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| Image: | | Image: |
| *[http://commons.wikimedia.org/wiki/File:Tooth_in_teratoma_-_very_low_mag.jpg Tooth (WC)].
| | <gallery> |
| | Image:Tooth_in_teratoma_-_very_low_mag.jpg | Tooth. (WC) |
| | </gallery> |
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| ===Enamel 101=== | | ===Enamel 101=== |
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| ==Ameloblastoma== | | ==Ameloblastoma== |
| ===General===
| | {{Main|Ameloblastoma}} |
| *Osteous lesion.
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| *Usually mandible.<ref>URL: [http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm http://www.waent.org/archives/2010/Vol3-2/20100618-ameloblastoma/jaw-tumor.htm]. Accessed on: 30 November 2011.</ref>
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| **In a review of 3677 cases, the mandible-to-maxilla ratio was 5 to 1.<ref name=pmid7633291>{{Cite journal | last1 = Reichart | first1 = PA. | last2 = Philipsen | first2 = HP. | last3 = Sonner | first3 = S. | title = Ameloblastoma: biological profile of 3677 cases. | journal = Eur J Cancer B Oral Oncol | volume = 31B | issue = 2 | pages = 86-99 | month = Mar | year = 1995 | doi = | PMID = 7633291 }}</ref>
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| *May arise from an odontogenic cyst,<ref name=pmid10587275>{{Cite journal | last1 = Eversole | first1 = LR. | title = Malignant epithelial odontogenic tumors. | journal = Semin Diagn Pathol | volume = 16 | issue = 4 | pages = 317-24 | month = Nov | year = 1999 | doi = | PMID = 10587275 }}</ref> e.g. [[dentigerous cyst]].<ref name=pmid21957386>{{Cite journal | last1 = Moosvi | first1 = Z. | last2 = Tayaar | first2 = SA. | last3 = Kumar | first3 = GS. | title = Neoplastic potential of odontogenic cysts. | journal = Contemp Clin Dent | volume = 2 | issue = 2 | pages = 106-9 | month = Apr | year = 2011 | doi = 10.4103/0976-237X.83073 | PMID = 21957386 | PMC = 3180832 }}</ref>
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| ===Classification===
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| Location:
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| #Intra-osseous.
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| #*Locally aggressive.
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| #Peripheral.
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| #*Benign.
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| ====Subclassification of intra-osseous type====
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| Histology:
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| #Solid/multicystic.
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| #*More commonly reoccur.
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| #Unicystic.
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| #*Unlikely to reoccur.
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| #*Classically found in younger individuals.
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| ===Microscopic===
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| Features:<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970616-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970616-7]. Accessed on: March 9, 2010.</ref>
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| *Stellate reticulum - star-shaped cells, found in a developing tooth.
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| *Tall columnar cells.
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| **Palisaded nuclei with reverse polarization.
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| ***Reverse polarization of nuclei = nuclei distant from the basement membrane/nuclei at pole opposite of basement membrane.
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| ***Palisaded nuclei = picket fence appearance; columnar-shaped nuclei with long axis perpendicular to the basement membrane -- '''key feature'''.
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| **Subnuclear vacuolization.
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| *+/-Giant cells.
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| *+/-Subepithelial hyalinization (eosinophilic acellular amorphous material).
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| **Seen deep to the basement membrane.
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| *Variable morphology (see below - ''morphology'').
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| DDx (nuclear palisading):
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| *[[Adenomatoid odontogenic tumour]].
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| *[[Ameloblastic fibroma]].
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| Images:
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| *www:
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| **[http://www.estomatologia.com.br/diagnosticos_det2.asp?cod_diag=12 Ameloblastoma - several images (estomatologia.com.br)].
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| **[http://www.cytochemistry.net/microanatomy/digestive/devtooth9.jpg Stellate reticulum (cytochemistry.net)].
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| *[[WC]]:
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| **[http://commons.wikimedia.org/wiki/File:Ameloblastoma_-_intermed_mag.jpg Ameloblastoma - intermed. mag. (WC)].
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| **[http://commons.wikimedia.org/wiki/File:Ameloblastoma_-_very_high_mag.jpg Ameloblastoma - very high mag.j (WC)].
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| ====Morphology====
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| *Not prognostic.
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| Morphologic variants:
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| *Follicular ameloblastoma (classic appearance).
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| *Plexiform ameloblastoma (does not have prominent palisading).
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| *Acanthomatous ameloblastoma.
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| *Desmoplastic ameloblastoma.
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| *Basaloid ameloblastoma.
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| ==Adenomatoid odontogenic tumour== | | ==Adenomatoid odontogenic tumour== |
| ===General===
| | {{Main|Adenomatoid odontogenic tumour}} |
| *Paedatric population.
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| ===Microscopic===
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| Features:
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| *Palisaded nuclei.
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| *Whorled epithelium.
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| Notes:
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| *No stellate reticulum.
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| DDx:
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| *[[Ameloblastoma]].
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| Image:
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| *[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170145276 AOT (surgical pathologyatlas.com)].
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| ==Ameloblastic fibroma== | | ==Ameloblastic fibroma== |
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| Features: | | Features: |
| *Paucicellular lesion with pale staining. | | *Paucicellular lesion with pale staining. |
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| | ==Squamous odontogenic tumour== |
| | {{Main|Squamous odontogenic tumour}} |
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| =See also= | | =See also= |