Benign endometrial polyp: Difference between revisions
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| Grossing = | | Grossing = | ||
| Site = [[endometrium]] | | Site = [[endometrium]] | ||
| Assdx = [[invasive breast cancer]] - specifically assoc. with tamoxifen | | Assdx = [[invasive breast cancer]] - specifically assoc. with [[tamoxifen]] | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = bleeding ([[menorrhagia]]) | | Clinicalhx = bleeding ([[menorrhagia]]) | ||
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| ClinDDx = [[uterine leiomyoma|leiomyoma]], other polypoid masses | | ClinDDx = [[uterine leiomyoma|leiomyoma]], other polypoid masses | ||
}} | }} | ||
:''Uterine polyp'' | :''Uterine polyp'' and ''endometrial polyp'' redirect here. | ||
'''Benign endometrial polyp''', abbreviated '''BEP''', is a common diagnosis | '''Benign endometrial polyp''', abbreviated '''BEP''', is a common diagnosis in [[endometrium|endometrial]] specimens. | ||
It is also simply known as '''endometrial polyp''' which is a somewhat ambiguous descriptor as not all endometrial polyps are benign. | It is also simply known as '''endometrial polyp''' which is a somewhat ambiguous descriptor as not all endometrial polyps are benign. | ||
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*Very common. | *Very common. | ||
*May be a cause of [[menorrhagia]] (heavy & long menses). | *May be a cause of [[menorrhagia]] (heavy & long menses). | ||
*Malignant endometrial polyps are uncommon: <2% in one series of 965 cases.<ref name=pmid24820306>{{Cite journal | last1 = Tang | first1 = Z. | last2 = Zhou | first2 = R. | last3 = Bao | first3 = D. | last4 = Liu | first4 = C. | last5 = Wei | first5 = L. | title = [Clinical characteristics of 42 cases of malignant endometrial polyps]. | journal = Zhonghua Fu Chan Ke Za Zhi | volume = 49 | issue = 3 | pages = 204-7 | month = Mar | year = 2014 | doi = | PMID = 24820306 }}</ref> | |||
==Gross== | ==Gross== | ||
*Polypoid mass in the endometrial cavity. | *Polypoid mass in the endometrial cavity. | ||
Notes: | |||
*May be large - 10 cm.<ref name=pmid25093134>{{Cite journal | last1 = Unal | first1 = B. | last2 = Doğan | first2 = S. | last3 = Karaveli | first3 = FŞ. | last4 = Simşek | first4 = T. | last5 = Erdoğan | first5 = G. | last6 = Candaner | first6 = I. | title = Giant Endometrial Polyp in a Postmenopausal Woman without Hormone/Drug Use and Vaginal Bleeding. | journal = Case Rep Obstet Gynecol | volume = 2014 | issue = | pages = 518398 | month = | year = 2014 | doi = 10.1155/2014/518398 | PMID = 25093134 }}</ref> | |||
Gross DDx: | Gross DDx: | ||
*[[Secretory phase endometrium]].<ref name=pmid16873562/> | *[[Secretory phase endometrium]].<ref name=pmid16873562/> | ||
*Pedunculated [[uterine leiomyoma|leiomyoma]]. | *Pedunculated [[uterine leiomyoma|leiomyoma]]. | ||
==Microscopic== | ==Microscopic== | ||
Features - diagnostic criteria:<ref name=pmid16873562>{{Cite journal | last1 = McCluggage | first1 = WG. | title = My approach to the interpretation of endometrial biopsies and curettings. | journal = J Clin Pathol | volume = 59 | issue = 8 | pages = 801-12 | month = Aug | year = 2006 | doi = 10.1136/jcp.2005.029702 | PMID = 16873562 | PMC = 1860448 }}</ref> | Features - diagnostic criteria:<ref name=pmid16873562>{{Cite journal | last1 = McCluggage | first1 = WG. | title = My approach to the interpretation of endometrial biopsies and curettings. | journal = J Clin Pathol | volume = 59 | issue = 8 | pages = 801-12 | month = Aug | year = 2006 | doi = 10.1136/jcp.2005.029702 | PMID = 16873562 | PMC = 1860448 }}</ref> | ||
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Image: Nucleated red blood cells - endometrial polyp - low mag.jpg | Endometrial polyp - low mag. (WC) | Image: Nucleated red blood cells - endometrial polyp - low mag.jpg | Endometrial polyp - low mag. (WC) | ||
</gallery> | </gallery> | ||
==IHC== | |||
*p16 stroma usually +ve.<ref name=pmid>{{Cite journal | last1 = Moritani | first1 = S. | last2 = Ichihara | first2 = S. | last3 = Hasegawa | first3 = M. | last4 = Iwakoshi | first4 = A. | last5 = Murakami | first5 = S. | last6 = Sato | first6 = T. | last7 = Okamoto | first7 = T. | last8 = Mori | first8 = Y. | last9 = Kuhara | first9 = H. | title = Stromal p16 expression differentiates endometrial polyp from endometrial hyperplasia. | journal = Virchows Arch | volume = 461 | issue = 2 | pages = 141-8 | month = Aug | year = 2012 | doi = 10.1007/s00428-012-1276-1 | PMID = 22772724 }}</ref> | |||
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