Talk:Congenital heart disease

Muscle excision

Microscopic

A. The sections show normal cardiac myocytes and mild endocardial fibrosis, covered by benign endothelial cells. There is no inflammation and no haphazard arrangement of muscle fibres.

B. The sections show cardiac myocytes and mild endocardial fibrosis, covered by benign endothelial cells. There is focal myofiber replacement by fibrous tissue with reactive hypertrophy (including increase of fiber size and nuclear size) of the remaining fibres. There is no inflammation and no haphazard arrangement of muscle fibres.

C. The section shows a laminated thrombus with focal calcifications and entrapped blood constituents. Special stains (GMS, Gram, PAS-D) did demonstrate micro-organisms.

Final diagnosis

A. Heart, right ventricle, muscle excision - mild endocardial fibrosis.

B. Heart, ventricular septum, muscle excision - mild endocardial fibrosis and focal hypertrophic changes.

C. Infundibulum clot, excision - laminated thrombus with focal calcification.

Septectomy

See also: Talk:Thymus.

Microscopic

The sections show fibrous tissue and cardiac muscle covered by endothelium on two sides. There is mild muscle fibre hypertrophy with focal nuclear enlargement and mild endocardial fibroelastosis. There is no inflammation and no haphazard arrangement of muscle fibres.

Final diagnosis

Heart, atrial septum, septectomy - Mild endocardial fibroelastosis and mild hypertrophic changes.

TOF

Microscopic description

A. The section shows thymus with normal cortical and medullary development. The corticomedullary junction is well demarcated; however, there is an increase in histiocytes within the cortex and focal degenerative changes of thymic corpuscles. There is no depletion of cortical lymphocytes.

B. The sections show fragments of normal cardiac myocytes, in part, covered by benign endothelial cells, and, focally, thick bands of fibrous tissue and fibroelastic tissue. There is no inflammation and no haphazard arrangement of muscle fibres.

There is an unremarkable piece of a large elastic artery, with attached connective tissue (consisting predominantly of adipocytes, some fibrous tissue and fragments of nerve).

There are fragments of laminated connective tissue covered by endothelium, consisting of fibrous tissue, elastic fibres, and scant myxomatous material (possible valve fragment).

Final diagnosis

A. Thymus, incidental thymectomy - Architecturally normal thymus with mild physiologic stress effects.

B. Cardiac muscle, right ventricle musle bundle (RVMB), biopsy -
i) Cardiac muscle with fibroelastosis and endocardial fibrosis.
ii) Large elastic artery with attached connective tissue.
iii) Valve-like material (see microscopic description).