Endometrium with changes due to exogenous hormones: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Endometrium with hormone effect -- high mag.jpg | |||
| Width = | |||
| Caption = Endometrium with changes due to exogenous hormones. [[H&E stain]]. | |||
| Micro = inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses), decidualized stroma (nucleus central, eosinophilic cytoplasm, well-defined cell borders) | |||
| Subtypes = | |||
| LMDDx = [[endometrial hyperplasia with secretory changes]], [[secretory phase endometrium]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[endometrium]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = exogenous hormones ([[oral contraceptive pill]] or hormone releasing intrauterine device) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
{{ Infobox external links | |||
| Name = {{PAGENAME}} | |||
| EHVSC = 10170 | |||
| pathprotocols = | |||
| wikipedia = | |||
| pathoutlines = | |||
}} | |||
'''Endometrium with changes due to exogenous hormones''' is relatively common in [[endometrium|endometrial]] samples. | |||
'''Endometrial changes of oral contraception''', '''oral contraceptive effect''', '''OCP endometrium''', and '''endometrium with hormonal changes''' redirect here. | |||
The oral contraceptive pill is dealt with in the article ''[[oral contraceptive pill]]''. | |||
==General== | |||
*Very common. | |||
*Most pills are a mix of progesterone and estrogen. | |||
**The progesterone is what generates the characteristic appearance -- that is similar to [[pregnancy]]. | |||
*Same appearance is seen with a levonorgestrel-releasing intrauterine device, e.g. ''Mirena''. | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD1082>{{Ref PBoD|1082}}</ref> | |||
*Inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses). | |||
*Stroma decidualized -- mnemonic ''NEW'': | |||
**Nucleus central. | |||
**Eosinophilic cytoplasm. | |||
**Well-defined cell borders. | |||
DDx: | |||
*[[Endometrial hyperplasia with secretory changes]] - proliferative activity. | |||
*[[Secretory phase endometrium]] - glandular changes of the secretory phase (cytoplasmic vacuolization), secretions in the glands. | |||
===Image=== | |||
<gallery> | |||
Image:Endometrium_ocp_use1.jpg | Endometrium of woman on an OCP. (WC/Nephron) | |||
Image:Endometrium_ocp_use2.jpg | Endometrium of woman on an OCP. (WC/Nephron) | |||
Image:Endometrium_ocp_use3.jpg | Endometrium of woman on an OCP. (WC/Nephron) | |||
</gallery> | |||
<gallery> | |||
Image: Endometrium with hormone effect -- intermed mag.jpg | Hormone effect - intermed. mag. (WC) | |||
Image: Endometrium with hormone effect -- high mag.jpg | Hormone effect - high mag. (WC) | |||
Image: Endometrium with hormone effect -- very high mag.jpg | Hormone effect - very high mag. (WC) | |||
</gallery> | |||
==Sign out== | |||
<pre> | |||
Endometrium, Curettage: | |||
- Endometrium with nonproliferative endometrial glands and stromal decidualization, | |||
consistent with exogenous hormones. | |||
</pre> | |||
====Block letters==== | |||
<pre> | |||
ENDOMETRIUM, BIOPSY: | |||
- NON-PROLIFERATIVE ENDOMETRIAL GLANDS WITH STROMAL DECIDUALIZATION, CONSISTENT | |||
WITH EXOGENOUS HORMONES. | |||
</pre> | |||
===OCP effect and shedding endometrium=== | |||
<pre> | |||
ENDOMETRIUM, ASPIRATION: | |||
- ENDOMETRIUM WITH NONPROLIFERATIVE ENDOMETRIAL GLANDS AND | |||
STROMAL DECIDUALIZATION, COMPATIBLE WITH EXOGENOUS HORMONES. | |||
- EVIDENCE OF ENDOMETRIAL SHEDDING (BALLS OF CONDENSED STROMA | |||
ASSOCIATED NEUTROPHILS, AND BLOOD). | |||
- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
===Micro=== | |||
The sections show endometrium with nonproliferative endometrial glands and stromal | |||
decidualization. The gland-to-stroma ratio is within normal limits. | |||
==See also== | |||
*[[Endometrium]]. | |||
*[[Endometrial hyperplasia with secretory changes]]. | |||
*[[Decidualized endometrium]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | |||
[[Category:Endometrium]] | |||