Adenosis of the prostate gland: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Adenosis of prostate -- low mag.jpg | |||
| Width = | |||
| Caption = Adenosis of prostate gland. [[H&E stain]]. | |||
| Synonyms = atypical adenomatous hyperplasia | |||
| Micro = glandular crowding, bland nuclear features (lack prominent nucleoli, lack nuclear enlargement) | |||
| Subtypes = | |||
| LMDDx = [[prostatic adenocarcinoma]] (esp. [[foamy gland adenocarcinoma]]), [[bulbourethral gland]] | |||
| Stains = | |||
| IHC = patchy basal cell markers (e.g. p63 +ve, CK5/6 +ve), AMACR -ve, ERG -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = not evident | |||
| Grossing = | |||
| Site = [[prostate gland]] - transistion zone | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = none | |||
}} | |||
'''Adenosis of the prostate gland''', also '''adenosis of the prostate''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | '''Adenosis of the prostate gland''', also '''adenosis of the prostate''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | ||
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*May be mistaken for [[prostatic adenocarcinoma]].<ref name=pmid22212076>{{Cite journal | last1 = Epstein | first1 = JI. | title = Diagnosis of limited adenocarcinoma of the prostate. | journal = Histopathology | volume = 60 | issue = 1 | pages = 28-40 | month = Jan | year = 2012 | doi = 10.1111/j.1365-2559.2011.03990.x | PMID = 22212076 }}</ref> | *May be mistaken for [[prostatic adenocarcinoma]].<ref name=pmid22212076>{{Cite journal | last1 = Epstein | first1 = JI. | title = Diagnosis of limited adenocarcinoma of the prostate. | journal = Histopathology | volume = 60 | issue = 1 | pages = 28-40 | month = Jan | year = 2012 | doi = 10.1111/j.1365-2559.2011.03990.x | PMID = 22212076 }}</ref> | ||
*Lesion of the transistion zone of the prostate.<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | *Lesion of the transistion zone of the prostate.<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | ||
*'''Not''' considered a precursor of [[prostatic adenocarcinoma]].<ref name=pmid23664537>{{Cite journal | last1 = Green | first1 = WM. | last2 = Hicks | first2 = JL. | last3 = De Marzo | first3 = A. | last4 = Illei | first4 = PP. | last5 = Epstein | first5 = JI. | title = Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate. | journal = Hum Pathol | volume = 44 | issue = 9 | pages = 1895-901 | month = Sep | year = 2013 | doi = 10.1016/j.humpath.2013.02.019 | PMID = 23664537 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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**[[Foamy gland adenocarcinoma]] - typically has intraluminal crystalloids. | **[[Foamy gland adenocarcinoma]] - typically has intraluminal crystalloids. | ||
*[[Bulbourethral gland]] - at apex of prostate. | *[[Bulbourethral gland]] - at apex of prostate. | ||
*Atypical sclerosing adenosis of the prostate.<ref name=pmid20459573>{{Cite journal | last1 = Cheng | first1 = L. | last2 = Bostwick | first2 = DG. | title = Atypical sclerosing adenosis of the prostate: a rare mimic of adenocarcinoma. | journal = Histopathology | volume = 56 | issue = 5 | pages = 627-31 | month = Apr | year = 2010 | doi = 10.1111/j.1365-2559.2010.03525.x | PMID = 20459573 }}</ref> | |||
===Images=== | |||
<gallery> | |||
Image: Adenosis of prostate -- very low mag.jpg | Adenosis - very low mag. | |||
Image: Adenosis of prostate -- low mag.jpg | Adenosis - low mag. | |||
Image: Adenosis of prostate -- intermed mag.jpg | Adenosis - intermed. mag. | |||
Image: Adenosis of prostate -- high mag.jpg | Adenosis - high mag. | |||
Image: Adenosis of prostate - alt -- intermed mag.jpg | Adenosis - intermed. mag. | |||
Image: Adenosis of prostate - alt -- high mag.jpg | Adenosis - high mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||
| Line 22: | Line 65: | ||
*p63 +ve. ‡ | *p63 +ve. ‡ | ||
*AMACR -ve. | *AMACR -ve. | ||
*ERG -ve.<ref name=pmid23664537>{{Cite journal | last1 = Green | first1 = WM. | last2 = Hicks | first2 = JL. | last3 = De Marzo | first3 = A. | last4 = Illei | first4 = PP. | last5 = Epstein | first5 = JI. | title = Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate. | journal = Hum Pathol | volume = 44 | issue = 9 | pages = 1895-901 | month = Sep | year = 2013 | doi = 10.1016/j.humpath.2013.02.019 | PMID = 23664537 }}</ref> | |||
Notes: | Notes: | ||
*‡ Often patchy - some glands in a group may lack basal cells. | *‡ Often patchy - some glands in a group may lack basal cells. | ||
===Images=== | |||
<gallery> | |||
Image: Adenosis of prostate - amacr-ck5 6 -- very low mag.jpg | Adenosis - very low mag. | |||
Image: Adenosis of prostate - amacr-ck5 6 -- low mag.jpg | Adenosis - low mag. | |||
Image: Adenosis of prostate - amacr-ck5 6 -- intermed mag.jpg | Adenosis - intermed. mag. | |||
Image: Adenosis of prostate - amacr-ck5 6 -- high mag.jpg | Adenosis - high mag. | |||
Image: Adenosis of prostate - amacr-ck5 6 - alt -- intermed mag.jpg | Adenosis - intermed. mag. | |||
Image: Adenosis of prostate - amacr-ck5 6- alt -- high mag.jpg | Adenosis - high mag. | |||
</gallery> | |||
==Sign out== | |||
*Typically not reported explicitly. | |||
*IHC should be reported if done. | |||
==See also== | ==See also== | ||