Difference between revisions of "Splenic hamartoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Splenic_hamartoma_-_very_low_mag.jpg
| Width      =
| Caption    = Splenic hamartoma. [[H&E stain]].
| Synonyms  =
| Micro      = variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles
| Subtypes  =
| LMDDx      = [[littoral cell angioma]]
| Stains    =
| IHC        = factor VIII +ve, CD31 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      = red, well-circumscribed
| Grossing  =
| Site      = [[spleen]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      = +/-splenic enlargement
| Symptoms  = +/-abdominal pain
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        = observe or splenectomy
}}
'''Splenic hamartoma''', also '''[[hamartoma]] of the spleen''', is an uncommon benign lesion of the [[spleen]].
'''Splenic hamartoma''', also '''[[hamartoma]] of the spleen''', is an uncommon benign lesion of the [[spleen]].


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*Benign.
*Benign.
*Women > men.<ref name=pmid21393931>{{Cite journal  | last1 = Sankar | first1 = S. | last2 = Thanka | first2 = J. | last3 = Jagdishchandrabose | first3 = S. | last4 = Rajendran | first4 = S. | title = Splenic hamartoma: a rare vascular space occupying lesion of the spleen. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 223-5 | month =  | year =  | doi = 10.4103/0377-4929.77416 | PMID = 21393931 }}</ref>
*Women > men.<ref name=pmid21393931>{{Cite journal  | last1 = Sankar | first1 = S. | last2 = Thanka | first2 = J. | last3 = Jagdishchandrabose | first3 = S. | last4 = Rajendran | first4 = S. | title = Splenic hamartoma: a rare vascular space occupying lesion of the spleen. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 223-5 | month =  | year =  | doi = 10.4103/0377-4929.77416 | PMID = 21393931 }}</ref>
*May cause pain.<ref>{{Cite journal  | last1 = Tatekawa | first1 = Y. | last2 = Kanehiro | first2 = H. | last3 = Nakajima | first3 = Y. | title = Laparoscopic extirpation of splenic hamartoma. | journal = Pediatr Surg Int | volume = 23 | issue = 9 | pages = 911-4 | month = Sep | year = 2007 | doi = 10.1007/s00383-007-1902-1 | PMID = 17364201 }}</ref>


==Gross==
==Gross==
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Image:Spleen_hamartom.jpg | Splenic hamartoma. (WC)
Image:Spleen_hamartom.jpg | Splenic hamartoma. (WC)
</gallery>
</gallery>
==Microscopic==
==Microscopic==
Features:<ref name=pmid19123729/>
Features:<ref name=pmid19123729/>
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*Red pulp-like disorganized stroma
*Red pulp-like disorganized stroma
*+/-Lymphoid follicles.  
*+/-Lymphoid follicles.  
DDx:
*[[Littoral cell angioma]].


===Images===
===Images===
<gallery>
<gallery>
Image:Splenic_hamartoma_-_very_low_mag.jpg | Splenic hamartoma - very low mag. (WC)
Image: Splenic hamartoma - very low mag.jpg | Splenic hamartoma - very low mag. (WC)
Image:Splenic_hamartoma_-_intermed_mag.jpg | Splenic hamartoma - intermed. mag. (WC)
Image: Splenic hamartoma - low mag.jpg | Splenic hamartoma - low mag. (WC)
Image:Splenic_hamartoma_-_very_high_mag.jpg | Splenic hamartoma - very high mag. (WC)
Image: Splenic hamartoma - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC)
Image: Splenic hamartoma - add - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC)
Image: Splenic hamartoma - high mag.jpg | Splenic hamartoma - high mag. (WC)
Image: Splenic hamartoma - very high mag.jpg | Splenic hamartoma - very high mag. (WC)
</gallery>
</gallery>


