Difference between revisions of "Pigmented spindle cell nevus"
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| Caption = Pigmented spindle cell nevus. [[H&E stain]]. | | Caption = Pigmented spindle cell nevus. [[H&E stain]]. | ||
| Synonyms = Pigmented spindle cell nevus of Reed, Reed nevus | |||
| Micro = nests of heavily pigmented spindle cells at dermal-epidermal junction, no epithelioid cells | | Micro = nests of heavily pigmented spindle cells at dermal-epidermal junction, no epithelioid cells | ||
| Subtypes = | | Subtypes = | ||
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = dark brown/back, usu. 3-6 mm | ||
| Grossing = | | Grossing = | ||
| Site = [[skin]] - usu. lower extremity, back, shoulder | | Site = [[skin]] - usu. lower extremity, back, shoulder | ||
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| Other = | | Other = | ||
| ClinDDx = other [[melanocytic lesions]] | | ClinDDx = other [[melanocytic lesions]] | ||
| Tx = | |||
}} | }} | ||
'''Pigmented spindle cell nevus''', also '''pigmented spindle cell nevus of Reed''', is an uncommon benign [[melanocytic lesion]]. | '''Pigmented spindle cell nevus''', also '''pigmented spindle cell nevus of Reed''' and '''Reed nevus''',<ref name=pmid21997694/> is an uncommon benign [[melanocytic lesion]]. | ||
==General== | ==General== | ||
*Benign. | |||
*Uncommon. | *Uncommon. | ||
*Women<ref name=pmid8463457/> | *Women (M:F = 1:1.4<ref name=pmid8463457/>). | ||
*Usually 20s or teens. | |||
Note: | |||
*It was previously considered a variant of [[Spitz nevus]].<ref name=pmid21605093>{{cite journal |author=Webber SA, Siller G, Soyer HP |title=Pigmented spindle cell naevus of Reed: a controversial diagnostic entity in Australia |journal=Australas. J. Dermatol. |volume=52 |issue=2 |pages=104–8 |year=2011 |month=May |pmid=21605093 |doi=10.1111/j.1440-0960.2011.00743.x |url=}}</ref> | |||
==Gross== | ==Gross== | ||
Features:<ref name=pmid8463457>{{Cite journal | last1 = Sau | first1 = P. | last2 = Graham | first2 = JH. | last3 = Helwig | first3 = EB. | title = Pigmented spindle cell nevus: a clinicopathologic analysis of ninety-five cases. | journal = J Am Acad Dermatol | volume = 28 | issue = 4 | pages = 565-71 | month = Apr | year = 1993 | doi = | PMID = 8463457 }}</ref> | Features:<ref name=pmid8463457>{{Cite journal | last1 = Sau | first1 = P. | last2 = Graham | first2 = JH. | last3 = Helwig | first3 = EB. | title = Pigmented spindle cell nevus: a clinicopathologic analysis of ninety-five cases. | journal = J Am Acad Dermatol | volume = 28 | issue = 4 | pages = 565-71 | month = Apr | year = 1993 | doi = | PMID = 8463457 }}</ref> | ||
| Line 69: | Line 75: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid21997694>{{Cite journal | last1 = Díaz | first1 = A. | last2 = Valera | first2 = A. | last3 = Carrera | first3 = C. | last4 = Hakim | first4 = S. | last5 = Aguilera | first5 = P. | last6 = García | first6 = A. | last7 = Palou | first7 = J. | last8 = Puig | first8 = S. | last9 = Malvehy | first9 = J. | title = Pigmented spindle cell nevus: clues for differentiating it from spindle cell malignant melanoma. A comprehensive survey including clinicopathologic, immunohistochemical, and FISH studies. | journal = Am J Surg Pathol | volume = 35 | issue = 11 | pages = 1733-42 | month = Nov | year = 2011 | doi = 10.1097/PAS.0b013e318229cf66 | PMID = 21997694 }}</ref> | Features:<ref name=pmid21997694>{{Cite journal | last1 = Díaz | first1 = A. | last2 = Valera | first2 = A. | last3 = Carrera | first3 = C. | last4 = Hakim | first4 = S. | last5 = Aguilera | first5 = P. | last6 = García | first6 = A. | last7 = Palou | first7 = J. | last8 = Puig | first8 = S. | last9 = Malvehy | first9 = J. | title = Pigmented spindle cell nevus: clues for differentiating it from spindle cell malignant melanoma. A comprehensive survey including clinicopathologic, immunohistochemical, and FISH studies. | journal = Am J Surg Pathol | volume = 35 | issue = 11 | pages = 1733-42 | month = Nov | year = 2011 | doi = 10.1097/PAS.0b013e318229cf66 | PMID = 21997694 }}</ref> | ||
