Difference between revisions of "Inflammatory fibroid polyp"
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| Width = | | Width = | ||
| Caption = Inflammatory fibroid polyp. [[H&E stain]]. | | Caption = Inflammatory fibroid polyp. [[H&E stain]]. | ||
| Micro = proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils ( | | Micro = proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils (usually prominent), +/-leiomyoma/schwannoma-like areas - with nuclear palisading | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[inflammatory myofibroblastic tumour]], [[GIST]], [[schwannoma]] | | LMDDx = [[inflammatory myofibroblastic tumour]], [[GIST]], [[hemangiopericytoma]], [[eosinophilic gastritis]], [[schwannoma]] | ||
| Stains = | | Stains = | ||
| IHC = CD34 +ve, vimentin +ve, CD117 -ve, S-100 -ve | | IHC = CD34 +ve, vimentin +ve, CD117 -ve, S-100 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = +/-PDGFRA mutations | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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| ClinDDx = | | ClinDDx = | ||
}} | }} | ||
'''Inflammatory fibroid polyp''' is an uncommon [[gastrointestinal polyp]]. | '''Inflammatory fibroid polyp''', abbreviated '''IFP''', is an uncommon [[gastrointestinal polyp]]. | ||
==General== | ==General== | ||
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*Through-out GI tract. | *Through-out GI tract. | ||
*Can be thought of as granulation tissue-like.<ref name=Ref_DCHH138/> | *Can be thought of as granulation tissue-like.<ref name=Ref_DCHH138/> | ||
*Uncommon. | |||
==Microscopic== | ==Microscopic== | ||
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*+/-Vascular for fibrous tissue. | *+/-Vascular for fibrous tissue. | ||
*Poorly circumscribed/infiltrates into the lamina propria. | *Poorly circumscribed/infiltrates into the lamina propria. | ||
*+/-Myxoid stroma.<ref name=pmid24764778>{{Cite journal | last1 = Islam | first1 = RS. | last2 = Patel | first2 = NC. | last3 = Lam-Himlin | first3 = D. | last4 = Nguyen | first4 = CC. | title = Gastric polyps: a review of clinical, endoscopic, and histopathologic features and management decisions. | journal = Gastroenterol Hepatol (N Y) | volume = 9 | issue = 10 | pages = 640-51 | month = Oct | year = 2013 | doi = | PMID = 24764778 }}</ref> | |||
DDx: | Notes: | ||
*Concentric = share the same centre.<ref>URL: [http://dictionary.reference.com/browse/concentric http://dictionary.reference.com/browse/concentric]. Accessed on: 29 November 2011.</ref> | |||
DDx:<ref name=pmid22759473>{{Cite journal | last1 = Rossi | first1 = P. | last2 = Montuori | first2 = M. | last3 = Balassone | first3 = V. | last4 = Ricciardi | first4 = E. | last5 = Anemona | first5 = L. | last6 = Manzelli | first6 = A. | last7 = Petrella | first7 = G. | title = Inflammatory fibroid polyp. A case report and review of the literature. | journal = Ann Ital Chir | volume = 83 | issue = 4 | pages = 347-51 | month = | year = | doi = | PMID = 22759473 }}</ref> | |||
*[[Inflammatory myofibroblastic tumour]]. | *[[Inflammatory myofibroblastic tumour]]. | ||
*[[GIST]] - usually sharply demarcated border. | *[[GIST]] - usually sharply demarcated border. | ||
*[[Hemangiopericytoma]]. | |||
*[[Eosinophilic gastritis]]. | |||
* | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image: Inflammatory fibroid polyp - low mag.jpg | Low mag. | ||
Image: | Image: Inflammatory fibroid polyp - intermed mag.jpg | Intermed. mag. | ||
Image: Inflammatory fibroid polyp - 2 - high mag.jpg | High mag. | |||
Image: Inflammatory fibroid polyp - high mag.jpg | High mag. | |||
Image: Inflammatory fibroid polyp - very high mag.jpg | Very high mag. | |||
</gallery> | </gallery> | ||
Line 69: | Line 76: | ||
</ref> | </ref> | ||
