Difference between revisions of "Behçet's syndrome"

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==General==
==General==
Etiology:
Etiology:
*Unknown - hypothesized to be infectious due to the epidemiology.<ref name=pmid22100288/>
*Unknown - hypothesized to be infectious (due to the epidemiology<ref name=pmid22100288/>) on a background of genetic susceptibility.<ref name=pmid17207160/>  


===Clinical===
===Clinical===
Line 13: Line 13:


==Microscopic==
==Microscopic==
Features - vasculitis:<ref name=pmid22100288/>
Features - small vessel [[vasculitis]]:<ref name=pmid22100288/><ref name=pmid17207160>{{Cite journal  | last1 = Kalayciyan | first1 = A. | last2 = Zouboulis | first2 = C. | title = An update on Behçet's disease. | journal = J Eur Acad Dermatol Venereol | volume = 21 | issue = 1 | pages = 1-10 | month = Jan | year = 2007 | doi = 10.1111/j.1468-3083.2006.01863.x | PMID = 17207160 }}</ref>
*[[Fibrinoid necrosis]] of the vessel walls.
*[[Fibrinoid necrosis]] of the vessel walls.
*Inflammatory cells in the blood vessel walls.
*Inflammatory cells in the blood vessel walls.
==See also==
*[[Vasculitides]].


==References==
==References==

Latest revision as of 23:12, 1 June 2012

Behçet's syndrome, also Behçet's disease, is a rare disorder classically described as the triad of:[1]

  1. Oral aphthous ulcers.
  2. Genital ulcers.
  3. Uveitis

General

Etiology:

  • Unknown - hypothesized to be infectious (due to the epidemiology[2]) on a background of genetic susceptibility.[3]

Clinical

  • Pathergy[2] = minor trauma (to the skin) results in a non-healing lesion.

Microscopic

Features - small vessel vasculitis:[2][3]

See also

References

  1. Online 'Mendelian Inheritance in Man' (OMIM) 109650
  2. 2.0 2.1 2.2 Hatemi, G.; Yazici, H. (Jun 2011). "Behçet's syndrome and micro-organisms.". Best Pract Res Clin Rheumatol 25 (3): 389-406. doi:10.1016/j.berh.2011.05.002. PMID 22100288.
  3. 3.0 3.1 Kalayciyan, A.; Zouboulis, C. (Jan 2007). "An update on Behçet's disease.". J Eur Acad Dermatol Venereol 21 (1): 1-10. doi:10.1111/j.1468-3083.2006.01863.x. PMID 17207160.