Graft-versus-host disease: Difference between revisions
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Clinical: | Clinical: | ||
*May present as diarrhea. | *May present as diarrhea. | ||
*Main DDx (clinical): infection | *Main DDx (clinical): infection and certain drugs, especially mycophenolate | ||
==Microscopic== | ==Microscopic== | ||
| Line 38: | Line 38: | ||
Notes: | Notes: | ||
*Neutrophils | *Neutrophils may be present. | ||
DDx: | |||
* | *Drug effect (mycophenolate mofetil) - cannot be distinguished from GVHD. | ||
====Grading<ref name=pmid20953169/>==== | ====Grading<ref name=pmid20953169/>==== | ||
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===Microscopic (liver)=== | ===Microscopic (liver)=== | ||
:See: ''[[Vanishing bile duct syndrome]]''. | :See: ''[[Vanishing bile duct syndrome]]''. | ||
===Images=== | |||
<gallery> | |||
Image: apoptotic gastropathy intermed mag.jpg | Consistent with gastric GvHD (need to exclude mycophenolate as an alternative cause) - intermed mag. (WC) | |||
Image: apoptotic gastropathy high mag.jpg | Consistent with gastric GvHD - high mag. (WC) | |||
Image: Colonic graft-versus-host disease (high magnification).jpg | Colonic GvHD - high mag. (WC) | |||
Image: Skin graft versus host disease high mag 1.jpg | Skin GvHD - high mag. (WC) | |||
Image: Skin graft versus host disease high mag 1.jpg | Skin GvHD - high mag. (WC) | |||
</gallery> | |||
*[https://www.nature.com/articles/modpathol2010163/figures/1 GVHD grade 1-4 (nature.com)].<ref name=pmid20953169/> | |||
==See also== | ==See also== | ||