==IHC==
==IHC==
Features:<ref name=pmid19123729>{{Cite journal  | last1 = Lee | first1 = H. | last2 = Maeda | first2 = K. | title = Hamartoma of the spleen. | journal = Arch Pathol Lab Med | volume = 133 | issue = 1 | pages = 147-51 | month = Jan | year = 2009 | doi = 10.1043/1543-2165-133.1.147 | PMID = 19123729 }}
Features:
</ref>
*CD8 +ve endothelial cells.<ref name=pmid19123729>{{Cite journal  | last1 = Lee | first1 = H. | last2 = Maeda | first2 = K. | title = Hamartoma of the spleen. | journal = Arch Pathol Lab Med | volume = 133 | issue = 1 | pages = 147-51 | month = Jan | year = 2009 | doi = 10.1043/1543-2165-133.1.147 | PMID = 19123729 }}</ref>
*CD8 +ve endothelial cells.
*Factor VIII +ve (diffuse intense).<ref name=pmid15735864>{{Cite journal  | last1 = Ali | first1 = TZ. | last2 = Beyer | first2 = G. | last3 = Taylor | first3 = M. | last4 = Volpe | first4 = C. | last5 = Papadimitriou | first5 = JC. | title = Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases. | journal = Int J Surg Pathol | volume = 13 | issue = 1 | pages = 103-11 | month = Jan | year = 2005 | doi =  | PMID = 15735864 }}</ref>
**Background spleen -ve.
*CD31 -ve.<ref name=pmid15735864/>
**Background spleen +ve.


==See also==
==See also==

Latest revision as of 02:03, 9 April 2014

Splenic hamartoma
Diagnosis in short

Splenic hamartoma. H&E stain.
LM variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles
LM DDx littoral cell angioma
IHC factor VIII +ve, CD31 -ve
Gross red, well-circumscribed
Site spleen
Signs +/-splenic enlargement
Symptoms +/-abdominal pain
Prognosis benign
Treatment observe or splenectomy

Splenic hamartoma, also hamartoma of the spleen, is an uncommon benign lesion of the spleen.

General

  • Benign.
  • Women > men.[1]
  • May cause pain.[2]

Gross

  • Red lesion.
  • Well-circumscribed.

Image

  • Splenic hamartoma. (WC)

Microscopic

Features:[3]

  • Variable size irregular vascular channels
  • Red pulp-like disorganized stroma
  • +/-Lymphoid follicles.

DDx:

Images

  • Splenic hamartoma - very low mag. (WC)

  • Splenic hamartoma - low mag. (WC)

  • Splenic hamartoma - intermed. mag. (WC)

  • Splenic hamartoma - intermed. mag. (WC)

  • Splenic hamartoma - high mag. (WC)

  • Splenic hamartoma - very high mag. (WC)

IHC

Features:

  • CD8 +ve endothelial cells.[3]
  • Factor VIII +ve (diffuse intense).[4]
    • Background spleen -ve.
  • CD31 -ve.[4]
    • Background spleen +ve.

See also

References

  1. ↑ Sankar, S.; Thanka, J.; Jagdishchandrabose, S.; Rajendran, S.. "Splenic hamartoma: a rare vascular space occupying lesion of the spleen.". Indian J Pathol Microbiol 54 (1): 223-5. doi:10.4103/0377-4929.77416. PMID 21393931.
  2. ↑ Tatekawa, Y.; Kanehiro, H.; Nakajima, Y. (Sep 2007). "Laparoscopic extirpation of splenic hamartoma.". Pediatr Surg Int 23 (9): 911-4. doi:10.1007/s00383-007-1902-1. PMID 17364201.
  3. ↑ 3.0 3.1 Lee, H.; Maeda, K. (Jan 2009). "Hamartoma of the spleen.". Arch Pathol Lab Med 133 (1): 147-51. doi:10.1043/1543-2165-133.1.147. PMID 19123729.
  4. ↑ 4.0 4.1 Ali, TZ.; Beyer, G.; Taylor, M.; Volpe, C.; Papadimitriou, JC. (Jan 2005). "Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases.". Int J Surg Pathol 13 (1): 103-11. PMID 15735864.
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