Difference between revisions of "Myxopapillary ependymoma"

From Libre Pathology
Jump to navigation Jump to search
(touch)
 
(7 intermediate revisions by 2 users not shown)
Line 1: Line 1:
#redirect [[Ependymoma#Myxopapillary_ependymoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Myxopapillary_ependymoma_-_very_high_mag.jpg
| Width      =
| Caption    = Myxopapillary ependymoma. [[HPS stain]].
| Synonyms  =
| Micro      = Papillary tumor cells around vascular myxoid matrix
| Subtypes  = subtype of [[ependymoma]]
| LMDDx      = [[chordoma]], [[myxoid chondrosarcoma]], [[paraganglioma]], papillary [[adenocarcinoma]]
| Stains    = Alcian blue +ve
| IHC        = GFAP +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = usually lumbar spinal cord
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good (WHO Grade I)
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Mxyopapillary Ependymoma''', is a low-grade [[Ependymoma]]. It is nearly always associated with [[cauda equina]] and [[filum terminale]].
 
==General==
*Low-grade [[ependymoma]] - ''WHO Grade I'' by definition.
*Classically in the spinal cord of adults.
* Approx 9-13% of all ependymal tumors.<ref>{{Cite journal  | last1 = Schiffer | first1 = D. | last2 = Chiò | first2 = A. | last3 = Giordana | first3 = MT. | last4 = Migheli | first4 = A. | last5 = Palma | first5 = L. | last6 = Pollo | first6 = B. | last7 = Soffietti | first7 = R. | last8 = Tribolo | first8 = A. | title = Histologic prognostic factors in ependymoma. | journal = Childs Nerv Syst | volume = 7 | issue = 4 | pages = 177-82 | month = Aug | year = 1991 | doi =  | PMID = 1933913 }}</ref>
*Associated with back pain.
*Enhancing mass
 
==Gross==
*Soft.
*Gray.
*Discrete masses.
*Often encapsulated.
*Subtotal resected tumors may spread throughout the neuraxis.
 
<gallery>
File:AFIP405714G-MYXOPAPILLARY EPENDYMOMA.jpg | Myxopapillary ependymoma in the filum terminale (Dr. E. Michael Scott, Boston, MA).
File:Myxopapillary_ependymoma_1.jpg | Mxyopapillary Ependymoma in the spinal cord, cross section (AFIP)
</gallery>
 
==Microscopic==
Features:
*Papillary appearance.
*Perivascular pseudorosettes:
**Cuboidal to elongated tumor cells.
**Radially arranged around vascular cores.
*Myxoid material surround blood vessels.
*Microcysts.
*Low mitotic activity.
 
Note:
Cases with extensive sclerosis may mimic degenerative changes. <ref>{{Cite journal  | last1 = Schittenhelm | first1 = J. | last2 = Becker | first2 = R. | last3 = Capper | first3 = D. | last4 = Meyermann | first4 = R. | last5 = Iglesias-Rozas | first5 = JR. | last6 = Kaminsky | first6 = J. | last7 = Mittelbronn | first7 = M. | title = The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature. | journal = Clin Neuropathol | volume = 27 | issue = 1 | pages = 21-8 | month =  | year =  | doi =  | PMID = 18257471 }}</ref>
 
DDx:
* [[Chordoma]].
* [[Myxoid chondrosarcoma]].
* [[Paraganglioma]].
* Papillary [[adenocarcinoma]].
 
