Difference between revisions of "Atypical lentiginous nevus"

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| Width      =
| Width      =
| Caption    =  
| Caption    =  
| Micro      = elongated rete ridges (key feature), superficial dermal fibrosis, diffuse (non-lamellar), mild-to-moderated cytologic atypia
| Micro      = elongated rete ridges (key feature), diffuse (non-lamellar) superficial dermal fibrosis, mild-to-moderated cytologic atypia
| Subtypes  =
| Subtypes  =
| LMDDx      = [[dysplastic nevus]], [[melanoma in situ]]
| LMDDx      = [[dysplastic nevus]], [[melanoma in situ]]
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| Molecular  =
| Molecular  =
| IF        =
| IF        =
| Gross      =
| Gross      =  
| Grossing  =
| Grossing  =
| Site      =
| Site      = [[skin]]
| Assdx      =
| Assdx      = [[malignant melanoma]]
| Syndromes  =
| Syndromes  =
| Clinicalhx = elderly population
| Signs      =
| Signs      =
| Symptoms  =
| Symptoms  =
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| Prognosis  =
| Prognosis  =
| Other      =
| Other      =
| ClinDDx    =
| ClinDDx    = [[melanoma]]
}}
}}
'''Atypical lentiginous nevus''', also '''atypical lentiginous nevus of the elderly''', is a [[melanocytic lesion]] associated with old age and melanoma.
'''Atypical lentiginous nevus''', also '''atypical lentiginous nevus of the elderly''', is a [[melanocytic lesion]] associated with old age and melanoma. It may be abbreviated '''ALN'''.


It can be considered a type of [[dysplastic nevus]].<ref name=pmid10911797>{{Cite journal  | last1 = Edwards | first1 = SL. | last2 = Blessing | first2 = K. | title = Problematic pigmented lesions: approach to diagnosis. | journal = J Clin Pathol | volume = 53 | issue = 6 | pages = 409-18 | month = Jun | year = 2000 | doi =  | PMID = 10911797 }}</ref><ref>{{Cite journal  | last1 = Kossard | first1 = S. | title = Atypical lentiginous junctional naevi of the elderly and melanoma. | journal = Australas J Dermatol | volume = 43 | issue = 2 | pages = 93-101 | month = May | year = 2002 | doi =  | PMID = 11982564 }}</ref>
It can be considered a type of [[dysplastic nevus]].<ref name=pmid10911797>{{Cite journal  | last1 = Edwards | first1 = SL. | last2 = Blessing | first2 = K. | title = Problematic pigmented lesions: approach to diagnosis. | journal = J Clin Pathol | volume = 53 | issue = 6 | pages = 409-18 | month = Jun | year = 2000 | doi =  | PMID = 10911797 }}</ref><ref>{{Cite journal  | last1 = Kossard | first1 = S. | title = Atypical lentiginous junctional naevi of the elderly and melanoma. | journal = Australas J Dermatol | volume = 43 | issue = 2 | pages = 93-101 | month = May | year = 2002 | doi =  | PMID = 11982564 }}</ref>
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==Microscopic==
==Microscopic==
Features:<ref name=pmid22421501>{{Cite journal  | last1 = Agustí-Mejias | first1 = A. | last2 = Messeguer Badia | first2 = F. | last3 = García Ruiz | first3 = R. | last4 = Oliver Martínez | first4 = V. | last5 = Alegre de Miquel | first5 = V. | title = [Atypical lentiginous nevus: a clinical and histopathologic study of 14 cases]. | journal = Actas Dermosifiliogr | volume = 103 | issue = 5 | pages = 394-400 | month = Jun | year = 2012 | doi = 10.1016/j.ad.2011.10.006 | PMID = 22421501 }}</ref>
Features:<ref name=pmid22421501>{{Cite journal  | last1 = Agustí-Mejias | first1 = A. | last2 = Messeguer Badia | first2 = F. | last3 = García Ruiz | first3 = R. | last4 = Oliver Martínez | first4 = V. | last5 = Alegre de Miquel | first5 = V. | title = [Atypical lentiginous nevus: a clinical and histopathologic study of 14 cases]. | journal = Actas Dermosifiliogr | volume = 103 | issue = 5 | pages = 394-400 | month = Jun | year = 2012 | doi = 10.1016/j.ad.2011.10.006 | PMID = 22421501 | URL = http://www.actasdermo.org/en/atypical-lentiginous-nevus-a-clinical/articulo/90149637/?pubmed=true }}</ref>
*Elongated rete ridges - '''key feature'''.
*Elongated rete ridges - '''key feature'''.
*Superficial dermal fibrosis, diffuse (non-lamellar) - '''important'''.
*Superficial dermal fibrosis, diffuse (non-lamellar) - '''important'''.
*Mild-to-moderate cytologic atypia.
*Mild-to-moderate cytologic atypia, focal.
 
