Paneth cell: Difference between revisions
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[[Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | thumb | right |Paneth cell metaplasia. [[H&E stain]].]] | [[Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | thumb | right |Paneth cell metaplasia and lamina propria [[eosinophil]]s. [[H&E stain]]. ]] | ||
The '''Paneth cell''' is characteristic of the [[small intestine]]. It is also normal in the [[cecum]], ascending colon and transverse colon. | The '''Paneth cell''' is characteristic of the [[small intestine]]. It is also normal in the [[cecum]], ascending colon and transverse colon. | ||
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If PCM is present: | If PCM is present: | ||
*Think of [[inflammatory bowel disease]] and other long-standing injurious processes. | *Think of [[inflammatory bowel disease]] and other long-standing injurious processes. | ||
*PCM in the context of colorectal adenomas may be associated with a higher risk of colorectal neoplasia.<ref name=pmid23232853>{{Cite journal | last1 = Pai | first1 = RK. | last2 = Rybicki | first2 = LA. | last3 = Goldblum | first3 = JR. | last4 = Shen | first4 = B. | last5 = Xiao | first5 = SY. | last6 = Liu | first6 = X. | title = Paneth cells in colonic adenomas: association with male sex and adenoma burden. | journal = Am J Surg Pathol | volume = 37 | issue = 1 | pages = 98-103 | month = Jan | year = 2013 | doi = 10.1097/PAS.0b013e318267b02e | PMID = 23232853 }}</ref> | |||
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==Microscopic== | ==Microscopic== | ||
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Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | PCM - extremely high mag. (WC) | Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | PCM - extremely high mag. (WC) | ||
</gallery> | </gallery> | ||
==IHC== | |||
*Lysozyme +ve.<ref name=pmid12655793>{{cite journal |author=Rubio CA, Nesi G |title=A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections |journal=In Vivo |volume=17 |issue=1 |pages=67–71 |year=2003 |pmid=12655793 |doi= |url=}}</ref> | |||
==See also== | ==See also== | ||
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*[[Inflammatory bowel disease]]. | *[[Inflammatory bowel disease]]. | ||
*[[Colon]]. | *[[Colon]]. | ||
*[[Paneth cell-like change of the prostate gland]]. | |||
==References== | ==References== | ||