*Cyclin D1 ~12% of cells (range 1-40%) vs. ~42% of cells (range 1-95%). | *Cyclin D1 ~12% of cells (range 1-40%) vs. ~42% of cells (range 1-95%) in melanoma. | ||
*Ki-67 ~1% of cells (range 0-5%) vs. ~13% (range 1-40%). | *Ki-67 ~1% of cells (range 0-5%) vs. ~13% (range 1-40%) in melanoma. | ||
==Sign out== | ==Sign out== | ||
Latest revision as of 23:50, 25 June 2014
| Pigmented spindle cell nevus | |
|---|---|
| Diagnosis in short | |
 Pigmented spindle cell nevus. H&E stain. | |
|
| |
| Synonyms | Pigmented spindle cell nevus of Reed, Reed nevus |
|
| |
| LM | nests of heavily pigmented spindle cells at dermal-epidermal junction, no epithelioid cells |
| LM DDx | malignant melanoma, Spitz nevus |
| Gross | dark brown/back, usu. 3-6 mm |
| Site | skin - usu. lower extremity, back, shoulder |
|
| |
| Clinical history | classically women - teens and 20s |
| Prevalence | uncommon |
| Prognosis | good |
| Clin. DDx | other melanocytic lesions |
Pigmented spindle cell nevus, also pigmented spindle cell nevus of Reed and Reed nevus,[1] is an uncommon benign melanocytic lesion.
General
- Benign.
- Uncommon.
- Women (M:F = 1:1.4[2]).
- Usually 20s or teens.
Note:
- It was previously considered a variant of Spitz nevus.[3]
Gross
Features:[2]
- Dark brown/black.
- Typically 3-6 mm.
- Mostly under 7 mm.[1]
Location:
- Usually extremities (75% in one series[2]) - typically lower extremities.
- Back.
- Shoulder region.
Microscopic
Features:[4]
- Nests of heavily pigmented spindle cells at dermal-epidermal junction - key feature.
- Nevoid cells in epidermis & dermis - form "basket weave" pattern.
- Well-circumscribed lesion.
Notes:
- No epithelioid nevus cells.
DDx:
Images
PSCN - low mag. (WC)
PSCN - intermed. mag. (WC)
PSCN - high mag. (WC)
www:
IHC
Features:[1]
- Cyclin D1 ~12% of cells (range 1-40%) vs. ~42% of cells (range 1-95%) in melanoma.
- Ki-67 ~1% of cells (range 0-5%) vs. ~13% (range 1-40%) in melanoma.
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SKIN LESION, RIGHT POSTERIOR NECK, EXCISION: - PIGMENTED SPINDLE CELL NEVUS OF REED. -- COMPLETELY EXCISED (CLEARANCE ~ 1 MM).
Micro
The sections show spindled pigmented melanocytes in nests confined to the epidermis. The lesion is symmetrical in its architecture and pigment distribution. There is no pagetoid spread of melanocytes in the epidermis. No significant nuclear atypia is identified. No mitotic activity is appreciated. Melanophages are present in the superficial dermis. The lesion is completely excised in the plane of section.
See also
References
- ↑ 1.0 1.1 1.2 Díaz, A.; Valera, A.; Carrera, C.; Hakim, S.; Aguilera, P.; García, A.; Palou, J.; Puig, S. et al. (Nov 2011). "Pigmented spindle cell nevus: clues for differentiating it from spindle cell malignant melanoma. A comprehensive survey including clinicopathologic, immunohistochemical, and FISH studies.". Am J Surg Pathol 35 (11): 1733-42. doi:10.1097/PAS.0b013e318229cf66. PMID 21997694.
- ↑ 2.0 2.1 2.2 Sau, P.; Graham, JH.; Helwig, EB. (Apr 1993). "Pigmented spindle cell nevus: a clinicopathologic analysis of ninety-five cases.". J Am Acad Dermatol 28 (4): 565-71. PMID 8463457.
- ↑ Webber SA, Siller G, Soyer HP (May 2011). "Pigmented spindle cell naevus of Reed: a controversial diagnostic entity in Australia". Australas. J. Dermatol. 52 (2): 104–8. doi:10.1111/j.1440-0960.2011.00743.x. PMID 21605093.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 500. ISBN 978-0781765275.