Difference between revisions of "Serous tubal intraepithelial carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Serous tubal intraepithelial carcinoma -- low mag.jpg | |||
| Width = | |||
| Caption = Micrograph showing serous tubal intraepithelial carcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = three of the following five: (1) atypical chromatin pattern, (2) nuclear enlargement, (3) nuclear pleomorphism, (4) nuclear moulding, (5) loss of nuclear polarity ''or'' epithelial stratification | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = p16 +ve, p53 +ve, Ki-67 increased | |||
| EM = | |||
| Molecular = BRCA1 mutation or BRCA2 mutation | |||
| IF = | |||
| Gross = not apparent on gross | |||
| Grossing = | |||
| Staging = | |||
| Site = [[fallopian tubes]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = none | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]]. | '''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]]. | ||
| Line 5: | Line 37: | ||
==General== | ==General== | ||
*Considered the precursor lesion for tubal [[serous carcinoma]].<ref name=pmid17117391>{{Cite journal | last1 = Lee | first1 = Y. | last2 = Miron | first2 = A. | last3 = Drapkin | first3 = R. | last4 = Nucci | first4 = MR. | last5 = Medeiros | first5 = F. | last6 = Saleemuddin | first6 = A. | last7 = Garber | first7 = J. | last8 = Birch | first8 = C. | last9 = Mou | first9 = H. | title = A candidate precursor to serous carcinoma that originates in the distal fallopian tube. | journal = J Pathol | volume = 211 | issue = 1 | pages = 26-35 | month = Jan | year = 2007 | doi = 10.1002/path.2091 | PMID = 17117391 }}</ref> | *Considered the precursor lesion for tubal [[serous carcinoma]].<ref name=pmid17117391>{{Cite journal | last1 = Lee | first1 = Y. | last2 = Miron | first2 = A. | last3 = Drapkin | first3 = R. | last4 = Nucci | first4 = MR. | last5 = Medeiros | first5 = F. | last6 = Saleemuddin | first6 = A. | last7 = Garber | first7 = J. | last8 = Birch | first8 = C. | last9 = Mou | first9 = H. | title = A candidate precursor to serous carcinoma that originates in the distal fallopian tube. | journal = J Pathol | volume = 211 | issue = 1 | pages = 26-35 | month = Jan | year = 2007 | doi = 10.1002/path.2091 | PMID = 17117391 }}</ref> | ||
*Seen in ~6% of prophylactic salpingo-oophorectomies in [[BRCA]]-mutation carriers.<ref name=pmid22710074>{{cite journal |author=Mingels MJ, Roelofsen T, van der Laak JA, ''et al.'' |title=Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls |journal=Gynecol. Oncol. |volume=127 |issue=1 |pages=88–93 |year=2012 |month=October |pmid=22710074 |doi=10.1016/j.ygyno.2012.06.015 |url=}}</ref> | |||
==Gross== | ==Gross== | ||
| Line 19: | Line 52: | ||
*#Nuclear moulding. | *#Nuclear moulding. | ||
*#Loss of nuclear polarity ''or'' epithelial stratification. | *#Loss of nuclear polarity ''or'' epithelial stratification. | ||
Notes: | |||
*At low power STIC is usually tall cells that are too blue. | |||
*Cilia suggest benign. | |||
DDx: | |||
*Atypical tubal lesion (STIL or ''tubal intraepithelial lesions in transition'' (TILT)<ref>{{cite journal |authors=Nishida N, Murakami F, Higaki K |title=Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer |journal=Pathol Int |volume=66 |issue=6 |pages=337–42 |date=June 2016 |pmid=27250113 |doi=10.1111/pin.12419 |url=}}</ref>) - lack proliferation.{{fact}} | |||
*[[Serous carcinoma of the fallopian tube]]. | |||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Serous tubal intraepithelial carcinoma -- extremely low mag.jpg | STIC - extremely low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma -- very low mag.jpg | STIC - very low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma -- low mag.jpg | STIC - low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma -- intermed mag.jpg | STIC - intermed. mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - alt -- intermed mag.jpg | STIC - intermed. mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma -- high mag.jpg | STIC - high mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - alt -- high mag.jpg | STIC - high mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma -- very high mag.jpg | STIC - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref> | *[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref> | ||
| Line 32: | Line 84: | ||
Features:<ref name=pmid21989347/> | Features:<ref name=pmid21989347/> | ||
*p53 +ve. | *p53 +ve. | ||
*Ki-67 | *Ki-67 increased ~10%. (???) | ||
*p16 +ve.<ref name=pmid20228782/> | *p16 +ve.<ref name=pmid20228782/> | ||
===Images=== | |||
<gallery> | |||
Image: Serous tubal intraepithelial carcinoma - p16 -- very low mag.jpg | STIC - p16 - very low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - p16 -- low mag.jpg | STIC - p16 - low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - p16 -- intermed mag.jpg | STIC - p16 - intermed. mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - p16 -- high mag.jpg | STIC - p16 - high mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - p53 -- very low mag.jpg | STIC - p53 - very low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - p53 -- low mag.jpg | STIC - p53 - low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - p53 -- intermed mag.jpg | STIC - p53 - intermed. mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - p53 -- high mag.jpg | STIC - p53 - high mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - Ki-67 -- very low mag.jpg | STIC - Ki-67 - very low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - Ki-67 -- low mag.jpg | STIC - Ki-67 - low mag. (WC) | |||
Image: Serous tubal intraepithelial carcinoma - Ki-67 -- high mag.jpg | STIC - Ki-67 - high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
Latest revision as of 05:17, 4 November 2024
| Serous tubal intraepithelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Micrograph showing serous tubal intraepithelial carcinoma. H&E stain. | |
|
| |
| LM | three of the following five: (1) atypical chromatin pattern, (2) nuclear enlargement, (3) nuclear pleomorphism, (4) nuclear moulding, (5) loss of nuclear polarity or epithelial stratification |
| IHC | p16 +ve, p53 +ve, Ki-67 increased |
| Molecular | BRCA1 mutation or BRCA2 mutation |
| Gross | not apparent on gross |
| Site | fallopian tubes |
|
| |
| Symptoms | none |
| Prevalence | uncommon |
Serous tubal intraepithelial carcinoma, abbreviated STIC[1] (pronounced stick), is considered to be the precursor of serous carcinoma.
