic response - intermed mag.jpg | PLR - intermed. mag. (WC) | Image:Peritumour lymphocytic response - intermed mag.jpg | PLR - intermed. mag. (WC) | ||
</gallery> | </gallery> | ||
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*[http://jcp.bmjjournals.com/content/62/8/679/F2.large.jpg Peritumour lymphocytic response in endometrial carcinoma (bmjjournals.com)]. | *[http://jcp.bmjjournals.com/content/62/8/679/F2.large.jpg Peritumour lymphocytic response in endometrial carcinoma (bmjjournals.com)]. | ||
*[http://ajcp.ascpjournals.org/content/134/3/478/F3.expansion.html Peritumour lymphocytic response in CRC (ascpjournals.org)].<ref name=pmid20716806>{{Cite journal | last1 = Ross | first1 = JS. | last2 = Torres-Mora | first2 = J. | last3 = Wagle | first3 = N. | last4 = Jennings | first4 = TA. | last5 = Jones | first5 = DM. | title = Biomarker-based prediction of response to therapy for colorectal cancer: current perspective. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 478-90 | month = Sep | year = 2010 | doi = 10.1309/AJCP2Y8KTDPOAORH | PMID = 20716806 | URL = http://ajcp.ascpjournals.org/content/134/3/478.full}}</ref> | *[http://ajcp.ascpjournals.org/content/134/3/478/F3.expansion.html Peritumour lymphocytic response in CRC (ascpjournals.org)].<ref name=pmid20716806>{{Cite journal | last1 = Ross | first1 = JS. | last2 = Torres-Mora | first2 = J. | last3 = Wagle | first3 = N. | last4 = Jennings | first4 = TA. | last5 = Jones | first5 = DM. | title = Biomarker-based prediction of response to therapy for colorectal cancer: current perspective. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 478-90 | month = Sep | year = 2010 | doi = 10.1309/AJCP2Y8KTDPOAORH | PMID = 20716806 | URL = http://ajcp.ascpjournals.org/content/134/3/478.full}}</ref> --> | ||
==See also== | ==See also== | ||
*[[Colorectal carcinoma]]. | *[[Colorectal carcinoma]]. | ||
*[[Crohn's disease]]. | |||
*[[Tumour-infiltrating lymphocytes]]. | |||
*[[Intraepithelial lymphocytes]]. | |||
==References== | ==References== | ||