Difference between revisions of "Transmembrane mucin 1"

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'''Transmembrane mucin 1''', commonly abbreviated '''MUC1''', is a commonly used [[immunostain]].
{{ Infobox stain
| Name      = {{PAGENAME}}
| Image      = EMA_dots_ependymoma.jpg
| Width      =
| Caption    = EMA staining in ependymoma.
| Abbrev    = MUC1, MUC-1, EMA
| Synonyms  = epithelial membrane antigen
| Similar    = pankeratin
| Clones    =     
| Use        =
| Subspecial = 
| Pattern    =
| Positive  = most [[adenocarcinoma]]s
| Negative  = [[basal cell carcinoma]]
| Other      =
}}
'''Transmembrane mucin 1''', commonly abbreviated '''MUC1''' (or '''MUC-1'''), is a commonly used [[immunostain]].


It is also known '''epithelial membrane antigen''', abbreviated '''EMA'''.
It is also known '''epithelial membrane antigen''', abbreviated '''EMA'''.<ref>{{OMIM|158340}}</ref>
 
A ring or dot-like expression pattern is typical for [[ependymoma]].<ref>{{Cite journal  | last1 = Hasselblatt | first1 = M. | last2 = Paulus | first2 = W. | title = Sensitivity and specificity of epithelial membrane antigen staining patterns in ependymomas. | journal = Acta Neuropathol | volume = 106 | issue = 4 | pages = 385-8 | month = Oct | year = 2003 | doi = 10.1007/s00401-003-0752-8 | PMID = 12898159 }}</ref>
 
===Images===
<gallery>
File:Miningioma (4) EMA.JPG | EMA staining in a [[meningioma]]. (WC/KGH)
File:EMA_dots_ependymoma.jpg | EMA staining in a ependymoma. (WC/jensflorian)
</gallery>


==See also==
==See also==
*[[Immunohistochemistry]].
*[[Immunohistochemistry]].
*[[AE1/AE3]].
*[[Z622]].
==References==
{{Reflist|1}}
==External links==
*[http://www.nordiqc.org/Epitopes/EMA/EMA.htm EMA (nordiqc.org)].


[[Category:Immunohistochemistry]]
[[Category:Immunohistochemistry]]

Latest revision as of 19:52, 4 January 2019

Transmembrane mucin 1
Stain in short

EMA staining in ependymoma.
Abbreviation MUC1, MUC-1, EMA
Synonyms epithelial membrane antigen
Similar stains pankeratin
Positive most adenocarcinomas
Negative basal cell carcinoma

Transmembrane mucin 1, commonly abbreviated MUC1 (or MUC-1), is a commonly used immunostain.

It is also known epithelial membrane antigen, abbreviated EMA.[1]

A ring or dot-like expression pattern is typical for ependymoma.[2]

Images

See also

References

  1. Online 'Mendelian Inheritance in Man' (OMIM) 158340
  2. Hasselblatt, M.; Paulus, W. (Oct 2003). "Sensitivity and specificity of epithelial membrane antigen staining patterns in ependymomas.". Acta Neuropathol 106 (4): 385-8. doi:10.1007/s00401-003-0752-8. PMID 12898159.

External links