Difference between revisions of "Sinus histiocytosis"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Sinus histiocytosis -- intermed mag.jpg
| Width      =
| Caption    = Sinus histiocytosis. [[H&E stain]].
| Micro      = sinuses distended with histiocytes without atypia
| Subtypes  =
| LMDDx      = [[Rosai-Dorfman disease]], [[dermatopathic lymphadenopathy]], [[lymph node metastasis]]
| Stains    =
| IHC        = CD68 +ve, S-100 -ve, pankeratin -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[lymph node]] - see ''[[lymph node pathology]]''
| Assdx      =
| Syndromes  =
| Clinicalhx = variable
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = other causes of lymphadenopathy esp. [[lymphoma]], [[lymph node metastasis]]
}}
'''Sinus histiocytosis''', abbreviated '''SH''', is a common finding in [[lymph nodes]].   
'''Sinus histiocytosis''', abbreviated '''SH''', is a common finding in [[lymph nodes]].   


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Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref>
Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref>
*Sinuses distended with histiocytes - '''key feature'''.
*Sinuses distended with histiocytes - '''key feature'''.
**Histocytes: abundant foamy cytoplasm, +/-anthrocotic pigment.
**Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]] and/or [[yellow bodies]].
*[[Plasma cell]]s increased.
*[[Plasma cell]]s increased.


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*[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus.
*[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus.
*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.
*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.
*[[Lymph node metastasis]] - usually not difficult if one compares with the germinal center macrophages and the primary tumour.
*[[Lymph node metastasis]] - usually not difficult to exclude, esp. if one compares the germinal center macrophages and the primary tumour.


===Images===
===Images===
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*CD68 +ve.
*CD68 +ve.
*S-100 -ve.
*S-100 -ve.
*Pankeratin -ve.
**Used to excluded metastatic carcinoma.


==Sign out==
==Sign out==

Latest revision as of 03:50, 22 October 2014

Sinus histiocytosis
Diagnosis in short

Sinus histiocytosis. H&E stain.

LM sinuses distended with histiocytes without atypia
LM DDx Rosai-Dorfman disease, dermatopathic lymphadenopathy, lymph node metastasis
IHC CD68 +ve, S-100 -ve, pankeratin -ve
Site lymph node - see lymph node pathology

Clinical history variable
Prevalence common
Prognosis benign
Clin. DDx other causes of lymphadenopathy esp. lymphoma, lymph node metastasis

Sinus histiocytosis, abbreviated SH, is a common finding in lymph nodes.

It should not be confused with Rosai-Dorfman disease (also known as sinus histiocytosis and massive lymphadenopathy).

General

  • Benign.
  • Non-specific finding.
  • Frequently associated with infections and neoplasia.[1]
  • Reported in association with hip replacements.[2]

Gross

  • +/-Enlargement of lymph node.[3]

Microscopic

Features:[4]

DDx:

Images

IHC

  • CD68 +ve.
  • S-100 -ve.
  • Pankeratin -ve.
    • Used to excluded metastatic carcinoma.

Sign out

  • The finding is often ignored; may be signed out as morphologically benign lymph nodes.

See also

References

  1. Hartmann, S.; Kriener, S.; Hansmann, ML. (Jul 2008). "[Diagnostic spectrum of reactive lymph node changes].". Pathologe 29 (4): 253-63. doi:10.1007/s00292-008-1003-5. PMID 18504582.
  2. Albores-Saavedra, J.; Vuitch, F.; Delgado, R.; Wiley, E.; Hagler, H. (Jan 1994). "Sinus histiocytosis of pelvic lymph nodes after hip replacement. A histiocytic proliferation induced by cobalt-chromium and titanium.". Am J Surg Pathol 18 (1): 83-90. PMID 8279630.
  3. Saito, T.; Kuwahara, A.; Kaketani, K.; Hirao, E.; Miyahara, M.; Shimoda, K.; Kobayashi, M. (Mar 1991). "Preoperative assessment of cervical lymph node involvement in esophageal cancer.". Jpn J Surg 21 (2): 145-53. PMID 2051659.
  4. Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 179. ISBN 978-0781775960.