It is also known as tubal intraepithelial carcinoma.
General
- Considered the precursor lesion for tubal serous carcinoma.[2]
- Seen in ~6% of prophylactic salpingo-oophorectomies in BRCA-mutation carriers.[3]
Gross
- Not apparent on gross.
- Usually at the fimbriated end of the tube.
Microscopic
Features:[4]
- Discrete papillary growth - low power.
- Formal criteria - need 3 or more:
- Atypical chromatin pattern.
- Nuclear enlargement.
- Nuclear pleomorphism.
- Nuclear moulding.
- Loss of nuclear polarity or epithelial stratification.
Notes:
- At low power STIC is usually tall cells that are too blue.
- Cilia suggest benign.
DDx:
- Atypical tubal lesion (STIL or tubal intraepithelial lesions in transition (TILT)[5]) - lack proliferation.[citation needed]
- Serous carcinoma of the fallopian tube.
Images
STIC - extremely low mag. (WC)
STIC - very low mag. (WC)
STIC - low mag. (WC)
STIC - intermed. mag. (WC)
STIC - intermed. mag. (WC)
STIC - high mag. (WC)
STIC - high mag. (WC)
STIC - very high mag. (WC)
www
- STIC (nature.com).[4]
- STIC - schematic (nih.gov).[6]
- STIC and STIL with p53 stain (nih.gov).[6]
- STIC - p53 stain (nih.gov).[6]
- Small STIC - H&E and p53 (nih.gov).[7]
- STIC - high mag. (ovariancancerprevention.org).[8]
- STIC & benign - high mag. (ovariancancerprevention.org).
IHC
Features:[1]
- p53 +ve.
- Ki-67 increased ~10%. (???)
- p16 +ve.[4]
Images
STIC - p16 - very low mag. (WC)
STIC - p16 - low mag. (WC)
STIC - p16 - intermed. mag. (WC)
STIC - p16 - high mag. (WC)
STIC - p53 - very low mag. (WC)
STIC - p53 - low mag. (WC)
STIC - p53 - intermed. mag. (WC)
STIC - p53 - high mag. (WC)
STIC - Ki-67 - very low mag. (WC)
STIC - Ki-67 - low mag. (WC)
STIC - Ki-67 - high mag. (WC)
See also
References
- ↑ 1.0 1.1 Visvanathan, K.; Vang, R.; Shaw, P.; Gross, A.; Soslow, R.; Parkash, V.; Shih, IeM.; Kurman, RJ. (Dec 2011). "Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study.". Am J Surg Pathol 35 (12): 1766-75. doi:10.1097/PAS.0b013e31822f58bc. PMID 21989347.
- ↑ Lee, Y.; Miron, A.; Drapkin, R.; Nucci, MR.; Medeiros, F.; Saleemuddin, A.; Garber, J.; Birch, C. et al. (Jan 2007). "A candidate precursor to serous carcinoma that originates in the distal fallopian tube.". J Pathol 211 (1): 26-35. doi:10.1002/path.2091. PMID 17117391.
- ↑ Mingels MJ, Roelofsen T, van der Laak JA, et al. (October 2012). "Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls". Gynecol. Oncol. 127 (1): 88–93. doi:10.1016/j.ygyno.2012.06.015. PMID 22710074.
- ↑ 4.0 4.1 4.2 Sehdev, AS.; Kurman, RJ.; Kuhn, E.; Shih, IeM. (Jun 2010). "Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.". Mod Pathol 23 (6): 844-55. doi:10.1038/modpathol.2010.60. PMID 20228782.
- ↑ Nishida N, Murakami F, Higaki K (June 2016). "Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer". Pathol Int 66 (6): 337–42. doi:10.1111/pin.12419. PMID 27250113.
- ↑ 6.0 6.1 6.2 Kurman, RJ.; Shih, IeM. (Jul 2011). "Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm.". Hum Pathol 42 (7): 918-31. doi:10.1016/j.humpath.2011.03.003. PMID 21683865.
- ↑ Gross, AL.; Kurman, RJ.; Vang, R.; Shih, IeM.; Visvanathan, K. (2010). "Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics.". J Oncol 2010: 126295. doi:10.1155/2010/126295. PMID 20445756.
- ↑ URL: http://www.ovariancancerprevention.org/?page_id=191. Accessed on: 13 May 2014.