Difference between revisions of "Pulmonary blastoma"
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'''Pulmonary blastoma''' is a very rare tumour of the [[lung]]. These tumours are often lumped into the ''pulmonary sarcomatoid carcinomas'' group.<ref name=pmid19124452>{{Cite journal | last1 = Pelosi | first1 = G. | last2 = Sonzogni | first2 = A. | last3 = De Pas | first3 = T. | last4 = Galetta | first4 = D. | last5 = Veronesi | first5 = G. | last6 = Spaggiari | first6 = L. | last7 = Manzotti | first7 = M. | last8 = Fumagalli | first8 = C. | last9 = Bresaola | first9 = E. | title = Review article: pulmonary sarcomatoid carcinomas: a practical overview. | journal = Int J Surg Pathol | volume = 18 | issue = 2 | pages = 103-20 | month = Apr | year = 2010 | doi = 10.1177/1066896908330049 | PMID = 19124452 }}</ref> | '''Pulmonary blastoma''' is a very rare tumour of the [[lung]]. These tumours are often lumped into the ''[[pulmonary sarcomatoid carcinomas]]'' group.<ref name=pmid19124452>{{Cite journal | last1 = Pelosi | first1 = G. | last2 = Sonzogni | first2 = A. | last3 = De Pas | first3 = T. | last4 = Galetta | first4 = D. | last5 = Veronesi | first5 = G. | last6 = Spaggiari | first6 = L. | last7 = Manzotti | first7 = M. | last8 = Fumagalli | first8 = C. | last9 = Bresaola | first9 = E. | title = Review article: pulmonary sarcomatoid carcinomas: a practical overview. | journal = Int J Surg Pathol | volume = 18 | issue = 2 | pages = 103-20 | month = Apr | year = 2010 | doi = 10.1177/1066896908330049 | PMID = 19124452 }}</ref> | ||
The article deals with ''well-differentiated fetal adenocarcinoma'' and ''classic biphasic pulmonary blastoma''. | |||
[[Pleuropulmonary blastoma]] is dealt with in a separate article. | |||
==General== | ==General== | ||
*Very rare ~ 100 cases in the literature.<ref name=pmid23049565 >{{Cite journal | last1 = Alahwal | first1 = MS. | last2 = Maniyar | first2 = IH. | last3 = Saleem | first3 = F. | last4 = Alshiekh | first4 = M. | title = Pulmonary blastoma: a rare primary lung malignancy. | journal = Case Rep Med | volume = 2012 | issue = | pages = 471613 | month = | year = 2012 | doi = 10.1155/2012/471613 | PMID = 23049565 | PMC = 3461274 }}</ref> | *Very rare ~ 100 cases in the literature.<ref name=pmid23049565 >{{Cite journal | last1 = Alahwal | first1 = MS. | last2 = Maniyar | first2 = IH. | last3 = Saleem | first3 = F. | last4 = Alshiekh | first4 = M. | title = Pulmonary blastoma: a rare primary lung malignancy. | journal = Case Rep Med | volume = 2012 | issue = | pages = 471613 | month = | year = 2012 | doi = 10.1155/2012/471613 | PMID = 23049565 | PMC = 3461274 }}</ref> | ||
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*Well-differentiated fetal adenocarcinoma (WDFA). | *Well-differentiated fetal adenocarcinoma (WDFA). | ||
*Classic biphasic pulmonary blastoma (CBPB). | *Classic biphasic pulmonary blastoma (CBPB). | ||
*Pleuropulmonary blastoma. | *[[Pleuropulmonary blastoma]]. | ||
**Now considered a separate entity.<ref name=pmid21513998>{{Cite journal | last1 = Van Loo | first1 = S. | last2 = Boeykens | first2 = E. | last3 = Stappaerts | first3 = I. | last4 = Rutsaert | first4 = R. | title = Classic biphasic pulmonary blastoma: a case report and review of the literature. | journal = Lung Cancer | volume = 73 | issue = 2 | pages = 127-32 | month = Aug | year = 2011 | doi = 10.1016/j.lungcan.2011.03.018 | PMID = 21513998 }}</ref> | **Now considered a separate entity.<ref name=pmid21513998>{{Cite journal | last1 = Van Loo | first1 = S. | last2 = Boeykens | first2 = E. | last3 = Stappaerts | first3 = I. | last4 = Rutsaert | first4 = R. | title = Classic biphasic pulmonary blastoma: a case report and review of the literature. | journal = Lung Cancer | volume = 73 | issue = 2 | pages = 127-32 | month = Aug | year = 2011 | doi = 10.1016/j.lungcan.2011.03.018 | PMID = 21513998 }}</ref> | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Epithelial component | *Epithelial component. | ||
*Mesenchymal component | *Mesenchymal component. | ||
**Small round cells. | **Small round cells. | ||
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*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461274/figure/fig4/ Pulmonary blastoma (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461274/figure/fig4/ Pulmonary blastoma (nih.gov)]. | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461274/figure/fig3/ Pulmonary blastoma (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461274/figure/fig3/ Pulmonary blastoma (nih.gov)]. | ||
