Gallbladder cholesterolosis: Difference between revisions
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| Micro = abundant foamy macrophages in the lamina propria, +/-papillary hyperplasia | | Micro = abundant foamy macrophages in the lamina propria, +/-papillary hyperplasia | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[cholesterol polyp of gallbladder]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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==General== | ==General== | ||
*Common in [[chronic cholecystitis]]. | *Common in [[chronic cholecystitis]]. | ||
*Seen in ~13% of cases in a large series of 23,304 gallbladders.<ref name=pmid21043073>{{Cite journal | last1 = Roa | first1 = I. | last2 = de Aretxabala | first2 = X. | last3 = Ibacache | first3 = G. | last4 = Muñoz | first4 = S. | title = [Association between cholesterolosis and gallbladder cancer]. | journal = Rev Med Chil | volume = 138 | issue = 7 | pages = 804-8 | month = Jul | year = 2010 | doi = | PMID = 21043073 }}</ref> | |||
**Slightly more common in women than men (14% of cases in women versus 10% of cases in men). | |||
*Less likely to be associated with cancer than gallbladders without cholesterolosis; relative risk of cancer in non-cholesterolosis gallbladders 9.2.<ref name=pmid21043073/> | |||
*Associated with yellow [[gallstones]] (cholesterol type gallstones). | *Associated with yellow [[gallstones]] (cholesterol type gallstones). | ||
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Image:Cholesterolosis_of_the_Gallbladder.jpg | Gallbladder cholesterolosis. (WC/euthman) | Image:Cholesterolosis_of_the_Gallbladder.jpg | Gallbladder cholesterolosis. (WC/euthman) | ||
</gallery> | </gallery> | ||
==Microscopic== | |||
Features: | Features: | ||
*Numerous foamy macrophages in the lamina propria. | *Numerous foamy macrophages in the lamina propria. | ||
*+/-Papillary hyperplasia.<ref name=pmid7990683>{{Cite journal | last1 = Celoria | first1 = GC. | last2 = Rodríguez Otero | first2 = JC. | last3 = Proske | first3 = SA. | last4 = Vallilengua | first4 = C. | title = Papillary hyperplasia and cholesterolosis of the gallbladder. | journal = Medicina (B Aires) | volume = 54 | issue = 1 | pages = 31-4 | month = | year = 1994 | doi = | PMID = 7990683 }}</ref> | *+/-Papillary hyperplasia.<ref name=pmid7990683>{{Cite journal | last1 = Celoria | first1 = GC. | last2 = Rodríguez Otero | first2 = JC. | last3 = Proske | first3 = SA. | last4 = Vallilengua | first4 = C. | title = Papillary hyperplasia and cholesterolosis of the gallbladder. | journal = Medicina (B Aires) | volume = 54 | issue = 1 | pages = 31-4 | month = | year = 1994 | doi = | PMID = 7990683 }}</ref> | ||
DDx: | |||
*[[Cholesterol polyp of gallbladder]] - polypoid shape. | |||
===Image=== | |||
<gallery> | <gallery> | ||
Image:Gallbladder_cholesterolosis_intermed_mag_cropped.jpg | Cholesterolosis - intermed. mag. (WC) | Image:Gallbladder_cholesterolosis_intermed_mag_cropped.jpg | Cholesterolosis - intermed. mag. (WC) | ||