Difference between revisions of "Thyroid-like follicular carcinoma of the kidney"

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'''Thyroid-like follicular carcinoma of the kidney''' is a recently described rare [[kidney tumour]].   
'''Thyroid-like follicular carcinoma of the kidney''', also '''thyroid-like follicular renal cell carcinoma''' (abbreviated '''TLF-RCC''' or '''TLFRCC'''), is a recently described rare [[kidney tumour]].   


It is considered an emerging entity by the ''[[Vancouver classification|Vancouver modification of the 2004 WHO classification of renal neoplasia]]''.<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>
It is considered an emerging entity by the ''[[Vancouver classification|Vancouver modification of the 2004 WHO classification of renal neoplasia]]''.<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>


==General==
==General==
*Extremely rare.
*Extremely rare - less than 15 cases reported in the literature.<ref name=pmid24025519/>
*Large age range (29-83 years old).
 
==Gross==
*Solid, brown and well circumscribed.


==Microscopic==
==Microscopic==
Features:
Features:<ref name=pmid24025519/>
*Thyroid follicule-like structures with eosinophilic material.
*Thyroid follicule-like structures - both macrofollicular and/or microfollicular. 
**Contain dense-appearing eosinophilic material.
*Encapuslated.
*Nuclei round and regular with prominent nucleoli ([[ISUP nucleolar grade]] 2 or 3).
 
DDx:
*Metastatic carcinoma.
**[[Follicular thyroid carcinoma]].
**[[Papillary thyroid carcinoma follicular variant]].
 
===Images===
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190304/figure/Fig3/ TLF-RCC (nih.gov)].<ref name=pmid25293503>{{Cite journal  | last1 = Ghaouti | first1 = M. | last2 = Roquet | first2 = L. | last3 = Baron | first3 = M. | last4 = Pfister | first4 = C. | last5 = Sabourin | first5 = JC. | title = Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature. | journal = Diagn Pathol | volume = 9 | issue = 1 | pages = 186 | month =  | year = 2014 | doi = 10.1186/s13000-014-0186-8 | PMID = 25293503 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123569/figure/fig2/ TLF-RCC (nih.gov)].<ref name=pmid25133003>{{Cite journal  | last1 = Wu | first1 = WW. | last2 = Chu | first2 = JT. | last3 = Nael | first3 = A. | last4 = Rezk | first4 = SA. | last5 = Romansky | first5 = SG. | last6 = Shane | first6 = L. | title = Thyroid-like follicular carcinoma of the kidney in a young patient with history of pediatric acute lymphoblastic leukemia. | journal = Case Rep Pathol | volume = 2014 | issue =  | pages = 313974 | month =  | year = 2014 | doi = 10.1155/2014/313974 | PMID = 25133003 }}</ref>
 
==IHC==
Features:<ref name=pmid24025519/>
*TTF-1 -ve.
*Thyroglobulin -ve.
*CK7 +ve/-ve.
*PAX8 +ve/-ve.


==See also==
==See also==
*[[Kidney tumours]].
*[[Kidney tumours]].
*[[Thyroid gland]].


==References==
==References==
{{Reflist|2}}
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Kidney tumours]]
[[Category:Kidney tumours]]

Latest revision as of 21:20, 14 March 2016

Thyroid-like follicular carcinoma of the kidney, also thyroid-like follicular renal cell carcinoma (abbreviated TLF-RCC or TLFRCC), is a recently described rare kidney tumour.

It is considered an emerging entity by the Vancouver modification of the 2004 WHO classification of renal neoplasia.[1]

General

  • Extremely rare - less than 15 cases reported in the literature.[1]
  • Large age range (29-83 years old).

Gross

  • Solid, brown and well circumscribed.

Microscopic

Features:[1]

  • Thyroid follicule-like structures - both macrofollicular and/or microfollicular.
    • Contain dense-appearing eosinophilic material.
  • Encapuslated.
  • Nuclei round and regular with prominent nucleoli (ISUP nucleolar grade 2 or 3).

DDx:

Images

IHC

Features:[1]

  • TTF-1 -ve.
  • Thyroglobulin -ve.
  • CK7 +ve/-ve.
  • PAX8 +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
  2. ↑ Ghaouti, M.; Roquet, L.; Baron, M.; Pfister, C.; Sabourin, JC. (2014). "Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature.". Diagn Pathol 9 (1): 186. doi:10.1186/s13000-014-0186-8. PMID 25293503.
  3. ↑ Wu, WW.; Chu, JT.; Nael, A.; Rezk, SA.; Romansky, SG.; Shane, L. (2014). "Thyroid-like follicular carcinoma of the kidney in a young patient with history of pediatric acute lymphoblastic leukemia.". Case Rep Pathol 2014: 313974. doi:10.1155/2014/313974. PMID 25133003.
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