Ameloblastoma: Difference between revisions
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'''Ameloblastoma''' is an [[odontogenic | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Ameloblastoma - high mag.jpg | |||
| Width = | |||
| Caption = Ameloblastoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = stellate reticulum (star-shaped cells), tall columnar cells that have palisaded nuclei with reverse polarization, subnuclear vacuolization, +/-giant cells, +/-subepithelial hyalinization (eosinophilic acellular amorphous material) | |||
| Subtypes = solid/multicystic, unicystic | |||
| LMDDx = [[adenomatoid odontogenic tumour]], [[ameloblastic fibroma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = usu. mandible - see ''[[odontogenic tumours and cysts]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = locally aggresive, rarely malignant | |||
| Other = | |||
| ClinDDx = [[keratocystic odontogenic tumour]], odontogenic cysts | |||
| Tx = | |||
}} | |||
'''Ameloblastoma''' is an [[odontogenic tumour]]. | |||
==General== | ==General== | ||
*Osteous lesion. | *Osteous lesion. | ||
*Usually mandible.<ref>URL: [http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm]. Accessed on: 30 November 2011.</ref> | *Usually mandible.<ref>URL: [http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm]. Accessed on: 30 November 2011.</ref> | ||
**In a review of 3677 cases, the mandible-to-maxilla ratio was 5 to 1.<ref name=pmid7633291>{{Cite journal | last1 = Reichart | first1 = PA. | last2 = Philipsen | first2 = HP. | last3 = Sonner | first3 = S. | title = Ameloblastoma: biological profile of 3677 cases. | journal = Eur J Cancer B Oral Oncol | volume = 31B | issue = 2 | pages = 86-99 | month = Mar | year = 1995 | doi = | PMID = 7633291 }}</ref> | **In a review of 3677 cases, the mandible-to-[[maxilla]] ratio was 5 to 1.<ref name=pmid7633291>{{Cite journal | last1 = Reichart | first1 = PA. | last2 = Philipsen | first2 = HP. | last3 = Sonner | first3 = S. | title = Ameloblastoma: biological profile of 3677 cases. | journal = Eur J Cancer B Oral Oncol | volume = 31B | issue = 2 | pages = 86-99 | month = Mar | year = 1995 | doi = | PMID = 7633291 }}</ref> | ||
*May arise from an odontogenic cyst,<ref name=pmid10587275>{{Cite journal | last1 = Eversole | first1 = LR. | title = Malignant epithelial odontogenic tumors. | journal = Semin Diagn Pathol | volume = 16 | issue = 4 | pages = 317-24 | month = Nov | year = 1999 | doi = | PMID = 10587275 }}</ref> e.g. [[dentigerous cyst]].<ref name=pmid21957386>{{Cite journal | last1 = Moosvi | first1 = Z. | last2 = Tayaar | first2 = SA. | last3 = Kumar | first3 = GS. | title = Neoplastic potential of odontogenic cysts. | journal = Contemp Clin Dent | volume = 2 | issue = 2 | pages = 106-9 | month = Apr | year = 2011 | doi = 10.4103/0976-237X.83073 | PMID = 21957386 | PMC = 3180832 }}</ref> | *May arise from an odontogenic cyst,<ref name=pmid10587275>{{Cite journal | last1 = Eversole | first1 = LR. | title = Malignant epithelial odontogenic tumors. | journal = Semin Diagn Pathol | volume = 16 | issue = 4 | pages = 317-24 | month = Nov | year = 1999 | doi = | PMID = 10587275 }}</ref> e.g. [[dentigerous cyst]].<ref name=pmid21957386>{{Cite journal | last1 = Moosvi | first1 = Z. | last2 = Tayaar | first2 = SA. | last3 = Kumar | first3 = GS. | title = Neoplastic potential of odontogenic cysts. | journal = Contemp Clin Dent | volume = 2 | issue = 2 | pages = 106-9 | month = Apr | year = 2011 | doi = 10.4103/0976-237X.83073 | PMID = 21957386 | PMC = 3180832 }}</ref> | ||
*Can be malignant<ref name=pmid15454770>{{Cite journal | last1 = Goldenberg | first1 = D. | last2 = Sciubba | first2 = J. | last3 = Koch | first3 = W. | last4 = Tufano | first4 = RP. | title = Malignant odontogenic tumors: a 22-year experience. | journal = Laryngoscope | volume = 114 | issue = 10 | pages = 1770-4 | month = Oct | year = 2004 | doi = 10.1097/00005537-200410000-00018 | PMID = 15454770 }}</ref> - rare.<ref name=pmid23775022>{{Cite journal | last1 = Chou | first1 = YH. | last2 = Jhuang | first2 = JY. | last3 = Chang | first3 = MH. | last4 = Huang | first4 = WC. | last5 = Hsieh | first5 = MS. | title = Metastasizing Ameloblastoma With Localized Interstitial Spread in the Lung: Report of Two Cases. | journal = Int J Surg Pathol | volume = | issue = | pages = | month = Jun | year = 2013 | doi = 10.1177/1066896913491321 | PMID = 23775022 }}</ref> | |||
===Classification=== | ===Classification=== | ||
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#*Unlikely to reoccur. | #*Unlikely to reoccur. | ||
#*Classically found in younger individuals. | #*Classically found in younger individuals. | ||
==Gross== | |||
*Mass - usu. mandible or maxilla.<ref name=pmid23775022/> | |||
**Mandile most common. | |||
==Microscopic== | ==Microscopic== | ||
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===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||