Difference between revisions of "Pseudoepitheliomatous hyperplasia"

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'''Pseudoepitheliomatous hyperplasia''' is mimic of [[squamous cell carcinoma]].
'''Pseudoepitheliomatous hyperplasia''', abbreviated '''PEH''', is a benign reactive change of squamous mucosa that can mimic [[squamous cell carcinoma]].
 
==General==
*Benign.
*Not common.


It is seen in:
It is seen in:
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#[[Granular cell tumour]].
#[[Granular cell tumour]].
#Adjacent to an ulcer.
#Adjacent to an ulcer.
#*May form after an injury to the skin.<ref name=pmid17244318>{{Cite journal  | last1 = Fu | first1 = X. | last2 = Jiang | first2 = D. | last3 = Chen | first3 = W. | last4 = Sun Bs | first4 = T. | last5 = Sheng | first5 = Z. | title = Pseudoepitheliomatous hyperplasia formation after skin injury. | journal = Wound Repair Regen | volume = 15 | issue = 1 | pages = 39-46 | month =  | year =  | doi = 10.1111/j.1524-475X.2006.00183.x | PMID = 17244318 }}</ref>


==Microscopic==
==Microscopic==
Features:<ref>{{Cite journal  | last1 = Cui | first1 = W. | last2 = McGregor | first2 = DH. | last3 = Stark | first3 = SP. | last4 = Ulusarac | first4 = O. | last5 = Mathur | first5 = SC. | title = Pseudoepitheliomatous hyperplasia - an unusual reaction following tattoo: report of a case and review of the literature. | journal = Int J Dermatol | volume = 46 | issue = 7 | pages = 743-5 | month = Jul | year = 2007 | doi = 10.1111/j.1365-4632.2007.03150.x | PMID = 17614808 }}</ref>
Features:<ref name=pmid17614808>{{Cite journal  | last1 = Cui | first1 = W. | last2 = McGregor | first2 = DH. | last3 = Stark | first3 = SP. | last4 = Ulusarac | first4 = O. | last5 = Mathur | first5 = SC. | title = Pseudoepitheliomatous hyperplasia - an unusual reaction following tattoo: report of a case and review of the literature. | journal = Int J Dermatol | volume = 46 | issue = 7 | pages = 743-5 | month = Jul | year = 2007 | doi = 10.1111/j.1365-4632.2007.03150.x | PMID = 17614808 }}</ref>
*Epidermal thickening - irregular (acanthosis).<ref name=pmid21399447>{{Cite journal  | last1 = Zayour | first1 = M. | last2 = Lazova | first2 = R. | title = Pseudoepitheliomatous hyperplasia: a review. | journal = Am J Dermatopathol | volume = 33 | issue = 2 | pages = 112-22; quiz 123-6 | month = Apr | year = 2011 | doi = 10.1097/DAD.0b013e3181fcfb47 | PMID = 21399447 }}</ref>
*Acanthosis (epidermal thickening) - irregular .<ref name=pmid21399447>{{Cite journal  | last1 = Zayour | first1 = M. | last2 = Lazova | first2 = R. | title = Pseudoepitheliomatous hyperplasia: a review. | journal = Am J Dermatopathol | volume = 33 | issue = 2 | pages = 112-22; quiz 123-6 | month = Apr | year = 2011 | doi = 10.1097/DAD.0b013e3181fcfb47 | PMID = 21399447 }}</ref>
**Involves both follicles and and non-follicular epidermis.
**Involves both follicles and and non-follicular epidermis.
*Hyperkeratosis - thickening of the stratum corneum.
*Hyperkeratosis - thickening of the stratum corneum.
*Parakeratosis - nuclei in the stratum corneum.
*Parakeratosis - nuclei in the stratum corneum.


Images:
DDx:
*[[Squamous cell carcinoma]].
 
