Renal cell carcinoma with sarcomatoid differentiation: Difference between revisions
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==General== | ==General== | ||
Features:<ref name=pmid11224597>{{Cite journal | last1 = de Peralta-Venturina | first1 = M. | last2 = Moch | first2 = H. | last3 = Amin | first3 = M. | last4 = Tamboli | first4 = P. | last5 = Hailemariam | first5 = S. | last6 = Mihatsch | first6 = M. | last7 = Javidan | first7 = J. | last8 = Stricker | first8 = H. | last9 = Ro | first9 = JY. | title = Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. | journal = Am J Surg Pathol | volume = 25 | issue = 3 | pages = 275-84 | month = Mar | year = 2001 | doi = | PMID = 11224597 }}</ref> | Features:<ref name=pmid11224597>{{Cite journal | last1 = de Peralta-Venturina | first1 = M. | last2 = Moch | first2 = H. | last3 = Amin | first3 = M. | last4 = Tamboli | first4 = P. | last5 = Hailemariam | first5 = S. | last6 = Mihatsch | first6 = M. | last7 = Javidan | first7 = J. | last8 = Stricker | first8 = H. | last9 = Ro | first9 = JY. | title = Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. | journal = Am J Surg Pathol | volume = 25 | issue = 3 | pages = 275-84 | month = Mar | year = 2001 | doi = | PMID = 11224597 }}</ref> | ||
*Not recognized as a distinct entity in 2004 WHO classification | *'''Not''' recognized as a distinct entity in 2004 WHO classification<ref name=pmid16442207>{{Cite journal | last1 = Lopez-Beltran | first1 = A. | last2 = Scarpelli | first2 = M. | last3 = Montironi | first3 = R. | last4 = Kirkali | first4 = Z. | title = 2004 WHO classification of the renal tumors of the adults. | journal = Eur Urol | volume = 49 | issue = 5 | pages = 798-805 | month = May | year = 2006 | doi = 10.1016/j.eururo.2005.11.035 | PMID = 16442207 }}</ref> and after. | ||
**It is considered an indicator of progression. | **It is considered an indicator of progression. | ||
**Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal | last1 = Cangiano | first1 = T. | last2 = Liao | first2 = J. | last3 = Naitoh | first3 = J. | last4 = Dorey | first4 = F. | last5 = Figlin | first5 = R. | last6 = Belldegrun | first6 = A. | title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. | journal = J Clin Oncol | volume = 17 | issue = 2 | pages = 523-8 | month = Feb | year = 1999 | doi = | PMID = 10080595 | URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref> | **Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal | last1 = Cangiano | first1 = T. | last2 = Liao | first2 = J. | last3 = Naitoh | first3 = J. | last4 = Dorey | first4 = F. | last5 = Figlin | first5 = R. | last6 = Belldegrun | first6 = A. | title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. | journal = J Clin Oncol | volume = 17 | issue = 2 | pages = 523-8 | month = Feb | year = 1999 | doi = | PMID = 10080595 | URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref> | ||
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*[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition. | *[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition. | ||
*Most commonly seen in association with [[clear cell renal cell carcinoma]]<ref name=pmid22234634/> or [[chromophobe RCC]].<ref name=pmid15087662>{{Cite journal | last1 = Cheville | first1 = JC. | last2 = Lohse | first2 = CM. | last3 = Zincke | first3 = H. | last4 = Weaver | first4 = AL. | last5 = Leibovich | first5 = BC. | last6 = Frank | first6 = I. | last7 = Blute | first7 = ML. | title = Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 435-41 | month = Apr | year = 2004 | doi = | PMID = 15087662 }}</ref><ref name=pmid9331291>{{Cite journal | last1 = Akhtar | first1 = M. | last2 = Tulbah | first2 = A. | last3 = Kardar | first3 = AH. | last4 = Ali | first4 = MA. | title = Sarcomatoid renal cell carcinoma: the chromophobe connection. | journal = Am J Surg Pathol | volume = 21 | issue = 10 | pages = 1188-95 | month = Oct | year = 1997 | doi = | PMID = 9331291 }}</ref> | *Most commonly seen in association with [[clear cell renal cell carcinoma]]<ref name=pmid22234634/> or [[chromophobe RCC]].<ref name=pmid15087662>{{Cite journal | last1 = Cheville | first1 = JC. | last2 = Lohse | first2 = CM. | last3 = Zincke | first3 = H. | last4 = Weaver | first4 = AL. | last5 = Leibovich | first5 = BC. | last6 = Frank | first6 = I. | last7 = Blute | first7 = ML. | title = Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 435-41 | month = Apr | year = 2004 | doi = | PMID = 15087662 }}</ref><ref name=pmid9331291>{{Cite journal | last1 = Akhtar | first1 = M. | last2 = Tulbah | first2 = A. | last3 = Kardar | first3 = AH. | last4 = Ali | first4 = MA. | title = Sarcomatoid renal cell carcinoma: the chromophobe connection. | journal = Am J Surg Pathol | volume = 21 | issue = 10 | pages = 1188-95 | month = Oct | year = 1997 | doi = | PMID = 9331291 }}</ref> | ||
==Gross== | |||
*White solid area. | |||
DDx: | |||
*Degenerative changes. | |||
==Microscopic== | ==Microscopic== | ||
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*Retroperitoneal [[sarcoma]]. | *Retroperitoneal [[sarcoma]]. | ||
*[[Renal mucinous tubular and spindle cell carcinoma]]. | *[[Renal mucinous tubular and spindle cell carcinoma]]. | ||
===Images=== | ===Images=== | ||
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*[[Kidney tumours]]. | *[[Kidney tumours]]. | ||
*[[Renal cell carcinoma with rhabdoid change]]. | *[[Renal cell carcinoma with rhabdoid change]]. | ||
*[[Sarcomatoid carcinoma]]. | |||
==References== | ==References== | ||