Squamous cell carcinoma of the penis: Difference between revisions
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| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = HPV-related SCC, Non-HPV-related SCC | ||
| LMDDx = [[penile intraepithelial neoplasia]], [[pseudoepitheliomatous hyperplasia]] | | LMDDx = [[penile intraepithelial neoplasia]], [[pseudoepitheliomatous hyperplasia]] | ||
| Stains = | | Stains = | ||
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*[[Penile intraepithelial neoplasia]] (squamous dysplasia). | *[[Penile intraepithelial neoplasia]] (squamous dysplasia). | ||
*[[Pseudoepitheliomatous hyperplasia]]. | *[[Pseudoepitheliomatous hyperplasia]]. | ||
===Subtyping=== | |||
*''Non-HPV-related squamous cell carcinoma. | |||
**p16 -ve, p53 +ve.{{fact}} | |||
*''HPV-related squamous cell carcinoma''. | |||
**p16 +ve, p53 -ve.{{fact}} | |||
===Grading=== | ===Grading=== | ||
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==Sign out== | ==Sign out== | ||
===Biopsy=== | |||
<pre> | |||
Penis, Biopsy: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, well differentiated. | |||
Comment: | |||
The tumour has differentiated penile intraepithelial neoplasia adjacent to it. The tumour is p16 negative and p53 positive. | |||
</pre> | |||
===Resection=== | |||
<pre> | <pre> | ||
Tip of Penis, Partial Penectomy: | Tip of Penis, Partial Penectomy: | ||
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invasion is seen. The staging is unchanged. | invasion is seen. The staging is unchanged. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show a malignant tumour with moderate to severe anisonucleosis. It focally underlies keratinizing epithelium that matures to the surface. Intracellular bridges are present focally. Keratinization is present. Mitotic activity is easily identified. | |||
==See also== | ==See also== | ||