Lymphoma: Difference between revisions
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====Histologic terms==== | ====Histologic terms==== | ||
*Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. | *Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. | ||
*Auer rods = | *[[Auer rods]] = [[acute myeloid leukemia]]. | ||
**Granular cytoplasmic rod (0.5-1 x4-6 micrometres). | **Granular cytoplasmic rod (0.5-1 x4-6 micrometres). | ||
**Not pathognomonic. | |||
*Reed-Sternberg cells = [[Hodgkin's lymphoma]]. | *Reed-Sternberg cells = [[Hodgkin's lymphoma]]. | ||
**Large cell - very large nucleus. | **Large cell - very large nucleus. | ||
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Others: | Others: | ||
*AE1/AE3 -- to r/o carcinoma. | *[[AE1/AE3]] -ve -- to r/o carcinoma. | ||
====T cell markers==== | ====T cell markers==== | ||
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**''Hyperviscosity syndrome''. | **''Hyperviscosity syndrome''. | ||
**Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8|325}}</ref> | **Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8|325}}</ref> | ||
**Over 90% of patients have the MYD88 L265P somatic mutation.<ref name=pmid=22931316>{{cite journal |vauthors=Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR |title=MYD88 L265P somatic mutation in Waldenström's macroglobulinemia |journal=N Engl J Med |volume=367 |issue=9 |pages=826–33 |date=August 2012 |pmid=22931316 |doi=10.1056/NEJMoa1200710 |url=}}</ref> | |||
====Clinical==== | ====Clinical==== | ||