Difference between revisions of "Extrarenal malignant rhabdoid tumour"
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*Variable architecture. | *Variable architecture. | ||
*Round cells. | *Round cells. | ||
*Eccentric vesicular nucleus. | *Eccentric [[vesicular nucleus]]. | ||
*Prominent [[nucleolus]] -- '''key feature'''. | *Prominent [[nucleolus]] -- '''key feature'''. | ||
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==IHC== | ==IHC== | ||
* | *[[INI1]] (SMARCB1) -ve. | ||
**[[AKA]] BAF47. | **[[AKA]] BAF47. | ||
Latest revision as of 20:26, 21 September 2015
Extrarenal malignant rhabdoid tumour is a rare malignant tumour typically seen in children.
It is essentially identical to the renal malignant rhabdoid tumour.[1]
General
- Usually children < 2 years old.
- Very poor prognosis ~ mean survival in one series 9 months.[2]
- In the CNS it is known as atypical teratoid-rhabdoid tumour.[1]
Microscopic
Features:[1]
- Variable architecture.
- Round cells.
- Eccentric vesicular nucleus.
- Prominent nucleolus -- key feature.
DDx:
IHC
Others:[5]
- Vimentin +ve.
- EMA +ve.
- AE1/AE3 +ve.
- CAM5.2 +ve.
See also
References
- ↑ 1.0 1.1 1.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 627. ISBN 978-0781765275.
- ↑ Uwineza, A.; Gill, H.; Buckley, P.; Owens, C.; Capra, M.; O'Sullivan, C.; McDermott, M.; Brett, F. et al. (Sep 2014). "Rhabdoid tumor: the Irish experience 1986-2013.". Cancer Genet 207 (9): 398-402. doi:10.1016/j.cancergen.2014.05.015. PMID 25085603.
- ↑ Liang, L.; Tatevian, N.; Bhattacharjee, M.; Tsao, K.; Hicks, J. (Aug 2014). "Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation.". World J Clin Cases 2 (8): 367-72. doi:10.12998/wjcc.v2.i8.367. PMID 25133149.
- ↑ Ishida, M.; Iwai, M.; Yoshida, K.; Kagotani, A.; Okabe, H. (2014). "Rhabdoid melanoma: a case report with review of the literature.". Int J Clin Exp Pathol 7 (2): 840-3. PMID 24551314.
- ↑ Wang, H.; Ma, Y.; Li, J.; Zhang, D.; Wu, B.; Fang, C.; Chen, L. (Dec 2014). "[Extrarenal malignant rhabdoid tumor of childhood: a clinicopathologic analysis of 8 cases].". Zhonghua Bing Li Xue Za Zhi 43 (12): 805-8. PMID 25623976.