Mantle cell lymphoma: Difference between revisions
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*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)]. | ||
[[File:4 718053471 sl 1.png|Mantle cell lymphoma]] | |||
[[File:4 718053471 sl 2.png|Mantle cell lymphoma]] | |||
[[File:4 718053471 sl 3.png|Mantle cell lymphoma]] | |||
[[File:4 718053471 sl 4.png|Mantle cell lymphoma]] | |||
[[File:4 718053471 sl 5.png|Mantle cell lymphoma]] | |||
[[File:4 718053471 sl 6.png|Mantle cell lymphoma]] | |||
[[File:4 718053471 sl 7.png|Mantle cell lymphoma]]<br> | |||
Mantle cell lymphoma in a 56 year old woman. A. A blue sea of cells spares a lymphoid follicle in the upper right corner. B. Small, round to reniform cells contrast with the larger tingible body macrophage (arrow). C-F. Tumor cells are Cyclin D1. CD20, BCL2, and CD5 positive positive. G. About 60% of tumor cells were positive for Ki67. Tumor cells were negative for CD3, CD10, and BCL6. | |||
==IHC== | ==IHC== | ||
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==Molecular== | ==Molecular== | ||
*t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | *t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | ||
==Sign out== | |||
<pre> | |||
TERMINAL ILEUM, BIOPSY: | |||
- MANTLE CELL LYMPHOMA. | |||
COMMENT: | |||
The tumour consists of small lymphoid cells in sheets. | |||
The tumour stains as follows: | |||
POSITIVE: CD20, CD5, BCL2, cyclin D1. | |||
NEGATIVE: CD23, BCL6, CD10. | |||
PROLIFERATION (Ki-67): 25%. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Small cell lymphomas]]. | *[[Small cell lymphomas]]. | ||
*[[Ileal nodular lymphoid hyperplasia]]. | |||
==References== | ==References== | ||