Notes:<ref name=pmid22421501/>
*Rarely dermal nests.
*Mild-to-moderate inflammation.
*Mitoses - never.
*[[Solar elastosis]] - mild-to-moderate.


DDx:<ref name=pmid22421501/>
DDx:<ref name=pmid22421501/>
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*[[Dysplastic nevus]] - lamellar fibrosis.
*[[Dysplastic nevus]] - lamellar fibrosis.
*[[Lentigo simplex]].
*[[Lentigo simplex]].
*[[Lentigo maligna]].
*[[Lentigo maligna]] - more atypia, upward migration of melanocytes, occasional mitoses.
*[[Solar lentigo]].
*[[Solar lentigo]] - [[solar elastosis]].
*[[Lentiginous nevus]].
*[[Lentiginous nevus]].
===Images===
*[http://www.actasdermo.org/imatges/403/403v103n05/grande/403v103n05-90149637fig2.jpg ALN (actasdermo.org)].<ref name=pmid22421501/>


==Sign out==
==Sign out==
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- ATYPICAL LENTIGINOUS NEVUS OF THE ELDERY.
- ATYPICAL LENTIGINOUS NEVUS OF THE ELDERY.
-- COMPLETELY EXCISED, (CLEARANCE 2 MM).
-- COMPLETELY EXCISED, (CLEARANCE 2 MM).
</pre>
<pre>
SKIN LESION, CENTRAL BACK, SHAVE EXCISION:
- ATYPICAL LENTIGINOUS NEVUS.
-- COMPLETELY EXCISED, (CLEARANCE 2 MM).
-- MILD CYTOLOGIC ATYPIA.
</pre>
</pre>


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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
==External links==
*[http://www.dermpedia.org/dermpedia-textbook/compound-nevus-with-atypia Compound nevus with atypia (dermpedia.org)].


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Dermatopathology]]
[[Category:Dermatopathology]]

Latest revision as of 03:29, 11 September 2013

Atypical lentiginous nevus
Diagnosis in short
LM elongated rete ridges (key feature), diffuse (non-lamellar) superficial dermal fibrosis, mild-to-moderated cytologic atypia
LM DDx dysplastic nevus, melanoma in situ
Site skin
Associated Dx malignant melanoma
Clinical history elderly population
Clin. DDx melanoma

Atypical lentiginous nevus, also atypical lentiginous nevus of the elderly, is a melanocytic lesion associated with old age and melanoma. It may be abbreviated ALN.

It can be considered a type of dysplastic nevus.[1][2]

General

Gross

  • Pigmented lesion.
  • Size: 0.3-1.0 cm.[4]

Microscopic

Features:[4]

  • Elongated rete ridges - key feature.
  • Superficial dermal fibrosis, diffuse (non-lamellar) - important.
  • Mild-to-moderate cytologic atypia, focal.

Notes:[4]

  • Rarely dermal nests.
  • Mild-to-moderate inflammation.
  • Mitoses - never.
  • Solar elastosis - mild-to-moderate.

DDx:[4]

Images

Sign out

SKIN LESION, CENTRAL BACK, SHAVE EXCISION:
- ATYPICAL LENTIGINOUS NEVUS OF THE ELDERY.
-- COMPLETELY EXCISED, (CLEARANCE 2 MM).

SKIN LESION, CENTRAL BACK, SHAVE EXCISION:
- ATYPICAL LENTIGINOUS NEVUS.
-- COMPLETELY EXCISED, (CLEARANCE 2 MM).
-- MILD CYTOLOGIC ATYPIA.

Micro

The sections show hair-bearing skin with elongated rete ridges with focal bridging, and lentiginous, mildly atypical melanocytes. Non-lamellar superficial dermal fibrosis is present. No upward scatter of melanocytes is apparent.

The lesion is completely excised in the plane of section.

See also

References

  1. ↑ Edwards, SL.; Blessing, K. (Jun 2000). "Problematic pigmented lesions: approach to diagnosis.". J Clin Pathol 53 (6): 409-18. PMID 10911797.
  2. ↑ Kossard, S. (May 2002). "Atypical lentiginous junctional naevi of the elderly and melanoma.". Australas J Dermatol 43 (2): 93-101. PMID 11982564.
  3. ↑ Kossard, S.; Commens, C.; Symons, M.; Doyle, J. (1991). "Lentinginous dysplastic naevi in the elderly: a potential precursor for malignant melanoma.". Australas J Dermatol 32 (1): 27-37. PMID 1930003.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Agustí-Mejias, A.; Messeguer Badia, F.; García Ruiz, R.; Oliver Martínez, V.; Alegre de Miquel, V. (Jun 2012). "[Atypical lentiginous nevus: a clinical and histopathologic study of 14 cases].". Actas Dermosifiliogr 103 (5): 394-400. doi:10.1016/j.ad.2011.10.006. PMID 22421501.

External links

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