===Images===
*[http://www.pathologyoutlines.com/images/prostate/10_14.jpg Pseudoepitheliomatous hyperplasia (pathologyoutlines.com)].<ref>URL: [http://www.pathologyoutlines.com/topic/penscrotumpenssqhyper.html http://www.pathologyoutlines.com/topic/penscrotumpenssqhyper.html]. Accessed on: 10 November 2012.</ref>
*[http://www.pathologyoutlines.com/images/prostate/10_14.jpg Pseudoepitheliomatous hyperplasia (pathologyoutlines.com)].<ref>URL: [http://www.pathologyoutlines.com/topic/penscrotumpenssqhyper.html http://www.pathologyoutlines.com/topic/penscrotumpenssqhyper.html]. Accessed on: 10 November 2012.</ref>
*[http://www.the-dermatologist.com/sites/default/files/issues/January2012/Fungal%20Figure%204.png Pseudoepitheliomatous hyperplasia (the-dermatologist.com)].<ref>URL: [http://www.the-dermatologist.com/content/treating-rare-fungal-infections-coccidioidomycosis http://www.the-dermatologist.com/content/treating-rare-fungal-infections-coccidioidomycosis]. Accessed on: 10 November 2012.</ref>
*[http://www.the-dermatologist.com/sites/default/files/issues/January2012/Fungal%20Figure%204.png Pseudoepitheliomatous hyperplasia (the-dermatologist.com)].<ref>URL: [http://www.the-dermatologist.com/content/treating-rare-fungal-infections-coccidioidomycosis http://www.the-dermatologist.com/content/treating-rare-fungal-infections-coccidioidomycosis]. Accessed on: 10 November 2012.</ref>
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==References==
==References==
{{Reflist|1}}
{{Reflist|1}}


[[Category:Stuff]]
[[Category:Stuff]]
[[Category:Diagnosis]]

Latest revision as of 15:54, 24 June 2014

Pseudoepitheliomatous hyperplasia, abbreviated PEH, is a benign reactive change of squamous mucosa that can mimic squamous cell carcinoma.

General

  • Benign.
  • Not common.

It is seen in:

  1. Fungal infections.
  2. Inflammatory papillary hyperplasia.
  3. Granular cell tumour.
  4. Adjacent to an ulcer.
    • May form after an injury to the skin.[1]

Microscopic

Features:[2]

  • Acanthosis (epidermal thickening) - irregular .[3]
    • Involves both follicles and and non-follicular epidermis.
  • Hyperkeratosis - thickening of the stratum corneum.
  • Parakeratosis - nuclei in the stratum corneum.

DDx:

Images

References

  1. ↑ Fu, X.; Jiang, D.; Chen, W.; Sun Bs, T.; Sheng, Z.. "Pseudoepitheliomatous hyperplasia formation after skin injury.". Wound Repair Regen 15 (1): 39-46. doi:10.1111/j.1524-475X.2006.00183.x. PMID 17244318.
  2. ↑ Cui, W.; McGregor, DH.; Stark, SP.; Ulusarac, O.; Mathur, SC. (Jul 2007). "Pseudoepitheliomatous hyperplasia - an unusual reaction following tattoo: report of a case and review of the literature.". Int J Dermatol 46 (7): 743-5. doi:10.1111/j.1365-4632.2007.03150.x. PMID 17614808.
  3. ↑ Zayour, M.; Lazova, R. (Apr 2011). "Pseudoepitheliomatous hyperplasia: a review.". Am J Dermatopathol 33 (2): 112-22; quiz 123-6. doi:10.1097/DAD.0b013e3181fcfb47. PMID 21399447.
  4. ↑ URL: http://www.pathologyoutlines.com/topic/penscrotumpenssqhyper.html. Accessed on: 10 November 2012.
  5. ↑ URL: http://www.the-dermatologist.com/content/treating-rare-fungal-infections-coccidioidomycosis. Accessed on: 10 November 2012.
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