*[http://path.upmc.edu/cases/case46/dx.html Fetal type adenocarcinoma (upmc.edu)]. | |||
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?s=20080802170406269 Pulmonary blastoma (surgicalpathologyatlas.com)]. | |||
*[http://www.flickr.com/photos/pulmonary_pathology/5463058190/ Pulmonary blastoma (flickr.com/Yale Rosen)]. | |||
==IHC== | ==IHC== | ||
Features:<ref>{{Cite journal | last1 = Zhang | first1 = GQ. | last2 = Fang | first2 = XZ. | last3 = Wang | first3 = BQ. | last4 = Sun | first4 = W. | last5 = Salai | first5 = AD. | title = [Clinicopathological and immunohistochemical features of pulmonary blastoma: analysis of 4 cases and review of the literature]. | journal = Zhonghua Yi Xue Za Zhi | volume = 87 | issue = 15 | pages = 1040-2 | month = Apr | year = 2007 | doi = | PMID = 17672968 }}</ref> | Features:<ref>{{Cite journal | last1 = Zhang | first1 = GQ. | last2 = Fang | first2 = XZ. | last3 = Wang | first3 = BQ. | last4 = Sun | first4 = W. | last5 = Salai | first5 = AD. | title = [Clinicopathological and immunohistochemical features of pulmonary blastoma: analysis of 4 cases and review of the literature]. | journal = Zhonghua Yi Xue Za Zhi | volume = 87 | issue = 15 | pages = 1040-2 | month = Apr | year = 2007 | doi = | PMID = 17672968 }}</ref> | ||
*TTF-1 +ve. | *[[TTF-1]] +ve. | ||
*S-100 -ve. | *S-100 -ve. | ||
*Vimentin -ve.{{fact}} | *Vimentin -ve.{{fact}} | ||
*EMA -ve. | *[[EMA]] -ve. | ||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Latest revision as of 04:46, 18 November 2015
Pulmonary blastoma is a very rare tumour of the lung. These tumours are often lumped into the pulmonary sarcomatoid carcinomas group.[1]
The article deals with well-differentiated fetal adenocarcinoma and classic biphasic pulmonary blastoma. Pleuropulmonary blastoma is dealt with in a separate article.
General
- Very rare ~ 100 cases in the literature.[2]
- Abysmal prognosis - 5-year survival ~ 15%.[2]
- Typical patient <20 years old.
- Adults usu. in 40s.[3]
- Resemble immature lung tissue.[4]
Classification
Traditionally subdivided into:[5]
- Well-differentiated fetal adenocarcinoma (WDFA).
- Classic biphasic pulmonary blastoma (CBPB).
- Pleuropulmonary blastoma.
- Now considered a separate entity.[6]
Gross
- Lung tumour.
Microscopic
Features:
- Epithelial component.
- Mesenchymal component.
- Small round cells.
DDx:
Images
- Pulmonary blastoma (nih.gov).
- Pulmonary blastoma (nih.gov).
- Fetal type adenocarcinoma (upmc.edu).
- Pulmonary blastoma (surgicalpathologyatlas.com).
- Pulmonary blastoma (flickr.com/Yale Rosen).
IHC
Features:[7]
- TTF-1 +ve.
- S-100 -ve.
- Vimentin -ve.[citation needed]
- EMA -ve.
See also
References
- ↑ Pelosi, G.; Sonzogni, A.; De Pas, T.; Galetta, D.; Veronesi, G.; Spaggiari, L.; Manzotti, M.; Fumagalli, C. et al. (Apr 2010). "Review article: pulmonary sarcomatoid carcinomas: a practical overview.". Int J Surg Pathol 18 (2): 103-20. doi:10.1177/1066896908330049. PMID 19124452.
- ↑ 2.0 2.1 Alahwal, MS.; Maniyar, IH.; Saleem, F.; Alshiekh, M. (2012). "Pulmonary blastoma: a rare primary lung malignancy.". Case Rep Med 2012: 471613. doi:10.1155/2012/471613. PMC 3461274. PMID 23049565. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461274/.
- ↑ Jethava, A.; Dasanu, CA. (Jan 2013). "Adult biphasic pulmonary blastoma.". Conn Med 77 (1): 19-22. PMID 23427368.
- ↑ Schulze, SM.; Sbayi, S.; Costic, JT.; Moser, RL. (Dec 2005). "A rare case of classic biphasic pulmonary blastoma.". Am Surg 71 (12): 1078-81. PMID 16447486.
- ↑ Walker, RI.; Suvarna, K.; Matthews, S. (May 2005). "Case report: pulmonary blastoma: presentation of two atypical cases and review of the literature.". Br J Radiol 78 (929): 437-40. doi:10.1259/bjr/45172814. PMID 15845939.
- ↑ Van Loo, S.; Boeykens, E.; Stappaerts, I.; Rutsaert, R. (Aug 2011). "Classic biphasic pulmonary blastoma: a case report and review of the literature.". Lung Cancer 73 (2): 127-32. doi:10.1016/j.lungcan.2011.03.018. PMID 21513998.
- ↑ Zhang, GQ.; Fang, XZ.; Wang, BQ.; Sun, W.; Salai, AD. (Apr 2007). "[Clinicopathological and immunohistochemical features of pulmonary blastoma: analysis of 4 cases and review of the literature].". Zhonghua Yi Xue Za Zhi 87 (15): 1040-2. PMID 17672968.