Paget's disease of the bone: Difference between revisions
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref> | Features:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref> | ||
*Lytic and mixed Paget disease are cellular and fibro-osseous (bone and fibrous components) | |||
*Sclerotic Paget disease has thickened bone trabeculae. | |||
*Bone matrix has jigsaw-puzzle like pattern. | *Bone matrix has jigsaw-puzzle like pattern. | ||
**Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | **Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | ||
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Image:Paget_disease_of_bone_-_high_mag.jpg | Paget's disease - bone - high mag. (WC/Nephron) | Image:Paget_disease_of_bone_-_high_mag.jpg | Paget's disease - bone - high mag. (WC/Nephron) | ||
Image:Paget_disease_of_bone_-_very_high_mag.jpg | Paget's disease - bone - very high mag. (WC/Nephron) | Image:Paget_disease_of_bone_-_very_high_mag.jpg | Paget's disease - bone - very high mag. (WC/Nephron) | ||
Image:Bone PagetDisease MP2 PA (2).JPG|Early Paget disease - cellular fibro-osseous lesion osteoclastic resorptive lacunae.(SKB) | |||
Image:Bone PagetDisease MP2 PA.JPG|Early Paget disease - Cellular fibro-osseous lesions with less calcified osteoid trabeculae exhibiting some osteoblastic rimming. (SKB) | |||
</gallery> | </gallery> | ||