Dermatofibroma: Difference between revisions
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| Caption = Dermatofibroma. [[H&E stain]]. | | Caption = Dermatofibroma. [[H&E stain]]. | ||
| Micro = | | Micro = prominent fibrous bundles - especially at the edge of the lesion ("collagen-trapping"), loss of adnexal structures, +/-"dirty fingers" ([[acanthosis]], basal keratinocyte hyperpigmentation) | ||
| Subtypes = | | Subtypes = cellular, deep penetrating, lipidized, epithelioid cell histiocytoma, fibrotic, aneurysmal, granular cell dermatofibroma, dermatofibroma with monster cells | ||
| LMDDx = [[DFSP]], [[neurofibroma]], [[blue nevus]], [[melanoma]], esp. desmoplastic neurotropic-type, [[fibromatosis]] | | LMDDx = [[DFSP]], [[neurofibroma]], [[blue nevus]], [[melanoma]], esp. desmoplastic neurotropic-type, [[fibromatosis]] | ||
| Stains = | | Stains = | ||
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| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = common | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
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==General== | ==General== | ||
* | *Classically considered a reactive process - ''not'' a neoplasm. | ||
*Usually associated with previous trauma. | *Usually associated with previous trauma. | ||
**In women... usually legs. | **In women... usually legs. | ||
*Multiple dermatofibromas are described in association [[Down syndrome]].<ref name=pmid36219648>{{cite journal |authors=Zimmerman TJ, George SJ |title=Multiple Eruptive Dermatofibromas Associated With Down Syndrome |journal=Cutis |volume=110 |issue=2 |pages=E21–E23 |date=August 2022 |pmid=36219648 |doi=10.12788/cutis.0600 |url=}}</ref><ref name=pmid23879455>{{cite journal |authors=Lamb RC, Gangopadhyay M, MacDonald A |title=Multiple dermatofibromas in Down syndrome |journal=Int J Dermatol |volume=53 |issue=4 |pages=e274–5 |date=April 2014 |pmid=23879455 |doi=10.1111/ijd.12037 |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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*[[Melanoma]], esp. desmoplastic neurotropic-type. | *[[Melanoma]], esp. desmoplastic neurotropic-type. | ||
*[[Fibromatosis]]. | *[[Fibromatosis]]. | ||
*[[Dermal scar]]. | |||
Images: | Images: | ||
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*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802171836877 Cellular dermatofibroma (surgicalpathologyatlas.com)]. | *[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802171836877 Cellular dermatofibroma (surgicalpathologyatlas.com)]. | ||
*[http://www.dermpedia.org/node/2292 Cellular dermatofibroma (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans# http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans#]. Accessed on: 4 February 2012.</ref> | *[http://www.dermpedia.org/node/2292 Cellular dermatofibroma (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans# http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans#]. Accessed on: 4 February 2012.</ref> | ||
===Epithelioid cell histiocytoma=== | |||
Features: | |||
*Epithelioid cells. | |||
*No lesional cells in epidermis. | |||
DDx: | |||
*[[Melanocytic lesions]] - esp. [[malignant melanoma]]. | |||
==IHC== | ==IHC== | ||
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</pre> | </pre> | ||
<pre> | |||
SKIN LESION, LEFT UPPER ARM, EXCISION: | |||
- DERMATOFIBROMA. | |||
COMMENT: | |||
The histologic impression is supported by immunostains; a CD34 immunostain | |||
is negative and a factor XIIIa immunostain is weakly positive. | |||
</pre> | |||
===Micro=== | ===Micro=== | ||
The sections show skin with bland spindle cells interspersed between fibrous bundles. | The sections show skin with bland spindle cells interspersed between fibrous bundles. | ||