Sinus histiocytosis: Difference between revisions
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| Caption = Sinus histiocytosis. [[H&E stain]]. | | Caption = Sinus histiocytosis. [[H&E stain]]. | ||
| Micro = | | Micro = sinuses distended with histiocytes without atypia | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[Rosai-Dorfman disease]], [[dermatopathic lymphadenopathy]], [[lymph node metastasis]] | | LMDDx = [[Rosai-Dorfman disease]], [[dermatopathic lymphadenopathy]], [[lymph node metastasis]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = CD68 +ve, S-100 -ve, pankeratin -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = variable | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
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Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref> | Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref> | ||
*Sinuses distended with histiocytes - '''key feature'''. | *Sinuses distended with histiocytes - '''key feature'''. | ||
**Histocytes: abundant foamy cytoplasm, +/- | **Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]] and/or [[yellow bodies]]. | ||
*[[Plasma cell]]s increased. | *[[Plasma cell]]s increased. | ||
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*[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus. | *[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus. | ||
*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment. | *[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment. | ||
*[[Lymph node metastasis]] - usually not difficult if one compares | *[[Lymph node metastasis]] - usually not difficult to exclude, esp. if one compares the germinal center macrophages and the primary tumour. | ||
===Images=== | ===Images=== | ||