*S100 -ve. | *S100 -ve. | ||
*Cyclin D1 +ve.<ref name=pmid14707872>{{Cite journal | last1 = Pantanowitz | first1 = L. | last2 = Antonioli | first2 = DA. | last3 = Pinkus | first3 = GS. | last4 = Shahsafaei | first4 = A. | last5 = Odze | first5 = RD. | title = Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin. | journal = Am J Surg Pathol | volume = 28 | issue = 1 | pages = 107-14 | month = Jan | year = 2004 | doi = | PMID = 14707872 }}</ref> | |||
==Molecular== | ==Molecular== | ||
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==See also== | ==See also== | ||
*[[Stomach]]. | *[[Stomach]]. | ||
*[[Gastrointestinal tract polyps]]. | |||
==References== | ==References== |
Latest revision as of 18:56, 6 December 2015
Inflammatory fibroid polyp | |
---|---|
Diagnosis in short | |
Inflammatory fibroid polyp. H&E stain. | |
| |
LM | proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils (usually prominent), +/-leiomyoma/schwannoma-like areas - with nuclear palisading |
LM DDx | inflammatory myofibroblastic tumour, GIST, hemangiopericytoma, eosinophilic gastritis, schwannoma |
IHC | CD34 +ve, vimentin +ve, CD117 -ve, S-100 -ve |
Molecular | +/-PDGFRA mutations |
Site | stomach, other places in the GI tract |
| |
Prevalence | uncommon |
Prognosis | good - benign |
Inflammatory fibroid polyp, abbreviated IFP, is an uncommon gastrointestinal polyp.
General
- Benign.
- Through-out GI tract.
- Can be thought of as granulation tissue-like.[1]
- Uncommon.
Microscopic
Features:[2]
- Proliferating spindle cells (fibroid) - key feature.
- Inflammation:
- Eosinophils - often prominent.
- +/-Leiomyoma/schwannoma-like areas - with nuclear palisading.[1]
- +/-Vascular for fibrous tissue.
- Poorly circumscribed/infiltrates into the lamina propria.
- +/-Myxoid stroma.[4]
Notes:
- Concentric = share the same centre.[5]
DDx:[6]
- Inflammatory myofibroblastic tumour.
- GIST - usually sharply demarcated border.
- Hemangiopericytoma.
- Eosinophilic gastritis.
Images
IHC
Features:[2]
- CD34 +ve.
- There is a CD34 -ve variant.
- Vimentin +ve -- diffuse.[7]
Others:
Molecular
- A subset have mutations in PDGFRA.[2]
See also
References
- ↑ 1.0 1.1 1.2 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 138. ISBN 978-0470519035.
- ↑ 2.0 2.1 2.2 Daum, O.; Hatlova, J.; Mandys, V.; Grossmann, P.; Mukensnabl, P.; Benes, Z.; Michal, M. (May 2010). "Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors).". Virchows Arch 456 (5): 491-7. doi:10.1007/s00428-010-0914-8. PMID 20393746.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 115. ISBN 978-0443066573.
- ↑ Islam, RS.; Patel, NC.; Lam-Himlin, D.; Nguyen, CC. (Oct 2013). "Gastric polyps: a review of clinical, endoscopic, and histopathologic features and management decisions.". Gastroenterol Hepatol (N Y) 9 (10): 640-51. PMID 24764778.
- ↑ URL: http://dictionary.reference.com/browse/concentric. Accessed on: 29 November 2011.
- ↑ Rossi, P.; Montuori, M.; Balassone, V.; Ricciardi, E.; Anemona, L.; Manzelli, A.; Petrella, G.. "Inflammatory fibroid polyp. A case report and review of the literature.". Ann Ital Chir 83 (4): 347-51. PMID 22759473.
- ↑ Kolodziejczyk, P.; Yao, T.; Tsuneyoshi, M. (Nov 1993). "Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases.". Am J Surg Pathol 17 (11): 1159-68. PMID 8214261.
- ↑ Ozolek, JA.; Sasatomi, E.; Swalsky, PA.; Rao, U.; Krasinskas, A.; Finkelstein, SD. (Mar 2004). "Inflammatory fibroid polyps of the gastrointestinal tract: clinical, pathologic, and molecular characteristics.". Appl Immunohistochem Mol Morphol 12 (1): 59-66. PMID 15163021.
- ↑ Pantanowitz, L.; Antonioli, DA.; Pinkus, GS.; Shahsafaei, A.; Odze, RD. (Jan 2004). "Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin.". Am J Surg Pathol 28 (1): 107-14. PMID 14707872.