===Images===
<gallery>
File:Myxopapillary_ependymoma.jpg | Mxyopapillary Ependymoma, HE Smear (AFIP)
File:Myxopapillary_ependymoma_-_intermed_mag.jpg  | Mxyopapillary Ependymoma, low magnification (WC/Nephron)
File:Myxopapillary_ependymoma-HE.jpg | Intermediate magnification (WC/jensflorian)
File:Myxopapillary_ependymoma_-_very_high_mag.jpg | High magnification (WC/Nephron)
File:Myxopapillary_ependymoma_HE_x40.jpg | Mxyopapillary Ependymoma, vascular sclerosis (WC/jensflorian)
File:Myxopapillary_Ependymoma_Alcian-blue.jpg | Alcian-blue staining highlighting the mucinous matrix (WC/jensflorian)
</gallery>
*[http://commons.wikimedia.org/wiki/File:Myxopapillary_ependymoma_-_high_mag.jpg Myxopapillary ependymoma - high mag. (WC)].
*[http://careers.bmj.com/article-images/cf0708.f2_default.gif Myxopapillary ependymoma (bmj.com)] - part of [http://careers.bmj.com/careers/advice/view-article.html?id=351 careers.bmj.com article on paediatric pathology].
*[http://commons.wikimedia.org/wiki/File:Myxopapillary_ependymoma.jpg Myxopapillary ependymoma - cytology (WC)].
*[http://path.upmc.edu/cases/case626.html Myxopapillary ependymoma - several images (upmc.edu)].
 
==IHC==
* GFAP+ve.
* S-100+ve.
* MIB-1 <1%.
 
==Molecular==
* Poorly characterized.
* No consistent abberations.
 
==See also==
*[[Neuropathology tumours]].
*[[Ependymoma]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Neuropathology tumours]]

Latest revision as of 04:11, 2 May 2015

Myxopapillary ependymoma
Diagnosis in short

Myxopapillary ependymoma. HPS stain.
LM Papillary tumor cells around vascular myxoid matrix
Subtypes subtype of ependymoma
LM DDx chordoma, myxoid chondrosarcoma, paraganglioma, papillary adenocarcinoma
Stains Alcian blue +ve
IHC GFAP +ve
Site usually lumbar spinal cord
Prognosis good (WHO Grade I)

Mxyopapillary Ependymoma, is a low-grade Ependymoma. It is nearly always associated with cauda equina and filum terminale.

General

  • Low-grade ependymoma - WHO Grade I by definition.
  • Classically in the spinal cord of adults.
  • Approx 9-13% of all ependymal tumors.[1]
  • Associated with back pain.
  • Enhancing mass

Gross

  • Soft.
  • Gray.
  • Discrete masses.
  • Often encapsulated.
  • Subtotal resected tumors may spread throughout the neuraxis.

  • Myxopapillary ependymoma in the filum terminale (Dr. E. Michael Scott, Boston, MA).

  • Mxyopapillary Ependymoma in the spinal cord, cross section (AFIP)

Microscopic

Features:

  • Papillary appearance.
  • Perivascular pseudorosettes:
    • Cuboidal to elongated tumor cells.
    • Radially arranged around vascular cores.
  • Myxoid material surround blood vessels.
  • Microcysts.
  • Low mitotic activity.

Note: Cases with extensive sclerosis may mimic degenerative changes. [2]

DDx:

Images

  • Mxyopapillary Ependymoma, HE Smear (AFIP)

  • Mxyopapillary Ependymoma, low magnification (WC/Nephron)

  • Intermediate magnification (WC/jensflorian)

  • High magnification (WC/Nephron)

  • Mxyopapillary Ependymoma, vascular sclerosis (WC/jensflorian)

  • Alcian-blue staining highlighting the mucinous matrix (WC/jensflorian)

IHC

  • GFAP+ve.
  • S-100+ve.
  • MIB-1 <1%.

Molecular

  • Poorly characterized.
  • No consistent abberations.

See also

References

  1. ↑ Schiffer, D.; Chiò, A.; Giordana, MT.; Migheli, A.; Palma, L.; Pollo, B.; Soffietti, R.; Tribolo, A. (Aug 1991). "Histologic prognostic factors in ependymoma.". Childs Nerv Syst 7 (4): 177-82. PMID 1933913.
  2. ↑ Schittenhelm, J.; Becker, R.; Capper, D.; Meyermann, R.; Iglesias-Rozas, JR.; Kaminsky, J.; Mittelbronn, M.. "The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature.". Clin Neuropathol 27 (1): 21-8. PMID 18257471.
Retrieved from "https://librepathology.org/w/index.php?title=Myxopapillary_ependymoma&oldid=37894"