Spermatocytic tumour: Difference between revisions
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| Image = Spermatocytic_seminoma_high_mag.jpg | | Image = Spermatocytic_seminoma_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = Spermatocytic seminoma | | Caption = Spermatocytic tumour | ||
| Micro = three cell | | Synonyms = spermatocytic seminoma (old term, not recommended by World Health Organization) | ||
| Micro = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread | |||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[DLBCL]], [[seminoma]] | | LMDDx = [[DLBCL]], [[seminoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = SALL4 +ve, OCT3/4 -ve, CD117 +ve/-ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Signs = mass lesion | | Signs = mass lesion | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Line 27: | Line 28: | ||
| Other = | | Other = | ||
| ClinDDx = other [[germ cell tumours]], [[lymphoma]] | | ClinDDx = other [[germ cell tumours]], [[lymphoma]] | ||
| Tx = excision to exclude malignancy | |||
}} | }} | ||
''' | '''Spermatocytic tumour''' is a rare benign testicular tumour. | ||
It was previously known as '''spermatocytic seminoma'''. It should ''not'' be confused with [[seminoma]] which is an unrelated tumour. | |||
==General== | ==General== | ||
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===Epidemiology=== | ===Epidemiology=== | ||
*Does | *Does ''not'' arise from ''[[germ cell neoplasia in situ]]'' (previously known as ''intratubular germ cell neoplasia'')<ref name=pmid3583416>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of [[seminoma]]. | ||
==Microscopic== | ==Microscopic== | ||
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===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Spermatocytic_seminoma_high_mag.jpg | Spermatocytic | Image:Spermatocytic_seminoma_high_mag.jpg | Spermatocytic tumour - high mag. (WC) | ||
Image:Spermatocytic_seminoma_intermed_mag.jpg | Spermatocytic | Image:Spermatocytic_seminoma_intermed_mag.jpg | Spermatocytic tumour - intermed. mag. (WC) | ||
Image:testicular spermatocytic tumour high mag.jpg | Spermatocytic tumour - high mag. (WC) | |||
</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid10223302>{{Cite journal | last1 = Kraggerud | first1 = SM. | last2 = Berner | first2 = A. | last3 = Bryne | first3 = M. | last4 = Pettersen | first4 = EO. | last5 = Fossa | first5 = SD. | title = Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. | journal = APMIS | volume = 107 | issue = 3 | pages = 297-302 | month = Mar | year = 1999 | doi = | PMID = 10223302 }}</ref> | Features:<ref name=pmid10223302>{{Cite journal | last1 = Kraggerud | first1 = SM. | last2 = Berner | first2 = A. | last3 = Bryne | first3 = M. | last4 = Pettersen | first4 = EO. | last5 = Fossa | first5 = SD. | title = Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. | journal = APMIS | volume = 107 | issue = 3 | pages = 297-302 | month = Mar | year = 1999 | doi = | PMID = 10223302 }}</ref> | ||
*PLAP -ve (0 positive/17). | *[[PLAP]] -ve (0 positive/17). | ||
*CD117 -ve (7 positive/17). | *CD117 -ve (7 positive/17). | ||
*CAM5.2 -ve (1 positive/17). | *CAM5.2 -ve (1 positive/17). | ||
Others:<ref>{{Ref WHOGU2022|289}}</ref> | |||
*SALL4 +ve. | |||
*OCT3/4 -ve. | |||
*AFP -ve. | |||
*CD30 -ve. | |||
*Beta-hCG -ve. | |||
==Sign out== | |||
<pre> | |||
Left Testis, Radical Orchiectomy: | |||
- Spermatocytic tumour, see comment. | |||
- NEGATIVE for germ cell neoplasia in situ. | |||
- Background testis with spermatogenesis and atrophy. | |||
Comment: | |||
Spermatocytic tumours are rare. They are not associated with germ cell neoplasia in situ (GCNIS) and typically not seen together with other germ cell types. | |||
The tumour stains as follows: | |||
POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), BCL2 (scattered cells, moderate membranous). | |||
NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4, CAM5.2, D2-40. | |||
This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the World Health Organization, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS). | |||
</pre> | |||
===Micro=== | |||
This tumour has three cell types with spireme chromatin in the larger and intermediate cell type. Infiltrating lymphocytes are absent. | |||
The background testis has some spermatogenesis and atrophic change. Germ cell neoplasia in situ (GCNIS) is ABSENT. The seminiferous tubules adjacent to the tumour, where visualized, are atrophic. | |||
==See also== | ==See also== | ||