Difference between revisions of "Tubular adenoma of the urinary tract"

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'''Tubular adenoma of the urinary tract''' is a very rare premalignant lesion of the urinary tract that looks like a [[tubular adenoma of the gastrointestinal tract]].<ref name=pmid23664485>{{Cite journal  | last1 = Kao | first1 = CS. | last2 = Epstein | first2 = JI. | title = Tubular adenoma of the urinary tract: a newly described entity. | journal = Hum Pathol | volume = 44 | issue = 9 | pages = 1890-4 | month = Sep | year = 2013 | doi = 10.1016/j.humpath.2013.02.017 | PMID = 23664485 }}</ref>
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Tubular adenoma of the urinary tract -- low mag.jpg
| Width      =
| Caption    = Tubular adenoma of the urinary tract. [[H&E stain]].
| Synonyms  =
| Micro      = glands with pseudostratified hyperchromatic nuclei without maturation to the surface
| Subtypes  =
| LMDDx      = in situ [[adenocarcinoma of the urinary bladder]], [[adenocarcinoma of the urinary bladder]], metastatic [[adenocarcinoma]]
| Stains    =
| IHC        = [[CK20]] +ve, [[CDX2]] +ve, [[CK7]] -ve, [[GATA3]] -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = urinary tract - [[urinary bladder]], [[ureter]], renal pelvis
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Tubular adenoma of the urinary tract''' is a very rare lesion of the urinary tract that looks like a [[tubular adenoma of the gastrointestinal tract]].<ref name=pmid23664485>{{Cite journal  | last1 = Kao | first1 = CS. | last2 = Epstein | first2 = JI. | title = Tubular adenoma of the urinary tract: a newly described entity. | journal = Hum Pathol | volume = 44 | issue = 9 | pages = 1890-4 | month = Sep | year = 2013 | doi = 10.1016/j.humpath.2013.02.017 | PMID = 23664485 }}</ref>


==General==
*Very rare.
Note:
*''Villous adenoma of the urinary tract''<ref name=pmid11957151>{{Cite journal  | last1 = Seibel | first1 = JL. | last2 = Prasad | first2 = S. | last3 = Weiss | first3 = RE. | last4 = Bancila | first4 = E. | last5 = Epstein | first5 = JI. | title = Villous adenoma of the urinary tract: a lesion frequently associated with malignancy. | journal = Hum Pathol | volume = 33 | issue = 2 | pages = 236-41 | month = Feb | year = 2002 | doi =  | PMID = 11957151 }}</ref><ref name=pmid21114216>{{Cite journal  | last1 = Ratanarapee | first1 = S. | last2 = Uiprasertkul | first2 = M. | last3 = Pradniwat | first3 = K. | last4 = Soontrapa | first4 = S. | title = Villous adenoma of the urinary bladder: a case report. | journal = J Med Assoc Thai | volume = 93 | issue = 11 | pages = 1336-9 | month = Nov | year = 2010 | doi =  | PMID = 21114216 }}</ref> and ''tubulovillous adenoma of the urinary tract''<ref name=pmid10430279>{{Cite journal  | last1 = Adegboyega | first1 = PA. | last2 = Adesokan | first2 = A. | title = Tubulovillous adenoma of the urinary bladder. | journal = Mod Pathol | volume = 12 | issue = 7 | pages = 735-8 | month = Jul | year = 1999 | doi =  | PMID = 10430279 }}</ref> are also reported.
==Microscopic==
Features:
*Glands with pseudostratified hyperchromatic nuclei without maturation to the surface.
DDx:
*In situ [[adenocarcinoma of the urinary bladder]].
*[[Adenocarcinoma of the urinary bladder]].
*Metastatic [[adenocarcinoma]], e.g. [[colorectal adenocarcinoma]].
===Images===
<gallery>
Image: Tubular adenoma of the urinary tract -- very low mag.jpg |TAUT - very low mag. (WC)
Image: Tubular adenoma of the urinary tract -- low mag.jpg |TAUT - low mag. (WC)
Image: Tubular adenoma of the urinary tract -- intermed mag.jpg |TAUT - intermed. mag. (WC)
Image: Tubular adenoma of the urinary tract -- high mag.jpg |TAUT - high mag. (WC)
</gallery>
==IHC==
Features:<ref name=pmid23664485/>
*[[CK20]] +ve.
*[[CDX2]] +ve.
*[[CK7]] -ve.
*[[GATA3]] -ve.


==See also==
==See also==

Latest revision as of 01:42, 18 November 2015

Tubular adenoma of the urinary tract
Diagnosis in short

Tubular adenoma of the urinary tract. H&E stain.
LM glands with pseudostratified hyperchromatic nuclei without maturation to the surface
LM DDx in situ adenocarcinoma of the urinary bladder, adenocarcinoma of the urinary bladder, metastatic adenocarcinoma
IHC CK20 +ve, CDX2 +ve, CK7 -ve, GATA3 -ve
Site urinary tract - urinary bladder, ureter, renal pelvis
Prevalence uncommon
Prognosis benign

Tubular adenoma of the urinary tract is a very rare lesion of the urinary tract that looks like a tubular adenoma of the gastrointestinal tract.[1]

General

  • Very rare.

Note:

  • Villous adenoma of the urinary tract[2][3] and tubulovillous adenoma of the urinary tract[4] are also reported.

Microscopic

Features:

  • Glands with pseudostratified hyperchromatic nuclei without maturation to the surface.

DDx:

Images

  • TAUT - very low mag. (WC)

  • TAUT - low mag. (WC)

  • TAUT - intermed. mag. (WC)

  • TAUT - high mag. (WC)

IHC

Features:[1]

See also

References

  1. ↑ 1.0 1.1 Kao, CS.; Epstein, JI. (Sep 2013). "Tubular adenoma of the urinary tract: a newly described entity.". Hum Pathol 44 (9): 1890-4. doi:10.1016/j.humpath.2013.02.017. PMID 23664485.
  2. ↑ Seibel, JL.; Prasad, S.; Weiss, RE.; Bancila, E.; Epstein, JI. (Feb 2002). "Villous adenoma of the urinary tract: a lesion frequently associated with malignancy.". Hum Pathol 33 (2): 236-41. PMID 11957151.
  3. ↑ Ratanarapee, S.; Uiprasertkul, M.; Pradniwat, K.; Soontrapa, S. (Nov 2010). "Villous adenoma of the urinary bladder: a case report.". J Med Assoc Thai 93 (11): 1336-9. PMID 21114216.
  4. ↑ Adegboyega, PA.; Adesokan, A. (Jul 1999). "Tubulovillous adenoma of the urinary bladder.". Mod Pathol 12 (7): 735-8. PMID 10430279.
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