Difference between revisions of "Gallbladder cholesterolosis"
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| Micro = abundant foamy macrophages in the lamina propria, +/-papillary hyperplasia | | Micro = abundant foamy macrophages in the lamina propria, +/-papillary hyperplasia | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[cholesterol polyp of gallbladder]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 14: | Line 14: | ||
| Gross = gallbladder mucosa with strawberry-like texture | | Gross = gallbladder mucosa with strawberry-like texture | ||
| Grossing = | | Grossing = | ||
| Site = [[gallbladder] | | Site = [[gallbladder]] | ||
| Assdx = [[chronic cholecystitis]], [[obesity]], [[cholelithiasis]] | | Assdx = [[chronic cholecystitis]], [[obesity]], [[cholelithiasis]] | ||
| Syndromes = | | Syndromes = | ||
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==General== | ==General== | ||
*Common in [[cholecystitis]]. | *Common in [[chronic cholecystitis]]. | ||
*Associated with yellow gallstones (cholesterol type gallstones). | *Seen in ~13% of cases in a large series of 23,304 gallbladders.<ref name=pmid21043073>{{Cite journal | last1 = Roa | first1 = I. | last2 = de Aretxabala | first2 = X. | last3 = Ibacache | first3 = G. | last4 = Muñoz | first4 = S. | title = [Association between cholesterolosis and gallbladder cancer]. | journal = Rev Med Chil | volume = 138 | issue = 7 | pages = 804-8 | month = Jul | year = 2010 | doi = | PMID = 21043073 }}</ref> | ||
**Slightly more common in women than men (14% of cases in women versus 10% of cases in men). | |||
*Less likely to be associated with cancer than gallbladders without cholesterolosis; relative risk of cancer in non-cholesterolosis gallbladders 9.2.<ref name=pmid21043073/> | |||
*Associated with yellow [[gallstones]] (cholesterol type gallstones). | |||
==Gross== | ==Gross== | ||
| Line 46: | Line 49: | ||
Image:Cholesterolosis_of_the_Gallbladder.jpg | Gallbladder cholesterolosis. (WC/euthman) | Image:Cholesterolosis_of_the_Gallbladder.jpg | Gallbladder cholesterolosis. (WC/euthman) | ||
</gallery> | </gallery> | ||
==Microscopic== | |||
Features: | Features: | ||
*Numerous foamy macrophages in the lamina propria. | *Numerous foamy macrophages in the lamina propria. | ||
*+/-Papillary hyperplasia.<ref name=pmid7990683>{{Cite journal | last1 = Celoria | first1 = GC. | last2 = Rodríguez Otero | first2 = JC. | last3 = Proske | first3 = SA. | last4 = Vallilengua | first4 = C. | title = Papillary hyperplasia and cholesterolosis of the gallbladder. | journal = Medicina (B Aires) | volume = 54 | issue = 1 | pages = 31-4 | month = | year = 1994 | doi = | PMID = 7990683 }}</ref> | *+/-Papillary hyperplasia.<ref name=pmid7990683>{{Cite journal | last1 = Celoria | first1 = GC. | last2 = Rodríguez Otero | first2 = JC. | last3 = Proske | first3 = SA. | last4 = Vallilengua | first4 = C. | title = Papillary hyperplasia and cholesterolosis of the gallbladder. | journal = Medicina (B Aires) | volume = 54 | issue = 1 | pages = 31-4 | month = | year = 1994 | doi = | PMID = 7990683 }}</ref> | ||
DDx: | |||
*[[Cholesterol polyp of gallbladder]] - polypoid shape. | |||
===Image=== | |||
<gallery> | <gallery> | ||
Image:Gallbladder_cholesterolosis_intermed_mag_cropped.jpg | Cholesterolosis - intermed. mag. (WC) | Image:Gallbladder_cholesterolosis_intermed_mag_cropped.jpg | Cholesterolosis - intermed. mag. (WC) | ||
Latest revision as of 05:02, 1 June 2016
| Gallbladder cholesterolosis | |
|---|---|
| Diagnosis in short | |
 Gallbladder cholesterolosis. H&E stain. | |
|
| |
| LM | abundant foamy macrophages in the lamina propria, +/-papillary hyperplasia |
| LM DDx | cholesterol polyp of gallbladder |
| Gross | gallbladder mucosa with strawberry-like texture |
| Site | gallbladder |
|
| |
| Associated Dx | chronic cholecystitis, obesity, cholelithiasis |
| Clinical history | biliary colic - due to chronic cholecystitis |
| Prevalence | common |
| Prognosis | benign |
Gallbladder cholesterolosis, also known simply as cholesterolosis, is a common gallbladder pathology associated with chronic cholecystitis.
Informally, gallbladder cholesterolosis is known as strawberry gallbladder.
General
- Common in chronic cholecystitis.
- Seen in ~13% of cases in a large series of 23,304 gallbladders.[1]
- Slightly more common in women than men (14% of cases in women versus 10% of cases in men).
- Less likely to be associated with cancer than gallbladders without cholesterolosis; relative risk of cancer in non-cholesterolosis gallbladders 9.2.[1]
- Associated with yellow gallstones (cholesterol type gallstones).
Gross
Features:
- Mucosa has strawberry-like appearance.
- The similarity is in the surface texture.
- The colour (yellow) is not strawberry-like.
Image
Gallbladder cholesterolosis. (WC/euthman)
Microscopic
Features:
- Numerous foamy macrophages in the lamina propria.
- +/-Papillary hyperplasia.[2]
DDx:
- Cholesterol polyp of gallbladder - polypoid shape.
Image
Cholesterolosis - intermed. mag. (WC)
Cholesterolosis. (WC)
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GALLBLADDER, CHOLECYSTECTOMY: - CHRONIC CHOLECYSTITIS WITH CHOLESTEROLOSIS. - CHOLELITHIASIS.
GALLBLADDER, CHOLECYSTECTOMY: - CHRONIC CHOLECYSTITIS WITH FOCAL FOAMY MACROPHAGES IN LAMINA PROPRIA. - CHOLELITHIASIS.
See also
References
- ↑ 1.0 1.1 Roa, I.; de Aretxabala, X.; Ibacache, G.; Muñoz, S. (Jul 2010). "[Association between cholesterolosis and gallbladder cancer].". Rev Med Chil 138 (7): 804-8. PMID 21043073.
- ↑ Celoria, GC.; Rodríguez Otero, JC.; Proske, SA.; Vallilengua, C. (1994). "Papillary hyperplasia and cholesterolosis of the gallbladder.". Medicina (B Aires) 54 (1): 31-4. PMID 7990683.