Talk:Neuropathology tumours: Difference between revisions

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==Meningioma==
==Meningioma==
===Microscopic===
See: ''[[Talk:Meningioma]]''.
The microscopic '''section/sections''' show'''s''' a moderately cellular with lesion with prominent whorls, thick-walled blood vessels and focal psammomatous calcifications.
 
There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2.  There are no macronucleoli, no sheeting architecture, no hypercellularity, no lymphocyte-like change, and no spontaneous necrosis.  No brain tissue is present.
 
===Final diagnosis===
MENINGIOMA, GRADE 1.


==Anaplastic astrocytoma==
==Anaplastic astrocytoma==
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The sections show a partially cystic vascular tumour with histomorphological normal endothelial cells and vacuolated polygonal cells with hyperchromatic nuclei.  There is no mitotic activity.  The tumour has a poorly demarcated border.  Cerebellum adjacent to the tumour demonstrates Purkinje cell loss and Bergmann gliosis.
The sections show a partially cystic vascular tumour with histomorphological normal endothelial cells and vacuolated polygonal cells with hyperchromatic nuclei.  There is no mitotic activity.  The tumour has a poorly demarcated border.  Cerebellum adjacent to the tumour demonstrates Purkinje cell loss and Bergmann gliosis.


Immunohistochemical staining shows that the tumour is positive focally and weakly for inhibin and is strongly positive for neuron-specific enolase (NSE).  
The large polygonal cells have cytoplasmic staining with alpha-inhibin and neuron-specific enolase (NSE). The tumour does not stain for EMA.
 


===Final diagnosis===
===Final diagnosis===
BRAIN, CEREBELLUM, EXCISION:   
BRAIN, CEREBELLUM, EXCISION:   
<br> - HEMANGIOBLASTOMA.
<br> - HEMANGIOBLASTOMA (WHO GRADE I).
 


==Metastatic large cell carcinoma==
==Metastatic large cell carcinoma==
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BRAIN, CEREBELLUM:
BRAIN, CEREBELLUM:
<br>-METASTATIC LARGE CELL ADENOCARCINOMA.
<br>-METASTATIC LARGE CELL ADENOCARCINOMA.
== Neuroma ==
===Microscopic===
The section shows a medium-sized nerve with adjacent small organized micro-fascicles in collagen, consistent with nerve regeneration following injury. 
===Diagnosis===
NERVE, LEFT RADIAL:
<Br>- TRAUMATIC NEUROMA.
== Chordoma ==
===Microscopic description===
The sections show a tumour composed of irregular anatoming cords of physaliferous cells resting on a myxoid background.  Mitotic activity is not detected.
Immunostains demonstrate that the tumour cells intensely express cytoplasmic for low molecular weight keratin (LMWCK) and membranous epithelial membrane antigen (EMA).  There is weak, focal cytoplasmic expression of S100.
===Final diagnosis===
CLIVUS:
<br>- CHORDOMA.
== Pilocytic astrocytoma ==
===Microscopic description===
The smear shows bipolar cells with thick hair-like processes.  The sections show a cellular tumour with eosinophilic cytoplasm drawn into processes.  Eosinophilic granular bodies and Rosenthal fibres are present, as demonstrated with trichrome staining.
There is no nuclear pleomorphism and no mitotic activity.  There is no microvascular proliferation and no necrosis.
===Final diagnosis===
BRAIN:<br>
- PILOCYTIC ASTROCYTOMA (WHO GRADE I).
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