Hemangioma of the liver: Difference between revisions
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*Benign.<ref name=pmid26361504>{{Cite journal | last1 = Bajenaru | first1 = N. | last2 = Balaban | first2 = V. | last3 = Săvulescu | first3 = F. | last4 = Campeanu | first4 = I. | last5 = Patrascu | first5 = T. | title = Hepatic hemangioma -review. | journal = J Med Life | volume = 8 Spec Issue | issue = | pages = 4-11 | month = | year = 2015 | doi = | PMID = 26361504 }}</ref> | *Benign.<ref name=pmid26361504>{{Cite journal | last1 = Bajenaru | first1 = N. | last2 = Balaban | first2 = V. | last3 = Săvulescu | first3 = F. | last4 = Campeanu | first4 = I. | last5 = Patrascu | first5 = T. | title = Hepatic hemangioma -review. | journal = J Med Life | volume = 8 Spec Issue | issue = | pages = 4-11 | month = | year = 2015 | doi = | PMID = 26361504 }}</ref> | ||
**Can be hard to differentiate from metastatic disease on imaging.<ref name=pmid11039718/> | **Can be hard to differentiate from metastatic disease on imaging.<ref name=pmid11039718/> | ||
*May cause [[congestive heart failure]] in infants - if large.<ref name=pmid26322113>{{Cite journal | last1 = Kayaalp | first1 = C. | last2 = Sabuncuoglu | first2 = MZ. | title = Embolization of Liver Hemangiomas. | journal = Hepat Mon | volume = 15 | issue = 8 | pages = e30334 | month = Aug | year = 2015 | doi = 10.5812/hepatmon.30334 | PMID = 26322113 }}</ref> | *May cause [[congestive heart failure]] in infants - if large.<ref name=pmid26322113>{{Cite journal | last1 = Kayaalp | first1 = C. | last2 = Sabuncuoglu | first2 = MZ. | title = Embolization of Liver Hemangiomas. | journal = Hepat Mon | volume = 15 | issue = 8 | pages = e30334 | month = Aug | year = 2015 | doi = 10.5812/hepatmon.30334 | PMID = 26322113 }}</ref> | ||
*May rupture and be life-threatening.<ref name=pmid19241936>{{Cite journal | last1 = Vokaer | first1 = B. | last2 = Kothonidis | first2 = K. | last3 = Delatte | first3 = P. | last4 = De Cooman | first4 = S. | last5 = Pector | first5 = JC. | last6 = Liberale | first6 = G. | title = Should ruptured liver haemangioma be treated by surgery or by conservative means? A case report. | journal = Acta Chir Belg | volume = 108 | issue = 6 | pages = 761-4 | month = | year = | doi = | PMID = 19241936 }}</ref> | |||
Clinical: | Clinical: | ||
*Do not grow in size - can be followed if small or medium size (<10 cm).<ref name=pmid26361504/> | *Do not grow in size - can be followed if small or medium size (<10 cm).<ref name=pmid26361504/> | ||
*Usually an incidental finding (incidentaloma) and often asymptomatic.<ref name=pmid26361504/> | |||
**Large lesions may present with upper abdominal pain. | |||
==Gross== | ==Gross== | ||
*Variable size. | *Variable size. | ||
*Well circumscribed. | *Well circumscribed. | ||
*Classically subcapsular.{{fact}} | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Channels lined by benign endothelium containing [[RBC]]s. | *Channels lined by benign endothelium containing [[RBC]]s. | ||
*Surrounding (non-endothelial) cells without significant atypia. | |||
DDx: | DDx: | ||
*[[Epithelioid hemangioendothelioma]]. | *[[Epithelioid hemangioendothelioma]] - atypical perivascular cells, classically with cytoplasmic vacuolization ("blister cells"). | ||
*[[Angiosarcoma]]. | *[[Angiosarcoma]]. | ||
*[[Metastatic disease]]. | *[[Metastatic disease]]. | ||
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- NEGATIVE for malignancy. | - NEGATIVE for malignancy. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show dilated vascular spaces containing red blood cells that are lined by endothelial cells without significant atypia. The vascular spaces are separated by bland fibrous tissue. | |||
Abnormal perivascular cells are not identified. The background liver is without atypia and does not have appreciable fat. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||