Solid pseudopapillary tumour: Difference between revisions
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'''Solid pseudopapillary tumour''' is a pancreatic tumour that is usually found in the tail. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Solid_pseudopapillary_tumour_-_high_mag.jpg | |||
| Width = | |||
| Caption = Solid pseudopapillary tumour. [[H&E stain]]. | |||
| Synonyms = solid pseudopapillary neoplasm, solid and papillary epithelial neoplasm | |||
| Micro = solid sheets of cells - focally dyscohesive, eosinophilic cytoplasm (occasionally clear), focal eosinophilic (intracytoplasmic) globules, uniform nuclei with occasional nuclear grooves, +/-necrosis (creating spaces/cavities), +/-cholesterol clefts | |||
| Subtypes = | |||
| LMDDx = [[pancreatic pseudocyst]], cystadenoma, cystadenocarcinoma (see [[invasive ductal carcinoma of the pancreas]]), [[pancreatic neuroendocrine tumour]] | |||
| Stains = | |||
| IHC = PR +ve, CD10 +ve, beta-catenin +ve, chromogranin -ve, synaptophysin +ve (weak) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[pancreas]] - usually tail | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = typical young (20s or 30s), women (M:F = 1:9) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usu. benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Solid pseudopapillary tumour''' is a [[pancreas|pancreatic]] tumour that is usually found in the tail. | |||
It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref> | It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref> | ||
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www: | www: | ||
*[http://jcp.bmj.com/content/61/11/1153/F1.large.jpg Solid pseudopapillary tumour (bmj.com)]. | *[http://jcp.bmj.com/content/61/11/1153/F1.large.jpg Solid pseudopapillary tumour (bmj.com)]. | ||
[[File: PANC solid pseudo 1 sl 1.png| Solid-pseudopapillary neoplasm of pancreas]] | |||
[[File: PANC solid pseudo 1 sl 2.png| Solid-pseudopapillary neoplasm of pancreas]] | |||
[[File: PANC solid pseudo 1 sl 3.png| Solid-pseudopapillary neoplasm of pancreas]] | |||
[[File: PANC solid pseudo 1 sl 4.png| Solid-pseudopapillary neoplasm of pancreas]] | |||
[[File: PANC solid pseudo 1 sl 5.png| Solid-pseudopapillary neoplasm of pancreas]] | |||
[[File: PANC solid pseudo 1 sl 6.png| Solid-pseudopapillary neoplasm of pancreas]] | |||
Solid-pseudopapillary neoplasm of pancreas. A. Tumor with prominent blood vessels and small cyst like spaces contrasts with normal pancreatic acini at right. B. Cohesive cell population. C. More dishesive cell population. D. Vascular pseudopapillae with hyalinized stroma. E. Aggregates of variably sized hyaline globules. Arrow points to longitudinal nuclear groove. F. Sometimes, as here, the cells show varied nuclear sizes and shapes. The cytoplasm, lightly eosinophilic to cleared, can have vacuoles (arrows). | |||
==IHC== | ==IHC== | ||
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Others: | Others: | ||
*CD56 +ve. | *[[CD56]] +ve. | ||
*Chromogranin -ve. | *Chromogranin -ve. | ||