Difference between revisions of "Mesonephric remnant of the prostate gland"
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'''Mesonephric remnant | '''Mesonephric remnant of the prostate gland''', also '''mesonephric remnant''', is rare benign finding in the [[prostate gland]] that can be confused with [[prostate carcinoma]]. | ||
This article also deals with '''mesonephric remnant hyperplasia'''. | |||
==General== | ==General== | ||
*Very rare | *Very rare<ref name=pmid21606823>{{Cite journal | last1 = Chen | first1 = YB. | last2 = Fine | first2 = SW. | last3 = Epstein | first3 = JI. | title = Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy. | journal = Am J Surg Pathol | volume = 35 | issue = 7 | pages = 1054-61 | month = Jul | year = 2011 | doi = 10.1097/PAS.0b013e318218df97 | PMID = 21606823 }}</ref> ~ 0.6% incidence in a series of almost 700 [[TURP]] specimens.<ref name=pmid12861057>{{Cite journal | last1 = Bostwick | first1 = DG. | last2 = Qian | first2 = J. | last3 = Ma | first3 = J. | last4 = Muir | first4 = TE. | title = Mesonephric remnants of the prostate: incidence and histologic spectrum. | journal = Mod Pathol | volume = 16 | issue = 7 | pages = 630-5 | month = Jul | year = 2003 | doi = 10.1097/01.MP.0000074733.10777.78 | PMID = 12861057 }}</ref> | ||
*Can mimic prostate carcinoma.<ref name=pmid19917478>{{Cite journal | last1 = Yacoub | first1 = M. | last2 = Milin | first2 = S. | last3 = Irani | first3 = J. | last4 = Fromont | first4 = G. | title = Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancer. | journal = Ann Diagn Pathol | volume = 13 | issue = 6 | pages = 402-4 | month = Dec | year = 2009 | doi = 10.1016/j.anndiagpath.2009.03.008 | PMID = 19917478 }}</ref> | *Can mimic prostate carcinoma.<ref name=pmid19917478>{{Cite journal | last1 = Yacoub | first1 = M. | last2 = Milin | first2 = S. | last3 = Irani | first3 = J. | last4 = Fromont | first4 = G. | title = Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancer. | journal = Ann Diagn Pathol | volume = 13 | issue = 6 | pages = 402-4 | month = Dec | year = 2009 | doi = 10.1016/j.anndiagpath.2009.03.008 | PMID = 19917478 }}</ref> | ||
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**Scant-to-moderate cytoplasm.<ref name=pmid12861057/> | **Scant-to-moderate cytoplasm.<ref name=pmid12861057/> | ||
**Small/indistinct nucleoli. | **Small/indistinct nucleoli. | ||
Note: | |||
*May look like Gleason pattern 3 adenocarcinoma. | |||
DDx:<ref name=pmid21606823/> | DDx:<ref name=pmid21606823/> | ||
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==IHC== | ==IHC== | ||
Features:<ref name=pmid21606823/> | Features:<ref name=pmid21606823/> | ||
*PAX8 +ve. | *[[PAX8]] +ve. | ||
*PSA -ve (all). | *[[PSA]] -ve (all). | ||
*PSAP -ve.<ref name=pmid12861057 | *[[PSAP]] -ve.<ref name=pmid12861057/> | ||
*CK34betaE12 +ve/-ve (diffuse +ve in 4/7 cases) | *[[CK34betaE12]] +ve/-ve (diffuse +ve in 4/7 cases) | ||
*p63 -ve. | *[[p63]] -ve. | ||
*AMACR +ve (focal). | *[[AMACR]] +ve (focal). | ||
==See also== | ==See also== | ||
*[[Prostate gland]]. | *[[Prostate gland]]. | ||
*[[Prostate cancer]]. | *[[Prostate cancer]]. | ||
*[[Nephrogenic adenoma]]. | |||
==References== | ==References== | ||
Latest revision as of 14:52, 4 August 2022
Mesonephric remnant of the prostate gland, also mesonephric remnant, is rare benign finding in the prostate gland that can be confused with prostate carcinoma.
This article also deals with mesonephric remnant hyperplasia.
General
- Very rare[1] ~ 0.6% incidence in a series of almost 700 TURP specimens.[2]
- Can mimic prostate carcinoma.[3]
Microscopic
Features:[1]
- Small glands in a lobular arrangement composed of cuboidal cells with:
- Scant-to-moderate cytoplasm.[2]
- Small/indistinct nucleoli.
Note:
- May look like Gleason pattern 3 adenocarcinoma.
DDx:[1]
- Sclerosing adenosis of the prostate gland.
- Prostate carcinoma - esp. Gleason pattern 5.
Images
www:
IHC
Features:[1]
- PAX8 +ve.
- PSA -ve (all).
- PSAP -ve.[2]
- CK34betaE12 +ve/-ve (diffuse +ve in 4/7 cases)
- p63 -ve.
- AMACR +ve (focal).
See also
References
- ↑ 1.0 1.1 1.2 1.3 Chen, YB.; Fine, SW.; Epstein, JI. (Jul 2011). "Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.". Am J Surg Pathol 35 (7): 1054-61. doi:10.1097/PAS.0b013e318218df97. PMID 21606823.
- ↑ 2.0 2.1 2.2 2.3 Bostwick, DG.; Qian, J.; Ma, J.; Muir, TE. (Jul 2003). "Mesonephric remnants of the prostate: incidence and histologic spectrum.". Mod Pathol 16 (7): 630-5. doi:10.1097/01.MP.0000074733.10777.78. PMID 12861057.
- ↑ Yacoub, M.; Milin, S.; Irani, J.; Fromont, G. (Dec 2009). "Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancer.". Ann Diagn Pathol 13 (6): 402-4. doi:10.1016/j.anndiagpath.2009.03.008. PMID 19917478.